tetano
Editor, Senior Moderator
Brief Bioinform
. 2021 May 6;bbab169.
doi: 10.1093/bib/bbab169. Online ahead of print.
The peripheral and core regions of virus-host network of COVID-19
Bingbo Wang[SUP] 1 [/SUP], Xianan Dong[SUP] 1 [/SUP], Jie Hu[SUP] 1 [/SUP], Xiujuan Ma[SUP] 1 [/SUP], Chao Han[SUP] 1 [/SUP], Yajun Wang[SUP] 1 [/SUP], Lin Gao[SUP] 1 [/SUP]
Affiliations
Abstract
Two thousand nineteen novel coronavirus SARS-CoV-2, the pathogen of COVID-19, has caused a catastrophic pandemic, which has a profound and widespread impact on human lives and social economy globally. However, the molecular perturbations induced by the SARS-CoV-2 infection remain unknown. In this paper, from the perspective of omnigenic, we analyze the properties of the neighborhood perturbed by SARS-CoV-2 in the human interactome and disclose the peripheral and core regions of virus-host network (VHN). We find that the virus-host proteins (VHPs) form a significantly connected VHN, among which highly perturbed proteins aggregate into an observable core region. The non-core region of VHN forms a large scale but relatively low perturbed periphery. We further validate that the periphery is non-negligible and conducive to identifying comorbidities and detecting drug repurposing candidates for COVID-19. We particularly put forward a flower model for COVID-19, SARS and H1N1 based on their peripheral regions, and the flower model shows more correlations between COVID-19 and other two similar diseases in common functional pathways and candidate drugs. Overall, our periphery-core pattern can not only offer insights into interconnectivity of SARS-CoV-2 VHPs but also facilitate the research on therapeutic drugs.
Keywords: COVID-19; SARS-CoV-2; disease module; omnigenic; virus-host network.
. 2021 May 6;bbab169.
doi: 10.1093/bib/bbab169. Online ahead of print.
The peripheral and core regions of virus-host network of COVID-19
Bingbo Wang[SUP] 1 [/SUP], Xianan Dong[SUP] 1 [/SUP], Jie Hu[SUP] 1 [/SUP], Xiujuan Ma[SUP] 1 [/SUP], Chao Han[SUP] 1 [/SUP], Yajun Wang[SUP] 1 [/SUP], Lin Gao[SUP] 1 [/SUP]
Affiliations
- PMID: 33956950
- DOI: 10.1093/bib/bbab169
Abstract
Two thousand nineteen novel coronavirus SARS-CoV-2, the pathogen of COVID-19, has caused a catastrophic pandemic, which has a profound and widespread impact on human lives and social economy globally. However, the molecular perturbations induced by the SARS-CoV-2 infection remain unknown. In this paper, from the perspective of omnigenic, we analyze the properties of the neighborhood perturbed by SARS-CoV-2 in the human interactome and disclose the peripheral and core regions of virus-host network (VHN). We find that the virus-host proteins (VHPs) form a significantly connected VHN, among which highly perturbed proteins aggregate into an observable core region. The non-core region of VHN forms a large scale but relatively low perturbed periphery. We further validate that the periphery is non-negligible and conducive to identifying comorbidities and detecting drug repurposing candidates for COVID-19. We particularly put forward a flower model for COVID-19, SARS and H1N1 based on their peripheral regions, and the flower model shows more correlations between COVID-19 and other two similar diseases in common functional pathways and candidate drugs. Overall, our periphery-core pattern can not only offer insights into interconnectivity of SARS-CoV-2 VHPs but also facilitate the research on therapeutic drugs.
Keywords: COVID-19; SARS-CoV-2; disease module; omnigenic; virus-host network.