tetano
Editor, Senior Moderator
BMJ Open Respir Res
. 2025 Feb 10;12(1):e001985.
doi: 10.1136/bmjresp-2023-001985. Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients
Robert Sykes[SUP] 1 2 [/SUP], Andrew J Morrow[SUP] 1 2 [/SUP], Kenneth Mangion[SUP] 1 3 [/SUP], Alex McConnachie[SUP] 4 [/SUP], Alasdair McIntosh[SUP] 1 [/SUP], Giles Roditi[SUP] 5 [/SUP], Liam Peng[SUP] 6 [/SUP], Claire Rooney[SUP] 7 [/SUP], Kathryn Scott[SUP] 8 [/SUP], David Barrie Stobo[SUP] 6 [/SUP], Colin Berry[SUP] 9 [/SUP], Colin Church[SUP] 10 [/SUP], Hannah Bayes[SUP] 11 [/SUP]; CISCO-19 investigators
Collaborators, Affiliations
Background: The radiological trajectory of post-COVID-19 is uncertain. We present a prospective, observational, multicentre cohort study using multimodality imaging to describe the pulmonary sequelae of patients hospitalised with COVID-19, predictors of persistent abnormal radiology and implications on health status.
Methods: In survivors of COVID-19, we performed convalescent CT pulmonary angiogram and high-resolution CT imaging as part of the CISCO-19 study (ClinicalTrials.gov ID NCT04403607). This included serial blood biomarkers and patient-reported outcomes 28-60 days following discharge from hospital.
Results: Of the COVID-19 cohort, 88 (56%) patients of the COVID-19 cohort (n = 159; mean age, 55 years; 43% female) had persisting radiological abnormalities at 28-60 days postdischarge. This included ground-glass opacification (45%), reticulation/architectural distortion (30%) or mixed pattern (19%). These features were very infrequent among a group of age-matched, sex-matched and cardiovascular risk factor-matched controls (n=29). The majority of COVID-19 cohort (68%) had less than 20% persisting radiological abnormalities, with 67% demonstrating overall improvement compared with admission imaging. Older age, premorbid performance status, typical acute COVID-19 radiological features, markers of severe acute COVID-19, convalescent ICAM-1 and P-selectin were associated with persisting lung abnormalities (all p<0.05). Patients with persisting abnormalities were shown to have lower levels of physical activity and predicted maximal oxygen utilisation (derived VO[SUB]2[/SUB]) (both p<0.05). Higher percentage of abnormal lung parenchyma was associated with lower patient-assessed quality of life (EQ-5D-5L) score (p=0.03).
Conclusions: Persistent radiological abnormalities post-COVID-19 were common at 28-60 days postdischarge from hospital, although most improved. Patients with persisting radiological abnormalities 28-60 days postdischarge are at risk of persisting health impairment in the longer term and represent a population for targeted intervention.
Trial registration number: NCT04403607.
Keywords: COVID-19; Imaging/CT MRI etc; Respiratory Infection.
. 2025 Feb 10;12(1):e001985.
doi: 10.1136/bmjresp-2023-001985. Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients
Robert Sykes[SUP] 1 2 [/SUP], Andrew J Morrow[SUP] 1 2 [/SUP], Kenneth Mangion[SUP] 1 3 [/SUP], Alex McConnachie[SUP] 4 [/SUP], Alasdair McIntosh[SUP] 1 [/SUP], Giles Roditi[SUP] 5 [/SUP], Liam Peng[SUP] 6 [/SUP], Claire Rooney[SUP] 7 [/SUP], Kathryn Scott[SUP] 8 [/SUP], David Barrie Stobo[SUP] 6 [/SUP], Colin Berry[SUP] 9 [/SUP], Colin Church[SUP] 10 [/SUP], Hannah Bayes[SUP] 11 [/SUP]; CISCO-19 investigators
Collaborators, Affiliations
- PMID: 39929549
- DOI: 10.1136/bmjresp-2023-001985
Background: The radiological trajectory of post-COVID-19 is uncertain. We present a prospective, observational, multicentre cohort study using multimodality imaging to describe the pulmonary sequelae of patients hospitalised with COVID-19, predictors of persistent abnormal radiology and implications on health status.
Methods: In survivors of COVID-19, we performed convalescent CT pulmonary angiogram and high-resolution CT imaging as part of the CISCO-19 study (ClinicalTrials.gov ID NCT04403607). This included serial blood biomarkers and patient-reported outcomes 28-60 days following discharge from hospital.
Results: Of the COVID-19 cohort, 88 (56%) patients of the COVID-19 cohort (n = 159; mean age, 55 years; 43% female) had persisting radiological abnormalities at 28-60 days postdischarge. This included ground-glass opacification (45%), reticulation/architectural distortion (30%) or mixed pattern (19%). These features were very infrequent among a group of age-matched, sex-matched and cardiovascular risk factor-matched controls (n=29). The majority of COVID-19 cohort (68%) had less than 20% persisting radiological abnormalities, with 67% demonstrating overall improvement compared with admission imaging. Older age, premorbid performance status, typical acute COVID-19 radiological features, markers of severe acute COVID-19, convalescent ICAM-1 and P-selectin were associated with persisting lung abnormalities (all p<0.05). Patients with persisting abnormalities were shown to have lower levels of physical activity and predicted maximal oxygen utilisation (derived VO[SUB]2[/SUB]) (both p<0.05). Higher percentage of abnormal lung parenchyma was associated with lower patient-assessed quality of life (EQ-5D-5L) score (p=0.03).
Conclusions: Persistent radiological abnormalities post-COVID-19 were common at 28-60 days postdischarge from hospital, although most improved. Patients with persisting radiological abnormalities 28-60 days postdischarge are at risk of persisting health impairment in the longer term and represent a population for targeted intervention.
Trial registration number: NCT04403607.
Keywords: COVID-19; Imaging/CT MRI etc; Respiratory Infection.