tetano
Editor, Senior Moderator
BMJ Case Rep
. 2020 Sep 14;13(9):e235636.
doi: 10.1136/bcr-2020-235636.
Neuro-ophthalmological consequences of acute influenza A encephalitis in a genetically predisposed child
Catarina Xavier[SUP] 1 [/SUP], Miguel Boncquet Vieira[SUP] 1 [/SUP], Cristina Ferreira[SUP] 1 2 3 [/SUP], Joana Tavares Ferreira[SUP] 4 3 5 [/SUP]
Affiliations
Abstract
Acute necrotising encephalopathy (ANE) is a rare disease that corresponds to a rapidly progressive encephalopathy induced by a viral infection. It is frequently associated with a mutation on the RAN-binding protein 2 (RANBP2) gene-ANE1. We present a case of a 5-year-old boy with a clinical picture of influenza aggravated to an acute encephalopathy picture after the 3rd day. Complementary examinations came back positive for the influenza A virus, and MRI showed aspects compatible with ANE. He was treated accordingly with subsequent improvement of the clinical picture. During ambulatory follow-up, a mutation was detected on the RANBP2 gene and, at the ophthalmological level, bilateral peripheral constriction on the campimetry and a significant reduction of bilateral peripapillary retinal nerve fibre layer was reported. Our case contributes to the enrichment of the neuro-ophthalmological literature and expands the spectrum of sequelae of this rare entity in the Caucasian population.
Keywords: infection (neurology); neuroopthalmology; visual pathway.
. 2020 Sep 14;13(9):e235636.
doi: 10.1136/bcr-2020-235636.
Neuro-ophthalmological consequences of acute influenza A encephalitis in a genetically predisposed child
Catarina Xavier[SUP] 1 [/SUP], Miguel Boncquet Vieira[SUP] 1 [/SUP], Cristina Ferreira[SUP] 1 2 3 [/SUP], Joana Tavares Ferreira[SUP] 4 3 5 [/SUP]
Affiliations
- PMID: 32928829
- DOI: 10.1136/bcr-2020-235636
Abstract
Acute necrotising encephalopathy (ANE) is a rare disease that corresponds to a rapidly progressive encephalopathy induced by a viral infection. It is frequently associated with a mutation on the RAN-binding protein 2 (RANBP2) gene-ANE1. We present a case of a 5-year-old boy with a clinical picture of influenza aggravated to an acute encephalopathy picture after the 3rd day. Complementary examinations came back positive for the influenza A virus, and MRI showed aspects compatible with ANE. He was treated accordingly with subsequent improvement of the clinical picture. During ambulatory follow-up, a mutation was detected on the RANBP2 gene and, at the ophthalmological level, bilateral peripheral constriction on the campimetry and a significant reduction of bilateral peripapillary retinal nerve fibre layer was reported. Our case contributes to the enrichment of the neuro-ophthalmological literature and expands the spectrum of sequelae of this rare entity in the Caucasian population.
Keywords: infection (neurology); neuroopthalmology; visual pathway.