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Canada - British Columbia health statement: First confirmed positive human case of H5N1 avian influenza detected in B.C. - November 9, 2024

Canadian teen’s bird flu infection is not the version found in cows
...
By Helen Branswell Nov. 13, 2024
Senior Writer, Infectious Diseases

A Canadian teenager who is in critical condition after contracting H5N1 bird flu was infected with a version of the virus that is different from the one circulating in dairy cattle in the United States, Canadian authorities announced Wednesday.

The National Microbiology Laboratory in Winnipeg confirmed the infection was indeed caused by the H5N1 virus. But genetic sequencing showed that it is of a genotype that has been found in wild birds, not the version that has been circulating in dairy cattle in the U.S.
...
The virus that infected the Canadian teenager was a 2.3.4.4b virus of the D1.1 genotype. This version of the virus, which is spread by wild birds, has caused poultry outbreaks in a variety of places, including recently in Washington state.
...
During a press conference on Tuesday, Henry warned that while the search for the source of the infection continues, it’s possible it will never be known how the teenager contracted the virus. STAT asked if that was an attempt to be prudent or an effort to set expectations. “A bit of both,” Henry said.

However, comparing the genetic sequence of the virus from the teenager to those of known H5N1 poultry outbreaks could point to further clues, she said. “I’m more confident today than I was yesterday that we might actually find the [source], but we may not.”
...
https://www.statnews.com/2024/11/13...-infected-different-strain-than-dairy-cattle/
 
Source: https://www.statnews.com/2024/11/18/bird-flu-pandemic-h5n1-virus-mutations-canada-genomic-analysis/


H5N1 bird flu virus in Canadian teenager displays mutations demonstrating virus’ risk
The virus, which appears not to have spread to anyone else, underwent mutational changes virologists didn’t want to see
By Helen Branswell
Nov. 18, 2024
Senior Writer, Infectious Diseases

The genetic sequence of the H5N1 bird flu virus that infected a teenager in British Columbia shows that the virus had undergone mutational changes that would make it easier for that version of H5N1 to infect people, scientists who have studied the data say.

There’s currently no evidence the teenager, who remains in critical condition in hospital, infected anyone else. If that’s the case, it is likely this mutated version of the virus would die out when the teen’s illness resolves. The source of the teen’s infection has not been determined, so it’s impossible to know for sure if the mutations were in the virus that infected him or her. But scientists think it is more likely that the mutations developed during the course of his or her infection.

Still, the fact that the mutations occurred at all is a reminder that H5N1 is a dangerous virus for people, one that could potentially trigger a pandemic if it acquired the capacity to easily infect people, flu virologists say.​..
 
Source: https://vancouver.citynews.ca/2024/11/21/bc-teen-still-critical-avian-flu-risk-low/

B.C. teen avian flu patient still in critical condition; epidemiologist says risk to public low
By Michelle Meiklejohn and Charles Brockman
Posted November 21, 2024 3:39 pm.

The B.C. Ministry of Health says a teenager who was infected with H5N1, or avian flu, is still in critical condition after nearly two weeks.
On Saturday, Nov. 9, authorities shared that a teenager in the Fraser Health region had tested positive for the virus, otherwise known as bird flu.​..
 
Avian flu in B.C.: Dr. Bonnie Henry to provide update on Canada's first human case
...
Author of the article:Cheryl Chan
Published Nov 26, 2024

B.C. provincial health officer Dr. Bonnie Henry will provide an update today on the status of the teenager who was infected with H5N1 avian influenza.

Henry is holding a news conference at 11 a.m. PT. Tuesday.

In the most recent update earlier this month, Henry said the teen was in critical condition with respiratory issues in B.C. Children’s Hospital.
...

https://vancouversun.com/news/bc-update-teen-bird-flu
 
H5N1 update from BC Provincial Health Officer, Dr. Bonnie Henry

...
image.png


Scheduled for Nov 26, 2024

/https://www.youtube.com/watch?v=JH76Mi-Wntg
 
Final update on human avian influenza case in B.C.

News Release


Victoria

Tuesday, November 26, 2024 11:15 AM

Media Contacts

Andy Watson

Director of Communications
Office of the Provincial Health Officer
236 475-3094Ministry of Health

Media Relations
250 952-1887
...

