tetano
Editor, Senior Moderator
BMC Res Notes
. 2021 Oct 29;14(1):401.
doi: 10.1186/s13104-021-05816-0.
Dysregulation of RNA interference components in COVID-19 patients
Seyyed Reza Mousavi[SUP] 1 2 [/SUP], Maryam Sadat Sajjadi[SUP] 3 [/SUP], Farinaz Khosravian[SUP] 1 2 [/SUP], Sara Feizbakhshan[SUP] 1 2 [/SUP], Sharareh Salmanizadeh[SUP] 1 2 [/SUP], Zahra Taherian Esfahani[SUP] 3 [/SUP], Faeze Ahmadi Beni[SUP] 1 2 4 [/SUP], Ameneh Arab[SUP] 5 [/SUP], Mohammad Kazemi[SUP] 4 [/SUP], Kiana Shahzamani[SUP] 6 [/SUP], Ramin Sami[SUP] 7 [/SUP], Majid Hosseinzadeh[SUP] 8 [/SUP], Mansoor Salehi[SUP] 9 10 11 [/SUP], Hajie Lotfi[SUP] 12 [/SUP]
Affiliations
Abstract
Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus causing severe respiratory illness (COVID-19). This virus was initially identified in Wuhan city, a populated area of the Hubei province in China, and still remains one of the major global health challenges. RNA interference (RNAi) is a mechanism of post-transcriptional gene silencing that plays a crucial role in innate viral defense mechanisms by inhibiting the virus replication as well as expression of various viral proteins. Dicer, Drosha, Ago2, and DGCR8 are essential components of the RNAi system, which is supposed to be dysregulated in COVID-19 patients. This study aimed to assess the expression level of the mentioned mRNAs in COVID-19patients compared to healthy individuals.
Results: Our findings demonstrated that the expression of Dicer, Drosha, and Ago2 was statistically altered in COVID-19 patients compared to healthy subjects. Ultimately, the RNA interference mechanism as a crucial antiviral defense system was suggested to be dysregulated in COVID-19 patients.
Keywords: Ago2; DGCR8; Dicer; Drosha; RNA interference; SARS-CoV-2.
. 2021 Oct 29;14(1):401.
doi: 10.1186/s13104-021-05816-0.
Dysregulation of RNA interference components in COVID-19 patients
Seyyed Reza Mousavi[SUP] 1 2 [/SUP], Maryam Sadat Sajjadi[SUP] 3 [/SUP], Farinaz Khosravian[SUP] 1 2 [/SUP], Sara Feizbakhshan[SUP] 1 2 [/SUP], Sharareh Salmanizadeh[SUP] 1 2 [/SUP], Zahra Taherian Esfahani[SUP] 3 [/SUP], Faeze Ahmadi Beni[SUP] 1 2 4 [/SUP], Ameneh Arab[SUP] 5 [/SUP], Mohammad Kazemi[SUP] 4 [/SUP], Kiana Shahzamani[SUP] 6 [/SUP], Ramin Sami[SUP] 7 [/SUP], Majid Hosseinzadeh[SUP] 8 [/SUP], Mansoor Salehi[SUP] 9 10 11 [/SUP], Hajie Lotfi[SUP] 12 [/SUP]
Affiliations
- PMID: 34715923
- DOI: 10.1186/s13104-021-05816-0
Abstract
Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus causing severe respiratory illness (COVID-19). This virus was initially identified in Wuhan city, a populated area of the Hubei province in China, and still remains one of the major global health challenges. RNA interference (RNAi) is a mechanism of post-transcriptional gene silencing that plays a crucial role in innate viral defense mechanisms by inhibiting the virus replication as well as expression of various viral proteins. Dicer, Drosha, Ago2, and DGCR8 are essential components of the RNAi system, which is supposed to be dysregulated in COVID-19 patients. This study aimed to assess the expression level of the mentioned mRNAs in COVID-19patients compared to healthy individuals.
Results: Our findings demonstrated that the expression of Dicer, Drosha, and Ago2 was statistically altered in COVID-19 patients compared to healthy subjects. Ultimately, the RNA interference mechanism as a crucial antiviral defense system was suggested to be dysregulated in COVID-19 patients.
Keywords: Ago2; DGCR8; Dicer; Drosha; RNA interference; SARS-CoV-2.