tetano
Editor, Senior Moderator
Braz J Microbiol
. 2021 Sep 25.
doi: 10.1007/s42770-021-00621-0. Online ahead of print.
Reinfection cases by closely related SARS-CoV-2 lineages in Southern Brazil
Juliana Schons Gularte[SUP] 1 [/SUP], Mariana Soares da Silva[SUP] 2 [/SUP], Meriane Demoliner[SUP] 2 [/SUP], Alana Witt Hansen[SUP] 2 [/SUP], Fágner Henrique Heldt[SUP] 2 [/SUP], Flávio Silveira[SUP] 2 [/SUP], Micheli Filippi[SUP] 2 [/SUP], Vyctoria Malayhka de Abreu Góes Pereira[SUP] 2 [/SUP], Francini Pereira da Silva[SUP] 2 [/SUP], Larissa Mallmann[SUP] 2 [/SUP], Pietra Fink[SUP] 2 [/SUP], Jéssica Luísa Laux[SUP] 2 [/SUP], Matheus Nunes Weber[SUP] 2 [/SUP], Paula Rodrigues de Almeida[SUP] 2 [/SUP], Juliane Deise Fleck[SUP] 2 [/SUP], Fernando Rosado Spilki[SUP] 2 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic that started in late 2019 and still affects people's lives all over the world. Lack of protective immunity after primary infection has been involved with reported reinfection cases by SARS-CoV-2. In this study, we described two cases of reinfection caused by non-VOC (Variants of Concern) strains in southern Brazil, being one patient a healthcare worker. The four samples previously positive for SARS-CoV-2 by real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) were sequenced by a high-performance platform and the genomic analysis confirmed that lineages responsible for infections were B.1.91 and B.1.1.33 (patient 1), and B.1.1.33 and B.1.1.28 (patient 2). The interval between the two positive RT-qPCR for patients 1 and 2 was 45 and 61 days, respectively. This data shows that patients may be reinfected even by very closely related SARS-CoV-2 lineages.
Keywords: B.1; Brazil; COVID-19; Healthcare worker; Reinfection.
. 2021 Sep 25.
doi: 10.1007/s42770-021-00621-0. Online ahead of print.
Reinfection cases by closely related SARS-CoV-2 lineages in Southern Brazil
Juliana Schons Gularte[SUP] 1 [/SUP], Mariana Soares da Silva[SUP] 2 [/SUP], Meriane Demoliner[SUP] 2 [/SUP], Alana Witt Hansen[SUP] 2 [/SUP], Fágner Henrique Heldt[SUP] 2 [/SUP], Flávio Silveira[SUP] 2 [/SUP], Micheli Filippi[SUP] 2 [/SUP], Vyctoria Malayhka de Abreu Góes Pereira[SUP] 2 [/SUP], Francini Pereira da Silva[SUP] 2 [/SUP], Larissa Mallmann[SUP] 2 [/SUP], Pietra Fink[SUP] 2 [/SUP], Jéssica Luísa Laux[SUP] 2 [/SUP], Matheus Nunes Weber[SUP] 2 [/SUP], Paula Rodrigues de Almeida[SUP] 2 [/SUP], Juliane Deise Fleck[SUP] 2 [/SUP], Fernando Rosado Spilki[SUP] 2 [/SUP]
Affiliations
- PMID: 34562232
- DOI: 10.1007/s42770-021-00621-0
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic that started in late 2019 and still affects people's lives all over the world. Lack of protective immunity after primary infection has been involved with reported reinfection cases by SARS-CoV-2. In this study, we described two cases of reinfection caused by non-VOC (Variants of Concern) strains in southern Brazil, being one patient a healthcare worker. The four samples previously positive for SARS-CoV-2 by real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) were sequenced by a high-performance platform and the genomic analysis confirmed that lineages responsible for infections were B.1.91 and B.1.1.33 (patient 1), and B.1.1.33 and B.1.1.28 (patient 2). The interval between the two positive RT-qPCR for patients 1 and 2 was 45 and 61 days, respectively. This data shows that patients may be reinfected even by very closely related SARS-CoV-2 lineages.
Keywords: B.1; Brazil; COVID-19; Healthcare worker; Reinfection.