An extensive, multi-agency public-health investigation into an avian influenza case involving a B.C. teenager has identified no additional cases nor evidence of human-to-human transmission.

The goals of the investigation were to identify any contacts who may have had exposure to the teenager, determine the source of exposure, and ensure that there was no risk of new infections from either the teenager or animal sources. The investigation also included testing of household pets, birds and other animals from nearby premises, and environmental (soil, water) testing.

To date, all tests on humans, animals and environmental samples related to this investigation have been negative for influenza H5. While it is reassuring that no further cases have been identified, officials have also not been able to definitively identify the source of the young person’s infection.

The investigation has determined the teenager was infected with the same strain of influenza H5N1 currently circulating in wild birds and poultry in B.C.(Clade 2.3.4.4b, Genotype D1.1). Advanced testing at the BC Centre for Disease Control (BCCDC) Public Health Laboratory determined the whole genome sequence of the virus most closely matches that of wild birds found in the Fraser Valley area in October and was not directly related to outbreaks at poultry farms in B.C.

“Our thoughts continue to be with this young person as they remain in critical condition, and their family,” said Dr. Bonnie Henry, B.C.’s provincial health officer. “I am confident in the extensive public health investigation that was led by the Fraser Health team in partnership with the BCCDC Public Health Laboratory, our partners at BC Children’s Hospital and the chief veterinary officer. Though we have not been able to determine definitively the source of exposure, we were able to rule out many potential risks and ensure there are no further cases related to this young person.”

While this was the first case of H5N1 in a person in B.C. and the first acquired in Canada, there have been a small number of human cases in the U.S. this year, including one reported in a child in California last week.

Health, animal and environmental partners across B.C. have also been working together and with the Canadian Food Inspection Agency and other national and U.S. partners to respond to the increased detections of H5N1 avian influenza in poultry farms and wild birds in the province since early October.

Prevention measures
To protect yourself against avian influenza, the following prevention measures are recommended:
  • Stay up to date on all immunizations, especially the seasonal flu vaccine.
  • Do not touch sick or dead animals or their droppings and do not bring sick wild animals into your home.
  • Keep your pets away from sick or dead animals and their feces.
  • Report dead or sick birds or animals.
    • For poultry or livestock, contact the Canadian Food Inspection Agency (CFIA) Animal Health office: https://inspection.canada.ca/en/about-cfia/contact-cfia-office-telephone
    • For pets, contact your veterinarian or call the BC Animal Health Centre at 1 800 661-9903
    • For wild birds, contact the BC Wild Bird Mortality Line: 1 866 431-2473
    • For wild mammals, contact the BC Wildlife Health Program: 1 250 751-7246
If you have been exposed to sick or dead birds or animals or work on farm where avian influenza has been detected, watch for symptoms of influenza-like illness. If you get symptoms within 10 days after exposure to sick or dead animals, tell your health-care provider that you have been in contact with sick animals and are concerned about avian influenza. This will help them give you appropriate advice on testing and treatment. Stay home and away from others while you have symptoms.

About avian influenza
Avian influenza viruses occur naturally among wild aquatic birds and spread easily from bird to bird. Since 2022, there has been unprecedented global spread of avian influenza caused by the H5N1 virus. While it mostly affects birds, it can affect other animals too. In addition to cases reported in wild birds and poultry farms in North America, the virus has infected mammals including dairy cattle, foxes, skunks, marine mammals and more. There have also been isolated reports of H5N1 detections in goats and in a pig in the United States. There have also been reports of cases in humans, notably following exposure to infected animals.

In B.C., H5N1 has been detected in wild birds, on poultry farms and among small wild mammals, including skunks and foxes. Most cases have been reported during migration season when wild birds carrying the virus are in high numbers in B.C. Since the beginning of October 2024, at least 54 infected poultry premises have been identified in B.C., along with numerous wild birds testing positive.

In B.C. and Canada, there have been no cases reported in dairy cattle and no evidence of avian influenza in samples of milk.

