tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2012 Jun 5. doi: 10.1111/j.1469-0691.2012.03936.x. [Epub ahead of print]
Can infants be protected by means of maternal vaccination?
Esposito S, Bosis S, Morlacchi L, Baggi E, Sabatini C, Principi N.
Source
Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universit? degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Abstract
Clin Microbiol Infect 2012; 18(Suppl. 5): 1-8 ABSTRACT: The administration of vaccines is not usually recommended in pregnant women because of a fear of severe adverse events for the fetus. However, contraindication to vaccination applies only to vaccines based on live attenuated viruses for the theoretical possibility that they might infect the fetus. In contrast, the use of several inactivated vaccines is useful and recommended. As a result of the transplacental passage of antibodies, maternal immunization can reduce the risk of vaccine-preventable diseases that may occur in the first months of life before the start or completion of the suggested vaccination schedule. One of the best examples is vaccination against influenza that can protect pregnant women from a disease that can lead to hospitalization and death in a significantly higher number of cases than in the general population and can induce protective specific antibody levels as well as being effective in infants in the first months of life. Other examples are vaccinations against tetanus, pertussis, pneumococcal infections and Haemophilus influenzae type b infection. This review analyses the advantages and limitations of maternal immunization as revealed by experience and the main publications.
? 2012 The Authors. Clinical Microbiology and Infection ? 2012 European Society of Clinical Microbiology and Infectious Diseases.
PMID:
22862749
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22862749
Can infants be protected by means of maternal vaccination?
Esposito S, Bosis S, Morlacchi L, Baggi E, Sabatini C, Principi N.
Source
Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universit? degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Abstract
Clin Microbiol Infect 2012; 18(Suppl. 5): 1-8 ABSTRACT: The administration of vaccines is not usually recommended in pregnant women because of a fear of severe adverse events for the fetus. However, contraindication to vaccination applies only to vaccines based on live attenuated viruses for the theoretical possibility that they might infect the fetus. In contrast, the use of several inactivated vaccines is useful and recommended. As a result of the transplacental passage of antibodies, maternal immunization can reduce the risk of vaccine-preventable diseases that may occur in the first months of life before the start or completion of the suggested vaccination schedule. One of the best examples is vaccination against influenza that can protect pregnant women from a disease that can lead to hospitalization and death in a significantly higher number of cases than in the general population and can induce protective specific antibody levels as well as being effective in infants in the first months of life. Other examples are vaccinations against tetanus, pertussis, pneumococcal infections and Haemophilus influenzae type b infection. This review analyses the advantages and limitations of maternal immunization as revealed by experience and the main publications.
? 2012 The Authors. Clinical Microbiology and Infection ? 2012 European Society of Clinical Microbiology and Infectious Diseases.
PMID:
22862749
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22862749