tetano
Editor, Senior Moderator
Clin Infect Dis. 2017 Aug 9. doi: 10.1093/cid/cix565. [Epub ahead of print]
[h=1]Burden of Influenza in 4 Ecologically Distinct Regions of Peru: Household Active Surveillance of a Community Cohort, 2009-2015.[/h] Tinoco YO[SUP]1,[/SUP][SUP]2[/SUP], Azziz-Baumgartner E[SUP]3[/SUP], Uyeki TM[SUP]3[/SUP], R?zuri HR[SUP]1[/SUP], Kasper MR[SUP]1[/SUP], Romero C[SUP]1[/SUP], Silva ME[SUP]1[/SUP], Simons MP[SUP]1[/SUP], Soto GM[SUP]1[/SUP], Widdowson MA[SUP]3[/SUP], Gilman RH[SUP]2[/SUP], Bausch DG[SUP]1,[/SUP][SUP]4[/SUP], Montgomery JM[SUP]1,[/SUP][SUP]5[/SUP]; Peru Influenza Cohorts Working Group.
[h=3]Collaborators (13)[/h]
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] There are limited data on the burden of disease posed by influenza in low- and middle-income countries. Furthermore, most estimates of influenza disease burden worldwide rely on passive sentinel surveillance at health clinics and hospitals that lack accurate population denominators.
[h=4]Methods:[/h] We documented influenza incidence, seasonality, health-system utilization with influenza illness, and vaccination coverage through active community-based surveillance in 4 ecologically distinct regions of Peru over 6 years. Approximately 7200 people in 1500 randomly selected households were visited 3 times per week. Naso- and oropharyngeal swabs were collected from persons with influenza-like illness and tested for influenza virus by real-time reverse-transcription polymerase chain reaction.
[h=4]Results:[/h] We followed participants for 35353 person-years (PY). The overall incidence of influenza was 100 per 1000 PY (95% confidence interval [CI], 97-104) and was highest in children aged 2-4 years (256/1000 PY [95% CI, 236-277]). Seasonal incidence trends were similar across sites, with 61% of annual influenza cases occurring during the austral winter (May-September). Of all participants, 44 per 1000 PY (95% CI, 42-46) sought medical care, 0.7 per 1000 PY (95% CI, 0.4-1.0) were hospitalized, and 1 person died (2.8/100000 PY). Influenza vaccine coverage was 27% among children aged 6-23 months and 26% among persons aged ≥65 years.
[h=4]Conclusions:[/h] Our results indicate that 1 in 10 persons develops influenza each year in Peru, with the highest incidence in young children. Active community-based surveillance allows for a better understanding of the true burden and seasonality of disease that is essential to plan the optimal target groups, timing, and cost of national influenza vaccination programs.
[h=4]KEYWORDS:[/h] community cohort; healthcare-seeking behavior; household-based; influenza; seasonality
PMID: 29020267 DOI: 10.1093/cid/cix565
[h=1]Burden of Influenza in 4 Ecologically Distinct Regions of Peru: Household Active Surveillance of a Community Cohort, 2009-2015.[/h] Tinoco YO[SUP]1,[/SUP][SUP]2[/SUP], Azziz-Baumgartner E[SUP]3[/SUP], Uyeki TM[SUP]3[/SUP], R?zuri HR[SUP]1[/SUP], Kasper MR[SUP]1[/SUP], Romero C[SUP]1[/SUP], Silva ME[SUP]1[/SUP], Simons MP[SUP]1[/SUP], Soto GM[SUP]1[/SUP], Widdowson MA[SUP]3[/SUP], Gilman RH[SUP]2[/SUP], Bausch DG[SUP]1,[/SUP][SUP]4[/SUP], Montgomery JM[SUP]1,[/SUP][SUP]5[/SUP]; Peru Influenza Cohorts Working Group.
[h=3]Collaborators (13)[/h]
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] There are limited data on the burden of disease posed by influenza in low- and middle-income countries. Furthermore, most estimates of influenza disease burden worldwide rely on passive sentinel surveillance at health clinics and hospitals that lack accurate population denominators.
[h=4]Methods:[/h] We documented influenza incidence, seasonality, health-system utilization with influenza illness, and vaccination coverage through active community-based surveillance in 4 ecologically distinct regions of Peru over 6 years. Approximately 7200 people in 1500 randomly selected households were visited 3 times per week. Naso- and oropharyngeal swabs were collected from persons with influenza-like illness and tested for influenza virus by real-time reverse-transcription polymerase chain reaction.
[h=4]Results:[/h] We followed participants for 35353 person-years (PY). The overall incidence of influenza was 100 per 1000 PY (95% confidence interval [CI], 97-104) and was highest in children aged 2-4 years (256/1000 PY [95% CI, 236-277]). Seasonal incidence trends were similar across sites, with 61% of annual influenza cases occurring during the austral winter (May-September). Of all participants, 44 per 1000 PY (95% CI, 42-46) sought medical care, 0.7 per 1000 PY (95% CI, 0.4-1.0) were hospitalized, and 1 person died (2.8/100000 PY). Influenza vaccine coverage was 27% among children aged 6-23 months and 26% among persons aged ≥65 years.
[h=4]Conclusions:[/h] Our results indicate that 1 in 10 persons develops influenza each year in Peru, with the highest incidence in young children. Active community-based surveillance allows for a better understanding of the true burden and seasonality of disease that is essential to plan the optimal target groups, timing, and cost of national influenza vaccination programs.
[h=4]KEYWORDS:[/h] community cohort; healthcare-seeking behavior; household-based; influenza; seasonality
PMID: 29020267 DOI: 10.1093/cid/cix565