Influenza viruses are adaptable and can change when strains from humans or different animal species mix and exchange genetic information. Avian influenza could become more serious if the virus develops the ability to transmit from person to person, with potential for human-to-human transmission.

Learn More:

Ministry of Agriculture and Food information on avian influenza: https://www2.gov.bc.ca/gov/content/...rtable-notifiable-diseases/avian-influenza-ai

BC Centre for Disease Control information on avian influenza: http://www.bccdc.ca/health-info/diseases-conditions/avian-influenza

Avian influenza: How can I protect myself? http://www.bccdc.ca/resource-gallery/Documents/Avian_flu_How_can_I_protect_myself.pdf

HealthLinkBC information on avian influenza: https://www.healthlinkbc.ca/illnesses-conditions/infectious-diseases/avian-influenza

Public Health Agency of Canada information on avian influenza: https://www.canada.ca/en/public-health/services/diseases/avian-influenza-h5n1.html

WorkSafeBC information on avian influenza: https://www.worksafebc.com/en/health-safety/injuries-diseases/infectious-diseases/types/avian-flu


https://news.gov.bc.ca/releases/2024HLTH0155-001601
 
Influenza cases at seasonal levels ahead of holidays, but bird flu raising concerns
...
Alanna Smith, Globe and Mail
about an hour ago
...
“The recent evolution of bird flu is a real concern,” said Dr. Brinkman, who tracks the evolution of avian flu viruses. She said the D1.1 genotype of H5N1, which severely sickened a patient in Louisiana this week and a British Columbia teenager last month, and the unrelated discovery this year of bird flu in cows in the United States are cause for caution.
...
The H5N1 virus has not yet been detected in Canadian cattle. Both the B.C. and Louisiana cases are believed to be connected to birds.
...
The B.C. young person was in critical condition but their current status is unknown. The province declined to give an update on the teenager’s case on Thursday.

There is no evidence of sustained human-to-human transmission of avian flu and health officials across Canada have stressed that the risk to the general public remains low despite widespread infections detected in domestic and wild birds.

“But this is the first winter where we’re going to have seasonal flu mixing with that flu and we’re just not sure what’s going to happen,” said Dr. Brinkman. She said there is potential for a reassortment virus, which is created when two or more viruses mix with one another and create a new infective agent.
...
https://www.rmoutlook.com/beyond-lo...olidays-but-bird-flu-raising-concerns-9985765
 
Source: https://www.nejm.org/doi/full/10.1056/NEJMc2415890

Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection
Published December 31, 2024


To the Editor:
Highly pathogenic avian influenza A(H5N1) viruses are circulating among wild birds and poultry in British Columbia, Canada.1 These viruses are also recognized to cause illness in humans. Here, we report a case of critical illness caused by influenza A(H5N1) virus infection in British Columbia.
On November 4, 2024, a 13-year-old girl with a history of mild asthma and an elevated body-mass index (the weight in kilograms divided by the square of the height in meters) of greater than 35 presented to an emergency department in British Columbia with a 2-day history of conjunctivitis in both eyes and a 1-day history of fever. She was discharged home without treatment, but cough, vomiting, and diarrhea then developed, and she returned to the emergency department on November 7 in respiratory distress with hemodynamic instability. On November 8, she was transferred, while receiving bilevel positive airway pressure, to the pediatric intensive care unit at British Columbia Children’s Hospital with respiratory failure, pneumonia in the left lower lobe, acute kidney injury, thrombocytopenia, and leukopenia (Table S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org). A nasopharyngeal swab obtained at admission was positive for influenza A but negative for A(H1) and A(H3) by the BioFire Respiratory Panel 2.1 assay (BioFire Diagnostics). Reflex testing of the specimen with the Xpert Xpress CoV-2/Flu/RSV plus assay (Cepheid) revealed an influenza A cycle threshold (Ct) value of 27.1. This finding indicates a relatively high viral load for which subtyping would be expected; the lack of subtype identification suggested infection with a novel influenza A virus. Oseltamivir treatment was started on November 8 (Table S2), and the use of eye protection, N95 respirators, and other precautions against droplet, contact, and airborne transmission were implemented.​...
 
