tetano
Editor, Senior Moderator
Br J Haematol
. 2023 Oct 11.
doi: 10.1111/bjh.19125. Online ahead of print. Prolonged platelet hyperactivity after COVID-19 infection
Noriko Nara[SUP] 1 [/SUP], Mie Shimizu[SUP] 1 [/SUP], Masahiro Yamamoto[SUP] 1 [/SUP], Tomoki Nakamizo[SUP] 2 [/SUP], Azusa Hayakawa[SUP] 3 [/SUP], Ken Johkura[SUP] 1 [/SUP]
Affiliations
Platelet hyperactivity often occurs in patients with coronavirus disease 2019 (COVID-19). However, it remains unclear how long platelet hyperactivity lasts after the acute phase, owing to a lack of follow-up studies. To elucidate the course of platelet hyperactivity, we serially measured platelet activity in patients with COVID-19 up to 40 days after hospital admission using an easily assessable haematology analyser that semi-quantitates platelet clumps on a scattergram. Our results showed that platelet hyperactivity persisted for at least 40 days even after acute inflammation subsided in most patients with COVID-19, regardless of disease severity. Persistent platelet hyperactivity may contribute to thromboembolic complications in post-COVID-19 patients.
Keywords: COVID-19; haematology analyser; long COVID-19; platelet clumps; platelet hyperactivity.
. 2023 Oct 11.
doi: 10.1111/bjh.19125. Online ahead of print. Prolonged platelet hyperactivity after COVID-19 infection
Noriko Nara[SUP] 1 [/SUP], Mie Shimizu[SUP] 1 [/SUP], Masahiro Yamamoto[SUP] 1 [/SUP], Tomoki Nakamizo[SUP] 2 [/SUP], Azusa Hayakawa[SUP] 3 [/SUP], Ken Johkura[SUP] 1 [/SUP]
Affiliations
- PMID: 37822090
- DOI: 10.1111/bjh.19125
Platelet hyperactivity often occurs in patients with coronavirus disease 2019 (COVID-19). However, it remains unclear how long platelet hyperactivity lasts after the acute phase, owing to a lack of follow-up studies. To elucidate the course of platelet hyperactivity, we serially measured platelet activity in patients with COVID-19 up to 40 days after hospital admission using an easily assessable haematology analyser that semi-quantitates platelet clumps on a scattergram. Our results showed that platelet hyperactivity persisted for at least 40 days even after acute inflammation subsided in most patients with COVID-19, regardless of disease severity. Persistent platelet hyperactivity may contribute to thromboembolic complications in post-COVID-19 patients.
Keywords: COVID-19; haematology analyser; long COVID-19; platelet clumps; platelet hyperactivity.