sharon sanders
Editor-in-Chief & President
Available online 15 September 2020
In Press, Journal Pre-proofWhat are Journal Pre-proof articles?
Article
SARS-CoV-2 Viral Load Predicts Mortality in Patients with and Without Cancer Who Are Hospitalized with COVID-19
Author links open overlay panelLars F.Westblade[SUP]1[/SUP][SUP]2[/SUP][SUP]3[/SUP][SUP]#[/SUP]GagandeepBrar[SUP]1[/SUP][SUP]3[/SUP][SUP]#[/SUP]Laura C.Pinheiro[SUP]1[/SUP]DemetriosPaidoussis[SUP]4[/SUP]MangalaRajan[SUP]1[/SUP]PeterMartin[SUP]1[/SUP][SUP]3[/SUP]ParagGoyal[SUP]1[/SUP][SUP]3[/SUP]Jorge L.Sepulveda[SUP]5[/SUP]LisaZhang[SUP]1[/SUP]GaryGeorge[SUP]1[/SUP]DakaiLiu[SUP]4[/SUP]SusanWhittier[SUP]6[/SUP][SUP]7[/SUP]MarkusPlate[SUP]1[/SUP][SUP]3[/SUP]Catherine B.Small[SUP]1[/SUP][SUP]3[/SUP]Jacob H.Rand[SUP]2[/SUP][SUP]3[/SUP]Melissa M.Cushing[SUP]2[/SUP][SUP]3[/SUP]Thomas J.Walsh[SUP]1[/SUP][SUP]3[/SUP]JosephCooke[SUP]1[/SUP][SUP]4[/SUP]…Michael J.Satlin[SUP]1[/SUP][SUP]3[/SUP]
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https://doi.org/10.1016/j.ccell.2020.09.007Get rights and content
HIGHLIGHTS
•High admission viral load predicts mortality in hospitalized patients with and without cancer
•Patients with hematologic malignancies have higher viral loads than patients without cancer
•Viral load results may assist clinicians in caring for hospitalized patients with COVID-19
Summary
Patients with cancer may be at increased risk of severe coronavirus disease 2019 (COVID-19), but the role of viral load on this risk is unknown. We measured SARS-CoV-2 viral load using cycle threshold (C[SUB]T[/SUB]) values from reverse transcription-polymerase chain reaction assays applied to nasopharyngeal swab specimens in 100 patients with cancer and 2914 without cancer who were admitted to three New York City hospitals. Overall, the in-hospital mortality rate was 38.8% among patients with a high viral load, 24.1% among patients with a medium viral load, and 15.3% among patients with a low viral load (P<0.001). Similar findings were observed in patients with cancer (high, 45.2% mortality; medium, 28.0%; low, 12.1%; P=0.008). Patients with hematologic malignancies had higher median viral loads (C[SUB]T[/SUB]=25.0) than patients without cancer (C[SUB]T[/SUB]=29.2; P=0.0039). SARS-CoV-2 viral load results may offer vital prognostic information for patients with and without cancer who are hospitalized with COVID-19.
https://www.sciencedirect.com/scienc...35610820304815
In Press, Journal Pre-proofWhat are Journal Pre-proof articles?
Article
SARS-CoV-2 Viral Load Predicts Mortality in Patients with and Without Cancer Who Are Hospitalized with COVID-19
Author links open overlay panelLars F.Westblade[SUP]1[/SUP][SUP]2[/SUP][SUP]3[/SUP][SUP]#[/SUP]GagandeepBrar[SUP]1[/SUP][SUP]3[/SUP][SUP]#[/SUP]Laura C.Pinheiro[SUP]1[/SUP]DemetriosPaidoussis[SUP]4[/SUP]MangalaRajan[SUP]1[/SUP]PeterMartin[SUP]1[/SUP][SUP]3[/SUP]ParagGoyal[SUP]1[/SUP][SUP]3[/SUP]Jorge L.Sepulveda[SUP]5[/SUP]LisaZhang[SUP]1[/SUP]GaryGeorge[SUP]1[/SUP]DakaiLiu[SUP]4[/SUP]SusanWhittier[SUP]6[/SUP][SUP]7[/SUP]MarkusPlate[SUP]1[/SUP][SUP]3[/SUP]Catherine B.Small[SUP]1[/SUP][SUP]3[/SUP]Jacob H.Rand[SUP]2[/SUP][SUP]3[/SUP]Melissa M.Cushing[SUP]2[/SUP][SUP]3[/SUP]Thomas J.Walsh[SUP]1[/SUP][SUP]3[/SUP]JosephCooke[SUP]1[/SUP][SUP]4[/SUP]…Michael J.Satlin[SUP]1[/SUP][SUP]3[/SUP]
Show more
https://doi.org/10.1016/j.ccell.2020.09.007Get rights and content
HIGHLIGHTS
•High admission viral load predicts mortality in hospitalized patients with and without cancer
•Patients with hematologic malignancies have higher viral loads than patients without cancer
•Viral load results may assist clinicians in caring for hospitalized patients with COVID-19
Summary
Patients with cancer may be at increased risk of severe coronavirus disease 2019 (COVID-19), but the role of viral load on this risk is unknown. We measured SARS-CoV-2 viral load using cycle threshold (C[SUB]T[/SUB]) values from reverse transcription-polymerase chain reaction assays applied to nasopharyngeal swab specimens in 100 patients with cancer and 2914 without cancer who were admitted to three New York City hospitals. Overall, the in-hospital mortality rate was 38.8% among patients with a high viral load, 24.1% among patients with a medium viral load, and 15.3% among patients with a low viral load (P<0.001). Similar findings were observed in patients with cancer (high, 45.2% mortality; medium, 28.0%; low, 12.1%; P=0.008). Patients with hematologic malignancies had higher median viral loads (C[SUB]T[/SUB]=25.0) than patients without cancer (C[SUB]T[/SUB]=29.2; P=0.0039). SARS-CoV-2 viral load results may offer vital prognostic information for patients with and without cancer who are hospitalized with COVID-19.
https://www.sciencedirect.com/scienc...35610820304815