tetano
Editor, Senior Moderator
Brain and Development
Available online 29 July 2013
High mobility group box 1 in patients with 2009 pandemic H1N1 influenza-associated encephalopathy
Hiroshi Momonakaa,
Shunji Hasegawaa, Corresponding author contact information, E-mail the corresponding author,
Takeshi Matsushigea,
Hirofumi Inouea,
Madoka Kajimotoa,
Seigo Okadaa,
Kenji Nakatsukab,
Tsuneo Morishimac,
Takashi Ichiyamaa
a Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan
b Department of Pediatrics, Toyoura Hospital, Japan
c Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
http://dx.doi.org/10.1016/j.braindev.2013.07.001
Abstract
Background: Patients with 2009 pandemic H1N1 influenza-associated encephalopathy (pIE) have been reported in Japan. The most common clinical symptoms of this condition are seizures and progressive coma with high-grade fever. We previously highlighted the cytokine profile of pIE; our results suggest that proinflammatory cytokines play an important role in the pathogenesis. High mobility group box 1 (HMGB1) protein is a late mediator of inflammation or sepsis. However, there are few reports regarding the serum and cerebrospinal fluid (CSF) levels of HMGB1 in pIE patients. Methods: We measured serum and CSF levels of HMGB1 in the following: pIE patients with poor outcomes, pIE patients without neurological sequelae, influenza patients without pIE, and control subjects. Results: Serum HMGB1 levels were significantly higher in pIE patients with poor outcomes compared to those without neurological sequelae. In contrast, there was no difference in CSF HMGB1 levels among all groups. Regarding pIE patients, we found a significant positive correlation between HMGB1 levels and IL-6 in the serum but not in the CSF. Conclusions: Our results suggest that HMGB1 protein may be involved in the pathogenesis of pIE and that a high serum, but not CSF, level of inflammatory cytokines plays an important role in the severity of pIE.
http://www.sciencedirect.com/science/article/pii/S0387760413002076
Available online 29 July 2013
High mobility group box 1 in patients with 2009 pandemic H1N1 influenza-associated encephalopathy
Hiroshi Momonakaa,
Shunji Hasegawaa, Corresponding author contact information, E-mail the corresponding author,
Takeshi Matsushigea,
Hirofumi Inouea,
Madoka Kajimotoa,
Seigo Okadaa,
Kenji Nakatsukab,
Tsuneo Morishimac,
Takashi Ichiyamaa
a Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan
b Department of Pediatrics, Toyoura Hospital, Japan
c Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
http://dx.doi.org/10.1016/j.braindev.2013.07.001
Abstract
Background: Patients with 2009 pandemic H1N1 influenza-associated encephalopathy (pIE) have been reported in Japan. The most common clinical symptoms of this condition are seizures and progressive coma with high-grade fever. We previously highlighted the cytokine profile of pIE; our results suggest that proinflammatory cytokines play an important role in the pathogenesis. High mobility group box 1 (HMGB1) protein is a late mediator of inflammation or sepsis. However, there are few reports regarding the serum and cerebrospinal fluid (CSF) levels of HMGB1 in pIE patients. Methods: We measured serum and CSF levels of HMGB1 in the following: pIE patients with poor outcomes, pIE patients without neurological sequelae, influenza patients without pIE, and control subjects. Results: Serum HMGB1 levels were significantly higher in pIE patients with poor outcomes compared to those without neurological sequelae. In contrast, there was no difference in CSF HMGB1 levels among all groups. Regarding pIE patients, we found a significant positive correlation between HMGB1 levels and IL-6 in the serum but not in the CSF. Conclusions: Our results suggest that HMGB1 protein may be involved in the pathogenesis of pIE and that a high serum, but not CSF, level of inflammatory cytokines plays an important role in the severity of pIE.
http://www.sciencedirect.com/science/article/pii/S0387760413002076