tetano
Editor, Senior Moderator
Bioorg Med Chem. 2012 Oct 22. pii: S0968-0896(12)00772-9. doi: 10.1016/j.bmc.2012.09.051. [Epub ahead of print]
C-3 halo and 3-methyl substituted 5'-nor-3-deazaaristeromycins: Synthesis and antiviral properties.
Liu C, Chen Q, Yang M, Schneller SW.
Source
Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849-5312, United States.
Abstract
To expand on the antiviral properties of 5'-noraristeromycin, synthetic entry into 3-substituted 3-deaza-5'-noraristeromyin derivatives (i.e., bromo, 4; iodo, 5; chloro, 6; and, methyl, 7) has been accomplished from a common intermediate. An extensive antiviral analysis showed 7 to be basically inactive (except for weak effects against VSV) and there were no general trends among the halo compounds (except versus reovirus-1 and influenza B). Individually, compound 4 was most favorable towards HCMV, VZV, HBV, and VV; product 5 against HBV, VSV, VV, influenza B, HCMV, and measles; and, target 6 towards Punta Toro, VSV, measles, parainflucenza-3, influenza A (H5N1), and influenza B. The methyl target 7 was inactive in all viral assays.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
23176752
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23176752
C-3 halo and 3-methyl substituted 5'-nor-3-deazaaristeromycins: Synthesis and antiviral properties.
Liu C, Chen Q, Yang M, Schneller SW.
Source
Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849-5312, United States.
Abstract
To expand on the antiviral properties of 5'-noraristeromycin, synthetic entry into 3-substituted 3-deaza-5'-noraristeromyin derivatives (i.e., bromo, 4; iodo, 5; chloro, 6; and, methyl, 7) has been accomplished from a common intermediate. An extensive antiviral analysis showed 7 to be basically inactive (except for weak effects against VSV) and there were no general trends among the halo compounds (except versus reovirus-1 and influenza B). Individually, compound 4 was most favorable towards HCMV, VZV, HBV, and VV; product 5 against HBV, VSV, VV, influenza B, HCMV, and measles; and, target 6 towards Punta Toro, VSV, measles, parainflucenza-3, influenza A (H5N1), and influenza B. The methyl target 7 was inactive in all viral assays.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
23176752
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23176752