tetano
Editor, Senior Moderator
Cardiol Discov
. 2022 Jan 6;2(2):77-82.
doi: 10.1097/CD9.0000000000000044. eCollection 2022 Jun.
Non-Ischemic, Non-Hypoxic Myocardial Injury, and Long-Term Mortality in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
Fajiu Li[SUP] 1 [/SUP], Xijie Zhu[SUP] 2 [/SUP], Ziyang Zhu[SUP] 1 [/SUP], Yinjian Yang[SUP] 3 [/SUP], Zhuang Tian[SUP] 2 [/SUP], Duolao Wang[SUP] 4 [/SUP], Shi Chen[SUP] 1 [/SUP], Xiaoyan Gao[SUP] 1 [/SUP], Yalin Xu[SUP] 5 [/SUP], Bo Zhang[SUP] 6 [/SUP], Wei Yu[SUP] 1 [/SUP], Min Liu[SUP] 5 [/SUP], Xiqi Xu[SUP] 2 [/SUP], Chenghong Li[SUP] 1 [/SUP], Shuyang Zhang[SUP] 2 [/SUP]
Affiliations
Abstract
Objective: Cardiac damage is commonly reported in patients with coronavirus disease 2019 (COVID-19) but its prevalence and impact on the long-term survival of patients remain uncertain. This study aimed to explore the prevalence of myocardial injury and assess its prognostic value in patients with COVID-19.
Methods: A single-center, retrospective cohort study was performed at the Affiliated Hospital of Jianghan University. Data from 766 patients with confirmed COVID-19 who were hospitalized from December 27, 2019 to April 25, 2020 were collected. Demographic, clinical, laboratory, electrocardiogram, treatment data and all-cause mortality during follow-up were collected and analyzed.
Results: Of the 766 patients with moderate to critically ill COVID-19, 86 (11.2%) died after a mean follow-up of 72.8 days. Myocardial injury occurred in 94 (12.3%) patients. The mortality rate was 64.9% (61/94) and 3.7% (25/672) in patients with and without myocardial injury, respectively. Cox regression showed that myocardial injury was an independent risk factor for mortality (hazard ratio: 8.76, 95% confidence interval: 4.76-16.11, P < 0.001). Of the 90 patients with myocardial injury with electrocardiogram results, sinus tachycardia was present in 29, bundle branch block in 26, low voltage in 10, and abnormal T-wave in 53.
Conclusions: COVID-19 not only involves pneumonia but also cardiac damage. Myocardial injury is a common complication and an independent risk factor for mortality in COVID-19 patients.
Keywords: COVID-19; Coronavirus; Mortality; Myocardial injury.
. 2022 Jan 6;2(2):77-82.
doi: 10.1097/CD9.0000000000000044. eCollection 2022 Jun.
Non-Ischemic, Non-Hypoxic Myocardial Injury, and Long-Term Mortality in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
Fajiu Li[SUP] 1 [/SUP], Xijie Zhu[SUP] 2 [/SUP], Ziyang Zhu[SUP] 1 [/SUP], Yinjian Yang[SUP] 3 [/SUP], Zhuang Tian[SUP] 2 [/SUP], Duolao Wang[SUP] 4 [/SUP], Shi Chen[SUP] 1 [/SUP], Xiaoyan Gao[SUP] 1 [/SUP], Yalin Xu[SUP] 5 [/SUP], Bo Zhang[SUP] 6 [/SUP], Wei Yu[SUP] 1 [/SUP], Min Liu[SUP] 5 [/SUP], Xiqi Xu[SUP] 2 [/SUP], Chenghong Li[SUP] 1 [/SUP], Shuyang Zhang[SUP] 2 [/SUP]
Affiliations
- PMID: 36540721
- PMCID: PMC9749942
- DOI: 10.1097/CD9.0000000000000044
Abstract
Objective: Cardiac damage is commonly reported in patients with coronavirus disease 2019 (COVID-19) but its prevalence and impact on the long-term survival of patients remain uncertain. This study aimed to explore the prevalence of myocardial injury and assess its prognostic value in patients with COVID-19.
Methods: A single-center, retrospective cohort study was performed at the Affiliated Hospital of Jianghan University. Data from 766 patients with confirmed COVID-19 who were hospitalized from December 27, 2019 to April 25, 2020 were collected. Demographic, clinical, laboratory, electrocardiogram, treatment data and all-cause mortality during follow-up were collected and analyzed.
Results: Of the 766 patients with moderate to critically ill COVID-19, 86 (11.2%) died after a mean follow-up of 72.8 days. Myocardial injury occurred in 94 (12.3%) patients. The mortality rate was 64.9% (61/94) and 3.7% (25/672) in patients with and without myocardial injury, respectively. Cox regression showed that myocardial injury was an independent risk factor for mortality (hazard ratio: 8.76, 95% confidence interval: 4.76-16.11, P < 0.001). Of the 90 patients with myocardial injury with electrocardiogram results, sinus tachycardia was present in 29, bundle branch block in 26, low voltage in 10, and abnormal T-wave in 53.
Conclusions: COVID-19 not only involves pneumonia but also cardiac damage. Myocardial injury is a common complication and an independent risk factor for mortality in COVID-19 patients.
Keywords: COVID-19; Coronavirus; Mortality; Myocardial injury.