tetano
Editor, Senior Moderator
Br J Pharmacol
. 2020 May 27.
doi: 10.1111/bph.15143. Online ahead of print.
Animal Models of Mechanisms of SARS-CoV-2 Infection and COVID-19 Pathology
Simon J Cleary[SUP] 1 [/SUP], Simon C Pitchford[SUP] 2 [/SUP], Richard T Amison[SUP] 2 [/SUP], Robert Carrington[SUP] 2 3 [/SUP], C Lorena Robaina Cabrera[SUP] 2 [/SUP], M?lia Magnen[SUP] 1 [/SUP], Mark R Looney[SUP] 1 [/SUP], Elaine Gray[SUP] 2 4 [/SUP], Clive P Page[SUP] 2 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 infections has led to substantial unmet need for treatments, many of which will require testing in appropriate animal models of this disease. Vaccine trials are already underway, but there remains an urgent need to find other therapeutic approaches to either target SARS-CoV-2 or the complications arising from viral infection, particularly the dysregulated immune response and systemic complications which have been associated with progression to severe COVID-19. At the time of writing, in vivo studies of SARS-CoV-2 infection have been described using macaques, cats, ferrets, hamsters, and transgenic mice expressing human angiotensin I converting enzyme 2 (ACE2). These infection models have already been useful for studies of transmission and immunity, but to date only partially model the mechanisms implicated in human severe COVID-19. There is therefore an urgent need for development of animal models for improved evaluation of efficacy of drugs identified as having potential in the treatment of severe COVID-19. These models need to recapitulate key mechanisms of COVID-19 severe acute respiratory distress syndrome and reproduce the immunopathology and systemic sequelae associated with this disease. Here, we review the current models of SARS-CoV-2 infection and COVID-19-related disease mechanisms and suggest ways in which animal models can be adapted to increase their usefulness in research into COVID-19 pathogenesis and for assessing potential treatments.
Keywords: ARDS; Animal models; COVID-19; SARS-CoV-2; coronavirus.
This article is protected by copyright. All rights reserved.
. 2020 May 27.
doi: 10.1111/bph.15143. Online ahead of print.
Animal Models of Mechanisms of SARS-CoV-2 Infection and COVID-19 Pathology
Simon J Cleary[SUP] 1 [/SUP], Simon C Pitchford[SUP] 2 [/SUP], Richard T Amison[SUP] 2 [/SUP], Robert Carrington[SUP] 2 3 [/SUP], C Lorena Robaina Cabrera[SUP] 2 [/SUP], M?lia Magnen[SUP] 1 [/SUP], Mark R Looney[SUP] 1 [/SUP], Elaine Gray[SUP] 2 4 [/SUP], Clive P Page[SUP] 2 [/SUP]
Affiliations
- PMID: 32462701
- DOI: 10.1111/bph.15143
Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 infections has led to substantial unmet need for treatments, many of which will require testing in appropriate animal models of this disease. Vaccine trials are already underway, but there remains an urgent need to find other therapeutic approaches to either target SARS-CoV-2 or the complications arising from viral infection, particularly the dysregulated immune response and systemic complications which have been associated with progression to severe COVID-19. At the time of writing, in vivo studies of SARS-CoV-2 infection have been described using macaques, cats, ferrets, hamsters, and transgenic mice expressing human angiotensin I converting enzyme 2 (ACE2). These infection models have already been useful for studies of transmission and immunity, but to date only partially model the mechanisms implicated in human severe COVID-19. There is therefore an urgent need for development of animal models for improved evaluation of efficacy of drugs identified as having potential in the treatment of severe COVID-19. These models need to recapitulate key mechanisms of COVID-19 severe acute respiratory distress syndrome and reproduce the immunopathology and systemic sequelae associated with this disease. Here, we review the current models of SARS-CoV-2 infection and COVID-19-related disease mechanisms and suggest ways in which animal models can be adapted to increase their usefulness in research into COVID-19 pathogenesis and for assessing potential treatments.
Keywords: ARDS; Animal models; COVID-19; SARS-CoV-2; coronavirus.
This article is protected by copyright. All rights reserved.