[from previous post, #28]

...
The virus was typed as clade 2.3.4.4b, genotype D1.1,[SUP]4[/SUP] most closely related to viruses detected in wild birds in British Columbia around the same time (Fig. S2). Markers of adaptation to humans were detected in the tracheal-aspirate specimen collected on November 9: the E627K mutation was detected (52% allele frequency) in the polymerase basic 2 (PB2) gene product, and analysis of the H5 hemagglutinin (HA) gene yielded ambiguous calls in the codons for amino acid residues E186 (E190 according to H3 mature HA numbering) — 28% allele frequency for E186D — and Q222 (Q226 according to H3 mature HA numbering) — 35% allele frequency for Q222H. The mutations in the H5 HA gene have previously been shown to increase binding to α2-6–linked sialic acids, which act as receptors that facilitate viral entry into cells in the human respiratory tract and enable viral replication.[SUP]5[/SUP]

Highly pathogenic avian influenza A(H5N1) virus infection acquired in North America can cause severe human illness. Evidence for changes to HA that may increase binding to human airway receptors is worrisome.​
 
B.C. teen with avian flu discharged after weeks in hospital

​ Posted: January 9, 2025 4:28 PM​

B.C. Children's Hospital says a 13-year-old girl with avian flu was discharged Tuesday after weeks in hospital.
The patient was taken to a pediatric intensive care unit with respiratory failure and pneumonia on Nov. 8, and health officials said she tested positive for H5N1 a day later.

A recent medical journal chronicled the teen's hospitalization in Vancouver, which involved tracheal intubation and supplemental oxygen.
Her family says in a statement that the experience has been "life-changing" and that they are grateful to have their daughter home.
-snip-

The B.C. Centre for Disease Control said it was comparing the genetic features of the local teenager's avian flu case with that of a patient in Louisiana hospitalized with a severe case of avian flu who died earlier this month.

Clinical microbiologist Dr. Agatha Jassem, co-program head of the virology lab at the BCCDC Public Health Laboratory, says they want to understand how the viruses in the two cases are related to each other, as well as to viruses circulating in birds.

This will help to assess how easily it adapts and transmits between animals and humans. Both cases are related to viruses detected in wild birds and poultry. While there is no evidence of human-to-human infection in either, it's something experts are keeping an eye on.
Jassem says the U.S. patient shared one of the three genetic mutations identified in the Canadian case, which infectious disease specialists have said could make it easier for the virus to spread from person to person.
The lab is testing samples collected on different days with a variety of methods to determine how the mutations affect replication of the virus in human airways.​

https://www.cbc.ca/lite/story/1.7427391
 
B.C. doctor reflects on treating teen with H5N1 for 2 months

​January 13, 2025​
Excerpt:

...
Dr. David Goldfarb, a medical microbiologist and pediatric infectious disease physician at B.C. Children's Hospital first saw the young patient on Nov. 8.
She was in respiratory distress, but there was no "clear flag" that suggested she was infected with H5N1. Goldfarb sent diagnostic tests to the hospital lab to determine the type of influenza that had sickened the teen. They all came back negative.

Occasionally, he said this happens if the sample is weak with a very small amount of the virus in it.
But it wasn't a weak sample. It was actually reasonably strong, he said.
As Goldfarb took a closer look at the case, he started to notice symptoms associated with recent cases of avian flu, such as pink eye and wanted to test his theory as soon as possible.
"I called my colleague at the B.C. Centre for Disease Control and arranged for urgent testing for the H5N1 test, which is for the avian flu strain. That was done that same day, and we had that result by the evening of the admission to our hospital," Goldfarb said.
The result was positive and was the first human case of H5N1 in Canada.

Continued: https://www.cbc.ca/lite/story/1.7430242
 
Translation Google

La Presse in British Columbia

In the epicenter of bird flu in the country

Avian flu is hitting British Columbia hard, making it one of the hardest-hit regions in North America. Infections among wild birds are reaching record levels, and farmers are on alert. And for the first time, a teenage girl nearly died after contracting the virus. A report by Alice Girard-Bossé.

Posted at 5:00 AM

(Vancouver) On November 8, when he was given a sample for analysis, Dr. David Goldfarb expected a case of seasonal flu, the kind he sees every year. At first glance, there was nothing to suggest that the 13-year-old girl in respiratory distress actually had avian flu.

