tetano
Editor, Senior Moderator
Org Lett. 2012 Feb 17. [Epub ahead of print]
[C+NC+CC] Coupling-Enabled Synthesis of Influenza Neuramidase Inhibitor A-315675.
Garner P, Weerasinghe L, Youngs WJ, Wright B, Wilson D, Jacobs D.
Source
Department of Chemistry, Washington State University, Pullman, Washington 99164-4630, United States, Department of Chemistry, University of Akron, Akron, Ohio 44325, United States, and Vertex Pharmaceuticals Inc., Cambridge, Massachusetts 02139, United States.
Abstract
An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.
PMID:
22339284
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22339284
[C+NC+CC] Coupling-Enabled Synthesis of Influenza Neuramidase Inhibitor A-315675.
Garner P, Weerasinghe L, Youngs WJ, Wright B, Wilson D, Jacobs D.
Source
Department of Chemistry, Washington State University, Pullman, Washington 99164-4630, United States, Department of Chemistry, University of Akron, Akron, Ohio 44325, United States, and Vertex Pharmaceuticals Inc., Cambridge, Massachusetts 02139, United States.
Abstract
An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.
PMID:
22339284
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22339284