tetano
Editor, Senior Moderator
BMJ Open
. 2024 Jun 6;14(6):e080393.
doi: 10.1136/bmjopen-2023-080393. COVID-19 profiles in general practice: a latent class analysis
Emilie Ferrat[SUP] 1 2 3 [/SUP], William Mirat[SUP] 4 5 [/SUP], Emmanuelle Boutin[SUP] 1 6 [/SUP], Emilie Maroto[SUP] 2 [/SUP], Sophie Brossier[SUP] 2 7 [/SUP], Jean-Denis Hoonakker[SUP] 2 8 [/SUP], Etienne Audureau[SUP] 1 6 9 [/SUP], Tan-Trung Phan[SUP] 2 7 [/SUP], Sylvie Bastuji-Garin[SUP] 1 9 [/SUP]
Affiliations
Background: General practitioners (GPs) were on the front line of the COVID-19 outbreak. Identifying clinical profiles in COVID-19 might improve patient care and enable closer monitoring of at-risk profiles.
Objectives: To identify COVID-19 profiles in a population of adult primary care patients, and to determine whether the profiles were associated with negative outcomes and persistent symptoms.
Design, setting and participants: In a prospective multicentre study, 44 GPs from multiprofessional primary care practices in the Paris area of France recruited 340 consecutive adult patients (median age: 47 years) with a confirmed diagnosis of COVID-19 during the first two waves of the epidemic.
Method and outcome: A latent class (LC) analysis with 11 indicators (clinical signs and symptoms) was performed. The resulting profiles were characterised by a 3-month composite outcome (COVID-19-related hospital admission and/or death) and persistent symptoms three and 6 months after inclusion.
Results: We identified six profiles: 'paucisymptomatic' (LC1, 9%), 'anosmia and/or ageusia' (LC2, 12.9%), 'influenza-like syndrome with anosmia and ageusia' (LC3, 15.5%), 'influenza-like syndrome without anosmia or ageusia' (LC4, 24.5%), 'influenza-like syndrome with respiratory impairment' (LC5) and a 'complete form' (LC6, 17.7%). At 3 months, 7.4% of the patients were hospitalised (with higher rates in LC5), and 18% had persistent symptoms (with higher rates in LC5 and LC6). At 6 months, 6.4% of the patients had persistent symptoms, with no differences between LCs.
Conclusion: Our findings might help GPs to identify patients at risk of persistent COVID-19 symptoms and hospital admission and then set up procedures for closer monitoring.
Keywords: COVID-19; SARS-CoV-2 infection; clinical decision-making; primary health care.
. 2024 Jun 6;14(6):e080393.
doi: 10.1136/bmjopen-2023-080393. COVID-19 profiles in general practice: a latent class analysis
Emilie Ferrat[SUP] 1 2 3 [/SUP], William Mirat[SUP] 4 5 [/SUP], Emmanuelle Boutin[SUP] 1 6 [/SUP], Emilie Maroto[SUP] 2 [/SUP], Sophie Brossier[SUP] 2 7 [/SUP], Jean-Denis Hoonakker[SUP] 2 8 [/SUP], Etienne Audureau[SUP] 1 6 9 [/SUP], Tan-Trung Phan[SUP] 2 7 [/SUP], Sylvie Bastuji-Garin[SUP] 1 9 [/SUP]
Affiliations
- PMID: 38844390
- DOI: 10.1136/bmjopen-2023-080393
Background: General practitioners (GPs) were on the front line of the COVID-19 outbreak. Identifying clinical profiles in COVID-19 might improve patient care and enable closer monitoring of at-risk profiles.
Objectives: To identify COVID-19 profiles in a population of adult primary care patients, and to determine whether the profiles were associated with negative outcomes and persistent symptoms.
Design, setting and participants: In a prospective multicentre study, 44 GPs from multiprofessional primary care practices in the Paris area of France recruited 340 consecutive adult patients (median age: 47 years) with a confirmed diagnosis of COVID-19 during the first two waves of the epidemic.
Method and outcome: A latent class (LC) analysis with 11 indicators (clinical signs and symptoms) was performed. The resulting profiles were characterised by a 3-month composite outcome (COVID-19-related hospital admission and/or death) and persistent symptoms three and 6 months after inclusion.
Results: We identified six profiles: 'paucisymptomatic' (LC1, 9%), 'anosmia and/or ageusia' (LC2, 12.9%), 'influenza-like syndrome with anosmia and ageusia' (LC3, 15.5%), 'influenza-like syndrome without anosmia or ageusia' (LC4, 24.5%), 'influenza-like syndrome with respiratory impairment' (LC5) and a 'complete form' (LC6, 17.7%). At 3 months, 7.4% of the patients were hospitalised (with higher rates in LC5), and 18% had persistent symptoms (with higher rates in LC5 and LC6). At 6 months, 6.4% of the patients had persistent symptoms, with no differences between LCs.
Conclusion: Our findings might help GPs to identify patients at risk of persistent COVID-19 symptoms and hospital admission and then set up procedures for closer monitoring.
Keywords: COVID-19; SARS-CoV-2 infection; clinical decision-making; primary health care.