Posted at 5:00 AM
Alice Girard-Bossé
La Presse

That day, the teenager arrived at BC Children's Hospital in the heart of Vancouver in dire condition: suffering from a cough, vomiting, and diarrhea. She was rushed to intensive care.

"I thought she had the flu. It wasn't the peak of flu season yet, but we were still seeing a few cases a week. It wasn't unusual," says David Goldfarb, a medical microbiologist and pediatric infectious disease physician.

Dr. David Goldfarb tested for seasonal flu and found it negative. Intrigued, he looked through the teenager's file. Seeing that she had conjunctivitis, he immediately made the connection .

"The vast majority of people infected with bird flu in the United States also had conjunctivitis."
- Dr. David Goldfarb, medical microbiologist and pediatric infectious disease physician

Four days earlier, the teenager had gone to the hospital with conjunctivitis and a fever, but was sent home without receiving treatment.

Even before receiving the results of the additional tests, Dr. Goldfarb rushed to the intensive care unit and ordered increased infection prevention measures. The teenager was placed in a negative-pressure room, where contaminated air is filtered, to prevent any spread.

Then he contacted his colleagues at the British Columbia Centre for Disease Control and arranged for the sample to be sent. The result came back that same evening: the girl was indeed suffering from H5N1 avian flu, the most common subtype of the virus among birds in Canada.

The National Microbiology Laboratory has confirmed the diagnosis: for the first time, a human being has contracted H5N1 avian flu in Canada.

A virus that circulates and changes

Avian influenza primarily affects birds and can spread rapidly, especially in commercial flocks, through direct contact with infected birds or their droppings.

The H5N1 strain has been circulating in Canada since 2022. In total, more than 8 million domestic birds have been infected in British Columbia, 2 million in Alberta, and Quebec ranks third with 1.4 million, according to the Canadian Food Inspection Agency.

A federal judge has granted a stay of execution for some 400 ostriches scheduled to be slaughtered at the end of January at a farm in Edgewood, British Columbia, affected by bird flu.

Most provinces have seen a decline in the number of infections since 2022, but British Columbia is an exception. Last year, the province detected more traces of the virus in wild birds than ever before, and a record number of poultry farms were affected.

Our neighbors to the south are not spared. In one year, avian flu has led to the culling of 166 million farm birds in the United States. Worse still, it was discovered for the first time this year that the virus can also be transmitted to cattle. Hundreds of dairy herds have been affected, as have dozens of humans.

Avian flu has the ability to change genetically rapidly, leading to the emergence of numerous variants.

Avian influenza infections remain relatively rare in humans, but can cause severe symptoms (fever, cough, muscle aches, and breathing problems), which can lead to death. Since 1997, approximately 900 cases have been reported worldwide.

The main concern is that the virus could mutate and bird flu could then spread from human to human, potentially triggering a new pandemic. "Then we would have a catastrophe," says John Swartzberg, a professor at the University of California, Berkeley's School of Public Health.

Avoid new cases

The 13-year-old spent nearly two months in hospital before being discharged in early January. Despite Public Health investigations, it remains unclear where she contracted the virus. However, it appears she was infected with the same virus variant found in wild birds in British Columbia.

"British Columbia has a high incidence of avian influenza in wild birds and poultry, so we should expect another human case."
- Dr. David Goldfarb

To prevent future cases, Canada acquired a bird flu vaccine in mid-February to protect at-risk individuals, such as agricultural workers: the country has 500,000 doses.

Large-scale vaccination is off the table for now, but Ottawa is urging provinces to offer it to people at particular risk from the virus.

https://www.lapresse.ca/actualites/...s/2025-03-16/une-province-sur-le-qui-vive.php
 
Translation Google

Bird flu in a teenage girl: emails reveal "a widespread reaction"

Melinda Trochu
Published yesterday at 7:44 AM CST

On November 9, 2024, British Columbia announced the first presumptive case of H5 avian influenza contracted in Canada by a human . Media outlets worldwide quickly took notice, given the disease's pandemic potential .

