tetano
Editor, Senior Moderator
Cardiovasc Diabetol. 2020 May 11;19(1):58. doi: 10.1186/s12933-020-01035-2.
Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19.
Ren H[SUP]1[/SUP], Yang Y[SUP]1[/SUP], Wang F[SUP]1[/SUP], Yan Y[SUP]1[/SUP], Shi X[SUP]1[/SUP], Dong K[SUP]1[/SUP], Yu X[SUP]1[/SUP], Zhang S[SUP]2[/SUP].
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Abstract
BACKGROUND:
The triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. This study aims to evaluate the association of the TyG index with the severity and mortality of coronavirus disease 2019 (COVID-19).
METHODS:
The study included a cohort of 151 patients with COVID-19 admitted in a tertiary teaching hospital in Wuhan. Regression models were used to investigate the association between TyG with severity and mortality of COVID-19.
RESULTS:
In this cohort, 39 (25.8%) patients had diabetes, 62 (41.1%) patients were severe cases, while 33 (22.0%) patients died in hospital. The TyG index levels were significantly higher in the severe cases and death group (mild vs. severe 8.7 ? 0.6 vs. 9.2 ? 0.6, P < 0.001; survivor vs. deceased 8.8 ? 0.6 vs. 9.3 ? 0.7, P < 0.001), respectively. The TyG index was significantly associated with an increased risk of severe case and mortality, after controlling for potential confounders (OR for severe case, 2.9, 95% CI 1.2-6.3, P = 0.007; OR for mortality, 2.9, 95% CI 1.2-6.7, P = 0.016). The associations were not statistically significant for further adjustment of inflammatory factors.
CONCLUSION:
TyG index was closely associated with the severity and morbidity in COVID-19 patients, thus it may be a valuable marker for identifying poor outcome of COVID-19.
KEYWORDS:
COVID-19; Mortality; Severity; TyG index
PMID:32393351DOI:10.1186/s12933-020-01035-2
Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19.
Ren H[SUP]1[/SUP], Yang Y[SUP]1[/SUP], Wang F[SUP]1[/SUP], Yan Y[SUP]1[/SUP], Shi X[SUP]1[/SUP], Dong K[SUP]1[/SUP], Yu X[SUP]1[/SUP], Zhang S[SUP]2[/SUP].
Author information
Abstract
BACKGROUND:
The triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. This study aims to evaluate the association of the TyG index with the severity and mortality of coronavirus disease 2019 (COVID-19).
METHODS:
The study included a cohort of 151 patients with COVID-19 admitted in a tertiary teaching hospital in Wuhan. Regression models were used to investigate the association between TyG with severity and mortality of COVID-19.
RESULTS:
In this cohort, 39 (25.8%) patients had diabetes, 62 (41.1%) patients were severe cases, while 33 (22.0%) patients died in hospital. The TyG index levels were significantly higher in the severe cases and death group (mild vs. severe 8.7 ? 0.6 vs. 9.2 ? 0.6, P < 0.001; survivor vs. deceased 8.8 ? 0.6 vs. 9.3 ? 0.7, P < 0.001), respectively. The TyG index was significantly associated with an increased risk of severe case and mortality, after controlling for potential confounders (OR for severe case, 2.9, 95% CI 1.2-6.3, P = 0.007; OR for mortality, 2.9, 95% CI 1.2-6.7, P = 0.016). The associations were not statistically significant for further adjustment of inflammatory factors.
CONCLUSION:
TyG index was closely associated with the severity and morbidity in COVID-19 patients, thus it may be a valuable marker for identifying poor outcome of COVID-19.
KEYWORDS:
COVID-19; Mortality; Severity; TyG index
PMID:32393351DOI:10.1186/s12933-020-01035-2