tetano
Editor, Senior Moderator
Cancers (Basel)
. 2022 Apr 27;14(9):2191.
doi: 10.3390/cancers14092191.
Outcome and Prognostic Factors of COVID-19 Infection in Swiss Cancer Patients: Final Results of SAKK 80/20 (CaSA)
Markus Joerger[SUP] 1 [/SUP], Yannis Metaxas[SUP] 2 [/SUP], Khalil Zaman[SUP] 3 [/SUP], Olivier Michielin[SUP] 4 [/SUP], Nicolas Mach[SUP] 5 [/SUP], Adrienne Bettini[SUP] 6 [/SUP], Andreas M Schmitt[SUP] 7 [/SUP], Nathan Cantoni[SUP] 8 [/SUP], Clemens B Caspar[SUP] 9 [/SUP], Sonja Stettler[SUP] 10 [/SUP], Roma Malval[SUP] 11 [/SUP], Miklos Pless[SUP] 12 [/SUP], Christian Britschgi[SUP] 13 [/SUP], Christoph Renner[SUP] 14 [/SUP], Dieter Koeberle[SUP] 15 [/SUP], Jessica D Schulz[SUP] 16 [/SUP], Christoph Kopp[SUP] 16 [/SUP], Stefanie Hayoz[SUP] 16 [/SUP], Anastasios Stathis[SUP] 17 [/SUP], Roger von Moos[SUP] 18 [/SUP], Swiss Group for Clinical Cancer Research (SAKK)
Affiliations
Abstract
Purpose: These are the final results of a national registry on cancer patients with COVID-19 in Switzerland.
Methods: We collected data on symptomatic COVID-19-infected cancer patients from 23 Swiss sites over a one-year period starting on 1 March 2020. The main objective was to assess the outcome (i.e., mortality, rate of hospitalization, ICU admission) of COVID-19 infection in cancer patients; the main secondary objective was to define prognostic factors.
Results: From 455 patients included, 205 patients (45%) had non-curative disease, 241 patients (53%) were hospitalized for COVID-19, 213 (47%) required oxygen, 43 (9%) invasive ventilation and 62 (14%) were admitted to the ICU. Death from COVID-19 infection occurred in 98 patients, resulting in a mortality rate of 21.5%. Age ≥65 years versus <65 years (OR 3.14, p = 0.003), non-curative versus curative disease (OR 2.42, p = 0.012), ICU admission (OR 4.45, p < 0.001) and oxygen requirement (OR 20.28, p < 0.001) were independently associated with increased mortality.
Conclusions: We confirmed high COVID-19 severity and mortality in real-world cancer patients during the first and second wave of the pandemic in a country with a decentralized, high-quality, universal-access health care system. COVID-19-associated mortality was particularly high for those of older age in a non-curative disease setting, requiring oxygen or ICU care.
Keywords: COVID-19; cancer; cancer treatment; coronavirus; pandemic.
. 2022 Apr 27;14(9):2191.
doi: 10.3390/cancers14092191.
Outcome and Prognostic Factors of COVID-19 Infection in Swiss Cancer Patients: Final Results of SAKK 80/20 (CaSA)
Markus Joerger[SUP] 1 [/SUP], Yannis Metaxas[SUP] 2 [/SUP], Khalil Zaman[SUP] 3 [/SUP], Olivier Michielin[SUP] 4 [/SUP], Nicolas Mach[SUP] 5 [/SUP], Adrienne Bettini[SUP] 6 [/SUP], Andreas M Schmitt[SUP] 7 [/SUP], Nathan Cantoni[SUP] 8 [/SUP], Clemens B Caspar[SUP] 9 [/SUP], Sonja Stettler[SUP] 10 [/SUP], Roma Malval[SUP] 11 [/SUP], Miklos Pless[SUP] 12 [/SUP], Christian Britschgi[SUP] 13 [/SUP], Christoph Renner[SUP] 14 [/SUP], Dieter Koeberle[SUP] 15 [/SUP], Jessica D Schulz[SUP] 16 [/SUP], Christoph Kopp[SUP] 16 [/SUP], Stefanie Hayoz[SUP] 16 [/SUP], Anastasios Stathis[SUP] 17 [/SUP], Roger von Moos[SUP] 18 [/SUP], Swiss Group for Clinical Cancer Research (SAKK)
Affiliations
- PMID: 35565320
- DOI: 10.3390/cancers14092191
Abstract
Purpose: These are the final results of a national registry on cancer patients with COVID-19 in Switzerland.
Methods: We collected data on symptomatic COVID-19-infected cancer patients from 23 Swiss sites over a one-year period starting on 1 March 2020. The main objective was to assess the outcome (i.e., mortality, rate of hospitalization, ICU admission) of COVID-19 infection in cancer patients; the main secondary objective was to define prognostic factors.
Results: From 455 patients included, 205 patients (45%) had non-curative disease, 241 patients (53%) were hospitalized for COVID-19, 213 (47%) required oxygen, 43 (9%) invasive ventilation and 62 (14%) were admitted to the ICU. Death from COVID-19 infection occurred in 98 patients, resulting in a mortality rate of 21.5%. Age ≥65 years versus <65 years (OR 3.14, p = 0.003), non-curative versus curative disease (OR 2.42, p = 0.012), ICU admission (OR 4.45, p < 0.001) and oxygen requirement (OR 20.28, p < 0.001) were independently associated with increased mortality.
Conclusions: We confirmed high COVID-19 severity and mortality in real-world cancer patients during the first and second wave of the pandemic in a country with a decentralized, high-quality, universal-access health care system. COVID-19-associated mortality was particularly high for those of older age in a non-curative disease setting, requiring oxygen or ICU care.
Keywords: COVID-19; cancer; cancer treatment; coronavirus; pandemic.