With fatalities potentially reaching 50%, particularly among younger people, no country wants to be the epicenter of human-to-human transmission and a new pandemic.

British Columbia's chief medical officer of health, Bonnie Henry, remembers those early days, when there was inevitably a lot of concern .

We had prepared ourselves for the possibility of transmission to humans, particularly to people working on poultry farms. However, it was quite unusual to learn that it involved a young woman who, to our knowledge, did not live on a poultry farm.
A quote fromBonnie Henry, Chief Medical Officer of Health for British Columbia

Upon the arrival of a positive result from a flu screening test, excluding the usual H3 and H1, a process is triggered to inform people very quickly .

[It's] a general reaction. Absolutely.
A quote from Bonnie Henry, Chief Medical Officer of Health for British Columbia

Radio-Canada obtained, through an access to information request, 278 pages of emails from the provincial Ministry of Health. These reflect the coordination of the first few days, particularly while awaiting confirmation from the National Microbiology Laboratory in Winnipeg, which would be announced several days later .

Six days in the community

Although in the first few weeks the media only had access to certain information, we now know that the teenager infected in the Fraser Valley developed symptoms on November 2, went to Surrey Memorial Hospital on the 4th , was sent home, then returned there on November 7 in respiratory distress .

On November 8, she was transferred to a pediatric intensive care unit at BC Children's Hospital. A test that day revealed the presence of the H5 virus.

She has just spent six days in the community without a diagnosis, carrying a virus monitored globally for its pandemic potential.

Friday, November 8: All hands on deck in the evening

That same evening, the medical director of preventive clinical services at the British Columbia Centre for Disease Control sent a highly important email to arrange a conference call. The goal was to inform key individuals on that Friday evening, on the eve of a long weekend.

Several people are absent, so we may not have everyone available.
A quote from Email request for access to information

Another email mentions: It would appear that this is the first case in Canada.

That evening, doctors set about developing a plan, including what to tell the family regarding isolation and contacting the Chief Veterinarian's Office .

Public health officials will contact the family [Saturday] morning to determine who their contacts have been and who they should contact.

At 11:15 p.m., an email states that the Fraser Health Authority will contact the family's contacts, that nasopharyngeal swabs should be preferred, and that prophylaxis should be offered.

We will also follow up with [redacted part]; potential occupational exposure and exposure to other patients during admission and previous visits to the emergency department.
A quote from Email request for access to information

Information contained in the emails has not been made public due to, among other things, the risk of damaging disclosure:
to the application of the law;
to intergovernmental relations or negotiations;
to the financial or economic interests of a public body;
to individual or public safety;
to privacy.

Saturday, November 9: The media have been notified.

The following day, at 8:58 a.m., communications officials from the Pan-Canadian Public Health Network and Health Canada were alerted by British Columbia. A public health advisory was expected to be issued later, although details were still being finalized and numerous partners were involved .

Your case will be the first human-acquired case in Canada.
A quote from Email from the Director of the Public Affairs and Communications Branch, Health Canada

In the early afternoon, Health Canada advised British Columbia, after discussions with the Winnipeg Laboratory, to report that this was a confirmed case of H5 based on the test.PCR but that there will be a more in-depth analysis of a sample to be sent to Manitoba.

In Victoria, prior to the release of the press release, there was a debate about whether to mention the Fraser Health Authority , a choice that ultimately fell to the Chief Medical Officer of Health, Bonnie Henry .

The standard practice is to name the relevant authority to alleviate concerns from other parts of British Columbia . In this particular case, it was agreed not to go into too much detail given the concerns expressed by parents .

Minutes before the release of the press release, which finally does mention the Fraser region , the communications director of Bonnie Henry 's office is already anticipating media interest: "And then, my phone is not going to stop ringing 😉."

While Dr. Henry thought the media might take some time to react given that most media outlets don't have many staff working weekends , reporters were already requesting interviews as early as Saturday afternoon.

Sunday, November 10: The Special Access Program

On Sunday morning, we learned that contacts in the community are being monitored and have been offered prophylactic measures.

A problem with access to a medication seems to be emerging. Part of a sentence is not public, but it reads: always delayed due to problems related to SAP [sic] and where one can access the medication .

