tetano
Editor, Senior Moderator
Cardiol J
. 2023 Jan 2.
doi: 10.5603/CJ.a2022.0123. Online ahead of print.
COVID-19-induced coagulopathy: Experience, achievements, prospects
Leonid Dubey[SUP] 1 [/SUP], Olga Dorosh[SUP] 1 2 [/SUP], Nataliya Dubey[SUP] 1 [/SUP], Svitlana Doan[SUP] 3 4 [/SUP], Olena Kozishkurt[SUP] 4 [/SUP], Oleksandr Duzenko[SUP] 4 [/SUP], Olena Kozlova[SUP] 1 2 [/SUP], Veronika Ievtukh[SUP] 1 [/SUP], Jerzy R Ladny[SUP] 5 6 [/SUP], Michal Pruc[SUP] 6 [/SUP], Lukasz Szarpak[SUP] 7 [/SUP], Julia Pukach[SUP] 1 [/SUP]
Affiliations
Abstract
The presence of coagulopathy as part of the systemic inflammatory response syndrome is a characteristic feature of severe coronavirus disease 2019 (COVID-19). Hematological changes (increased DD-dimer, prolonged activated partial thromboplastin clotting time [APTT] and prothrombin time [PT], high fibrinogen levels) have been observed in hospitalized patients with COVID-19, which characterize the risk of thrombotic events. Against the background of COVID-19 there is endothelial dysfunction, hypoxia and pulmonary congestion, mediated by thrombosis and microvascular occlusion. Up to 71.4% of patients who died from COVID-19 had disseminated intravascular coagulation syndrome, compared with only 0.6% of survivors. The main manifestation of COVID-19-associated coagulopathy is a significant increase in DD without a decrease in platelet count or prolongation of APTT and PT, indicating increased thrombin formation and the development of local fibrinolysis. An increase in DD levels of more than 3-4 times was associated with higher in-hospital mortality. Therefore, COVID-19 requires assessment of the severity of the disease for further tactics of thromboprophylaxis. The need for continued thromboprophylaxis, or therapeutic anticoagulation, in patients after inpatient treatment for two weeks using imaging techniques to assess of thrombosis assessment.
Keywords: COVID-19-induced coagulopathy; SARS-CoV-2; coronavirus disease 2019 (COVID-19) infection.
. 2023 Jan 2.
doi: 10.5603/CJ.a2022.0123. Online ahead of print.
COVID-19-induced coagulopathy: Experience, achievements, prospects
Leonid Dubey[SUP] 1 [/SUP], Olga Dorosh[SUP] 1 2 [/SUP], Nataliya Dubey[SUP] 1 [/SUP], Svitlana Doan[SUP] 3 4 [/SUP], Olena Kozishkurt[SUP] 4 [/SUP], Oleksandr Duzenko[SUP] 4 [/SUP], Olena Kozlova[SUP] 1 2 [/SUP], Veronika Ievtukh[SUP] 1 [/SUP], Jerzy R Ladny[SUP] 5 6 [/SUP], Michal Pruc[SUP] 6 [/SUP], Lukasz Szarpak[SUP] 7 [/SUP], Julia Pukach[SUP] 1 [/SUP]
Affiliations
- PMID: 36588310
- DOI: 10.5603/CJ.a2022.0123
Abstract
The presence of coagulopathy as part of the systemic inflammatory response syndrome is a characteristic feature of severe coronavirus disease 2019 (COVID-19). Hematological changes (increased DD-dimer, prolonged activated partial thromboplastin clotting time [APTT] and prothrombin time [PT], high fibrinogen levels) have been observed in hospitalized patients with COVID-19, which characterize the risk of thrombotic events. Against the background of COVID-19 there is endothelial dysfunction, hypoxia and pulmonary congestion, mediated by thrombosis and microvascular occlusion. Up to 71.4% of patients who died from COVID-19 had disseminated intravascular coagulation syndrome, compared with only 0.6% of survivors. The main manifestation of COVID-19-associated coagulopathy is a significant increase in DD without a decrease in platelet count or prolongation of APTT and PT, indicating increased thrombin formation and the development of local fibrinolysis. An increase in DD levels of more than 3-4 times was associated with higher in-hospital mortality. Therefore, COVID-19 requires assessment of the severity of the disease for further tactics of thromboprophylaxis. The need for continued thromboprophylaxis, or therapeutic anticoagulation, in patients after inpatient treatment for two weeks using imaging techniques to assess of thrombosis assessment.
Keywords: COVID-19-induced coagulopathy; SARS-CoV-2; coronavirus disease 2019 (COVID-19) infection.