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Canada not planning H7N9 bird flu vaccine studies; will watch US results: PHAC

Pathfinder

Editor, Senior Moderator
The Canadian PressMay 9, 2013 19:46

Canada not planning H7N9 bird flu vaccine studies; will watch US results: PHAC

TORONTO - Canada currently has no plans to ask its pandemic flu vaccine manufacturers to make trial batches of vaccine to protect against the new H7N9 bird flu, senior officials of the Public Health Agency of Canada have revealed.

While the U.S. government has said it will ask several of flu vaccine manufacturers to start growing up batches of serum against the new virus this summer, Canada will watch, wait and learn from the work the U.S. does, the officials said in an interview with The Canadian Press.

"What we need to do in the international research-scientific community, the public health community is to complement each other. If the U.S. is doing something, we don't need to do it necessarily," explained Dr. Frank Plummer, head of the National Microbiology Laboratory in Winnipeg.

Dr. John Spika, director general of the public health agency's center for immunization and respiratory infectious diseases, said doing this early work is more crucial for the United States, which will have to make a decision about whether to use an adjuvant with H7N9 vaccine, if the virus causes a pandemic. An adjuvant is a product that boosts the immune response to a vaccine, typically allowing a smaller dose to have a protective effect.

The U.S. has not used adjuvants with flu vaccine before, but Canada used adjuvanted vaccine during the 2009 pandemic. And when the federal government signed new pandemic vaccine contracts in 2011, it stipulated it wants adjuvanted vaccine the next time it needs pandemic vaccine.

"So this step of doing some early clinical trials looking at immunogenicity is really going to be critical for the U.S. go-forward process. Whereas here in Canada, we've already made a decision on what kind of vaccine we're going to use. It's going to be an adjuvanted one," Spika said.

Read more...
http://www.globalpost.com/dispatch/...ning-h7n9-bird-flu-vaccine-studies-will-watch
 
Re: Canada not planning H7N9 bird flu vaccine studies; will watch US results: PHAC

Extract:

Machine translation


Officer of Medicago said Wednesday it was ready to undertake in-depth studies on the potential of a vaccine against influenza A (H7N9).

It must be said that the H7N9 flu virus is highly virulent in these days in Asia. For now, the avian flu virus is the cause of 31 deaths confirmed in Chinese soil and more than 130 cases reported to the World Health Organization.

The vaccine candidate Medicago is produced from a technology based on virus-like particles. The vaccine, being purified, will soon be tested on animals.

Fourteen days were enough

Through a unique process designed to Quebec from tobacco leaves, Medicago took only 14 days to develop a candidate vaccine against the H7N9 virus. To do so, the biopharmaceutical needed only the genetic sequence of the virus strain.

The CEO of Medicago, Andy Sheldon, argues that the biopharmaceutical company is the first "to his knowledge" to produce a candidate vaccine against the H7N9 flu virus. "This positions us as a major player in the fight against the pandemic," he said Wednesday at the Sun .

http://www.lapresse.ca/le-soleil/af...at-antigrippe-fait-bondir-le-titre-de-15-.php
 
Re: Canada not planning H7N9 bird flu vaccine studies; will watch US results: PHAC

there will presumably be also secret experiments, experiments whose results
are not published or mustn't be published because of dual-use concerns.

It would be interesting to know whether and how much these secret results
are being distributed,coordinated,discussed internationally, by WHO.

What countries are involved in what DUOC information exchange networks,
i.e. whether China,North Korea,Iran are involved.

------edit-----
ahh, sorry, the headline speaks about vaccine studies only, nor transmission
studies, virulence studies, reassortment studies. I assume vaccine studies
are about how to manipulate the viruses that it's still antigenically the
same but replicates better in eggs or MCDK-cells. And then testing it for
efficiency and side effects
 
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