SAP refers to the Special Access Program (SAP) which allows health professionals to access drugs and medical devices that are not yet commercially available for sale in Canada.

It is reported that the BC Children's Hospital is in contact with the CDC American, then further on: We are working to get SAP [sic] from Health Canada to Roche.

In the afternoon, a reporter requests an interview about advice to give to worried parents who have been or are still at the Children's Hospital. Another wants to address the concerns of parents in the Fraser region as their children prepare to return to school the following Tuesday.

The director of media relations for the Provincial Health Services Authority (PHSA) then wrote: It is important, I think, to inform people of the security measures in place (as usual) and to remind them that it is always safe to go to the hospital.

We also learn that a problem accessing Tamiflu has been resolved for some contact cases and that recourse to the provincial reserve was not necessary.

However, a problem related to the fax machine was mentioned in the evening.

There are connection problems with the pharmacy: a prescription by fax is required. Can a verbal order be accepted?
A quote from Email request for access to information

At that time, 26 contact cases were mentioned, half of which had not yet been contacted .

Monday, November 11: a public holiday that's anything but restful

On Monday, one of the difficulties arising from the emails concerned the sample that was to be sent to the Winnipeg Laboratory to confirm the British Columbia test.

It was supposed to be sent on an Air Canada flight departing Vancouver at 8:10 a.m. and arriving in Winnipeg at 12:58 p.m. However, the sample did not make it onto that plane. It finally arrived at the Winnipeg laboratory on Tuesday at 9:00 a.m. on a Cargojet flight .​

In the afternoon, there appeared to be communication problems between the different levels of government. British Columbia then requested that the federal government receive a copy of the comments from any other federal agency commenting on the matter, in order to ensure consistency in communications .

"Health Canada's statement surprised us somewhat."

Early in the evening, while awaiting results from Winnipeg, the director of communications for the Office of the Provincial Medical Officer of Health explained to a CNN reporter that it was a presumptive positive case of H5 .

In the evening, contact tracing became one of the problems.

Ongoing issue: notification and support of occupationally exposed individuals. Contact is difficult; the team is continuing its efforts.
A quote from Email request for access to information

At Surrey Hospital , approximately 18 people are affected. At the Children's Hospital, it's around 26. The team hopes to complete the contact tracing on Tuesday.

The source of the contamination is still unknown, but several teams are ready to contribute their resources if needed. At 4 p.m., it was understood that the interview with the family had concluded and that a site visit was being arranged.

Tuesday, November 12: a highly anticipated press conference

On Tuesday, as children returned to schools in the Fraser region , the head of provincial digital solutions for the PHSA questions whether the case and contact tracing system or the Panorama system needs to be adjusted .

Panorama is an integrated electronic public health record system. It is used in British Columbia by public health professionals to support the management of communicable diseases, outbreaks, immunizations, and vaccine stockpiles.

[There have been] some modifications to the CST Cerner software, given that this child's case is being treated at the Children's Hospital.

CST Cerner software is an electronic health record system.

Before the press conference, Dr. Bonnie Henry and Dr. Elizabeth Brodkin agreed to add to the advice for schools that visits to educational farms [...] should not be part of school activities at present .

At 11:30 a.m., Dr. Bonnie Henry held a press conference attended by international media outlets such as CNN , the Associated Press , and the Washington Post .

The main messages to be conveyed, which can be read in the emails, should allow for preparation for questions about Canada's pandemic preparedness and whether there is an emphasis on obtaining details about the patient .

At 3:52 p.m., a letter was sent to the superintendents. The only sentence in bold was: No cases of exposure have been identified in any school.

On the morning of November 13, more than 40 media requests were received. During the night, the Winnipeg Laboratory confirmed the contamination.H5N1.

Source unknown

To date, the source of the contamination remains unknown. No other people have been infected.

The teenager was no longer contagious from November 29th and no longer needed respiratory assistance from December 18th. She survived, but she nevertheless spent two months in the hospital .
I am really happy that she received such good care and survived, but it has been a very traumatic time for her family , says Dr. Bonnie Henry .

