tetano
Editor, Senior Moderator
Cancers (Basel)
. 2020 Nov 5;12(11):E3266.
doi: 10.3390/cancers12113266.
SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis
Gaurav Seth[SUP] 1 [/SUP], Saira Sethi[SUP] 2 [/SUP], Shristi Bhattarai[SUP] 1 [/SUP], Geetanjali Saini[SUP] 1 [/SUP], Chandra Bhushan Singh[SUP] 3 [/SUP], Ritu Aneja[SUP] 1 [/SUP]
Affiliations
Abstract
The severity of coronavirus disease 2019 (COVID-19) symptoms and outcomes vary immensely among patients. Predicting disease progression and managing disease symptoms is even more challenging in cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Cancer therapies, including chemotherapy, radiotherapy, and immunotherapy, often suppress the immune system, rendering cancer patients more susceptible to SARS-CoV-2 infection and the development of severe complications. However, data on the effects of immunosuppression on COVID-19 outcomes in cancer patients remain limited. Further investigations are warranted to better understand the implications of SARS-CoV-2 infection in cancer patients, particularly those that are immunocompromised. In this review, we outline the current knowledge of the effects of SARS-CoV-2 infection in cancer patients.
Keywords: COVID-19; SARS-CoV-2; cancer prognosis; immunosuppression.
. 2020 Nov 5;12(11):E3266.
doi: 10.3390/cancers12113266.
SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis
Gaurav Seth[SUP] 1 [/SUP], Saira Sethi[SUP] 2 [/SUP], Shristi Bhattarai[SUP] 1 [/SUP], Geetanjali Saini[SUP] 1 [/SUP], Chandra Bhushan Singh[SUP] 3 [/SUP], Ritu Aneja[SUP] 1 [/SUP]
Affiliations
- PMID: 33167313
- DOI: 10.3390/cancers12113266
Abstract
The severity of coronavirus disease 2019 (COVID-19) symptoms and outcomes vary immensely among patients. Predicting disease progression and managing disease symptoms is even more challenging in cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Cancer therapies, including chemotherapy, radiotherapy, and immunotherapy, often suppress the immune system, rendering cancer patients more susceptible to SARS-CoV-2 infection and the development of severe complications. However, data on the effects of immunosuppression on COVID-19 outcomes in cancer patients remain limited. Further investigations are warranted to better understand the implications of SARS-CoV-2 infection in cancer patients, particularly those that are immunocompromised. In this review, we outline the current knowledge of the effects of SARS-CoV-2 infection in cancer patients.
Keywords: COVID-19; SARS-CoV-2; cancer prognosis; immunosuppression.