tetano
Editor, Senior Moderator
Br J Haematol
. 2020 Jun 17.
doi: 10.1111/bjh.16950. Online ahead of print.
Thrombocytopenia Is Independently Associated With Poor Outcome in Patients Hospitalized for COVID-19
Julien Maquet[SUP] 1 2 [/SUP], Margaux Lafaurie[SUP] 2 3 4 [/SUP], Agn?s Sommet[SUP] 2 3 4 [/SUP], Guillaume Moulis[SUP] 1 2 3 [/SUP], Covid-Clinic-Toul investigators group; Muriel Alvarez, Jacques Amar, Michel Attal, Laurent Balardy, Fr?d?ric Balen, Odile Beyne-Rauzy, Ourdia Bouali, Fanny Bounes, Christophe Bureau, Louis Buscail, Lionel Calviere, Sandrine Charpentier, Fran?ois Chollet, Isabelle Claudet, Arnaud Constantin, Alexa Debard, Karen Delavigne, Pierre Delobel, Julien Delrieu, Alain Didier, Marie Faruch, Olivier Fourcade, Bernard Georges, Etienne Grunenwald, Sophie Guyonnet, H?l?ne Hanaire, Christophe Hein, Nassim Kamar, Olivier Lairez, Pierre Mansat, Guillaume Martin-Blondel, Vincent Minville, J?r?mie Pariente, Carle Paul, Pierre Payoux, Gr?gory Pugnet, Marie-L?a Piel-Julian, Christian Recher, Yves Rolland, Adeline Ruyssen-Witrand, Jean Sabatier, Laurent Sailler, Jean-Pierre Salles, Nicolas Sans, Marion Secher, Annick Sevely, Stein Silva, Claire Thalamas, Olivier Toulza
Affiliations
Abstract
Thrombocytopenia (defined by platelet count <150 x 10[SUP]9[/SUP] /L) has been observed in up to 36% of patients with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for Coronavirus disease 2019 (COVID-19; Guan et al, 2020). In this setting, thrombocytopenia is usually mild, caused by platelet activation and consumption (Thachil, 2020; Pavord et al, 2020). In a recent paper published in the British Journal of Haematology, Jiang et al. conducted a meta-analysis of 31 studies involving 7613 participants and found a significant association between thrombocytopenia and severe COVID-19 hospitalized patients or poor outcome in this setting (Jiang et al, 2020). However, other clinical, biological and radiological factors strongly impact COVID-19 outcome. Whether thrombocytopenia is independently associated to poor outcome in this population is unknown. This study was aimed at addressing this question.
Keywords: COVID-2019; SARS-CoV-2; intensive care unit; mortality; thrombocytopenia.
. 2020 Jun 17.
doi: 10.1111/bjh.16950. Online ahead of print.
Thrombocytopenia Is Independently Associated With Poor Outcome in Patients Hospitalized for COVID-19
Julien Maquet[SUP] 1 2 [/SUP], Margaux Lafaurie[SUP] 2 3 4 [/SUP], Agn?s Sommet[SUP] 2 3 4 [/SUP], Guillaume Moulis[SUP] 1 2 3 [/SUP], Covid-Clinic-Toul investigators group; Muriel Alvarez, Jacques Amar, Michel Attal, Laurent Balardy, Fr?d?ric Balen, Odile Beyne-Rauzy, Ourdia Bouali, Fanny Bounes, Christophe Bureau, Louis Buscail, Lionel Calviere, Sandrine Charpentier, Fran?ois Chollet, Isabelle Claudet, Arnaud Constantin, Alexa Debard, Karen Delavigne, Pierre Delobel, Julien Delrieu, Alain Didier, Marie Faruch, Olivier Fourcade, Bernard Georges, Etienne Grunenwald, Sophie Guyonnet, H?l?ne Hanaire, Christophe Hein, Nassim Kamar, Olivier Lairez, Pierre Mansat, Guillaume Martin-Blondel, Vincent Minville, J?r?mie Pariente, Carle Paul, Pierre Payoux, Gr?gory Pugnet, Marie-L?a Piel-Julian, Christian Recher, Yves Rolland, Adeline Ruyssen-Witrand, Jean Sabatier, Laurent Sailler, Jean-Pierre Salles, Nicolas Sans, Marion Secher, Annick Sevely, Stein Silva, Claire Thalamas, Olivier Toulza
Affiliations
- PMID: 32557535
- DOI: 10.1111/bjh.16950
Abstract
Thrombocytopenia (defined by platelet count <150 x 10[SUP]9[/SUP] /L) has been observed in up to 36% of patients with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for Coronavirus disease 2019 (COVID-19; Guan et al, 2020). In this setting, thrombocytopenia is usually mild, caused by platelet activation and consumption (Thachil, 2020; Pavord et al, 2020). In a recent paper published in the British Journal of Haematology, Jiang et al. conducted a meta-analysis of 31 studies involving 7613 participants and found a significant association between thrombocytopenia and severe COVID-19 hospitalized patients or poor outcome in this setting (Jiang et al, 2020). However, other clinical, biological and radiological factors strongly impact COVID-19 outcome. Whether thrombocytopenia is independently associated to poor outcome in this population is unknown. This study was aimed at addressing this question.
Keywords: COVID-2019; SARS-CoV-2; intensive care unit; mortality; thrombocytopenia.