The public health officer assures that British Columbia detected this rare event , thanks in particular to the PCRMultiplex, a test that allows screening for 5 respiratory diseases.

She also congratulated the province for being able to sequence the entire genome of this virus and determine its relationship , which provided a relief by showing that the virus was actually much closer to certain wild birds .

The system we have put in place to monitor people with respiratory illnesses, particularly if their condition is serious enough that they seek medical help, is working.

However, even if this story has a happy ending, Dr. Bonnie Henry knows there will be another virus . In public health, she says, a balance must be struck so that people can go about their daily lives , while also emphasizing the importance of prevention and vaccination.

We have big events coming up, such as the FIFA World Cup next summer, and we need to make sure we are able to detect any potential problems.
A quote from Bonnie Henry, Chief Medical Officer of Health for British Columbia

According to data from the WHO from December 19th (new window)mortality due toH5N1over the past four years has amounted to 16.28%. These rates may reflect both the nature of the report [...] and the actual severity of the illness .

Even if the case fatality rate fluctuates, a pandemic of H5N1would wreak havoc, hence the vital importance of rapid detection of cases and mutations.

Nearly a century ago, the H1N1 pandemic, one of the deadliest in history, had a mortality rate of around 2% .


https://ici.radio-canada.ca/info/lo...cente-echanges-ministere-sante-grippe-aviaire
 
Lancet Infect Dis . Management of critical illness in an adolescent caused by highly pathogenic avian influenza A(H5N1) virus infection in British Columbia, Canada

Lancet Infect Dis


. 2026 Jan 20:S1473-3099(25)00773-X.
doi: 10.1016/S1473-3099(25)00773-X. Online ahead of print.
Management of critical illness in an adolescent caused by highly pathogenic avian influenza A(H5N1) virus infection in British Columbia, Canada

Elspeth MacBain[SUP] 1 [/SUP], Ashraf Znait[SUP] 1 [/SUP], Linda Edwards[SUP] 1 [/SUP], Agatha Jassem[SUP] 2 [/SUP], Vilte E Barakauskas[SUP] 1 [/SUP], Kevin C Harris[SUP] 1 [/SUP], Sarah Lohrenz[SUP] 1 [/SUP], Sareh Zahedieh[SUP] 3 [/SUP], Nathalie Bastien[SUP] 4 [/SUP], Charlene Ranadheer[SUP] 4 [/SUP], Cherry Mammen[SUP] 1 [/SUP], Roxana Azma[SUP] 1 [/SUP], Audi Setiadi[SUP] 1 [/SUP], Jonathan H Rayment[SUP] 1 [/SUP], Nicolas Mourad[SUP] 5 [/SUP], Ryaan El-Andari[SUP] 6 [/SUP], Timothy M Uyeki[SUP] 7 [/SUP], Lynne Li[SUP] 1 [/SUP], Ashley Roberts[SUP] 1 [/SUP], Muheildin A Muheildin[SUP] 1 [/SUP], David M Goldfarb[SUP] 8 [/SUP]


Affiliations
Abstract

Highly pathogenic avian influenza A(H5N1) viruses have been circulating among wild birds and are enzootic in poultry in some areas of the world with spillover to a wide range of terrestrial and marine mammals. Since 1997, sporadic animal to human, primarily poultry to human, transmission of highly pathogenic avian influenza A(H5N1) viruses has been reported in 25 countries. More recently there have been locally acquired infections in the Americas due to the 2.3.4.4b clade of the virus. Most of the recently detected human infections in the USA have been relatively mild but there have been cases of critical illness reported in several countries. In this Grand Round we present the first locally acquired highly pathogenic avian influenza A(H5N1) virus infection in Canada, which was in a 13-year-old female, who developed severe disease requiring prolonged critical care. She was infected with a clade 2.3.4.4b, genotype D1.1 virus and developed evidence of cytokine storm and received several modalities of care including combination antiviral therapy, renal replacement therapy, therapeutic plasma exchange, and invasive mechanical ventilation support with veno-venous extracorporeal life support. She recovered and was discharged home without requirement for additional support. This Grand Round describes important clinical and management considerations for critically ill patients infected with highly pathogenic avian influenza A(H5N1) virus.


 
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