tetano
Editor, Senior Moderator
Card Electrophysiol Clin
. 2022 Mar;14(1):21-28.
doi: 10.1016/j.ccep.2021.10.003. Epub 2021 Oct 30.
COVID-19-Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations
Maria Paola Canale[SUP] 1 [/SUP], Rossella Menghini[SUP] 2 [/SUP], Eugenio Martelli[SUP] 3 [/SUP], Massimo Federici[SUP] 4 [/SUP]
Affiliations
Abstract
Coronavirus-19 disease (COVID-19) affects more people than previous coronavirus infections and has a higher mortality. Higher incidence and mortality can probably be explained by COVID-19 causative agent's greater affinity (about 10-20 times) for angiotensin-converting enzyme 2 (ACE2) receptor compared with other coronaviruses. Here, the authors first summarize clinical manifestations, then present symptoms of COVID-19 and the pathophysiological mechanisms underlying specific organ/system disease. The worse clinical outcome observed in COVID-19 patients with diabetes may be in part related to the increased ADAM17 activity and its unbalanced interplay with ACE2. Therefore, strategies aimed to inhibit ADAM17 activity may be explored to develop new effective therapeutic approaches.
Keywords: ACE2; ADAM17; Covid-19 clinical manifestations; Endothelial dysfunction; Systemic inflammation.
. 2022 Mar;14(1):21-28.
doi: 10.1016/j.ccep.2021.10.003. Epub 2021 Oct 30.
COVID-19-Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations
Maria Paola Canale[SUP] 1 [/SUP], Rossella Menghini[SUP] 2 [/SUP], Eugenio Martelli[SUP] 3 [/SUP], Massimo Federici[SUP] 4 [/SUP]
Affiliations
- PMID: 35221082
- DOI: 10.1016/j.ccep.2021.10.003
Abstract
Coronavirus-19 disease (COVID-19) affects more people than previous coronavirus infections and has a higher mortality. Higher incidence and mortality can probably be explained by COVID-19 causative agent's greater affinity (about 10-20 times) for angiotensin-converting enzyme 2 (ACE2) receptor compared with other coronaviruses. Here, the authors first summarize clinical manifestations, then present symptoms of COVID-19 and the pathophysiological mechanisms underlying specific organ/system disease. The worse clinical outcome observed in COVID-19 patients with diabetes may be in part related to the increased ADAM17 activity and its unbalanced interplay with ACE2. Therefore, strategies aimed to inhibit ADAM17 activity may be explored to develop new effective therapeutic approaches.
Keywords: ACE2; ADAM17; Covid-19 clinical manifestations; Endothelial dysfunction; Systemic inflammation.