tetano
Editor, Senior Moderator
BMC Pulm Med
. 2020 Nov 23;20(1):308.
doi: 10.1186/s12890-020-01348-8.
Recurrence of SARS-CoV-2 nucleic acid positive test in patients with COVID-19: a report of two cases
Jian Wu[SUP] 1 2 [/SUP], Juan Cheng[SUP] 3 [/SUP], Xiaowei Shi[SUP] 1 [/SUP], Jun Liu[SUP] 4 [/SUP], Biao Huang[SUP] 5 [/SUP], Xinguo Zhao[SUP] 6 [/SUP], Yuanwang Qiu[SUP] 7 [/SUP], Jiong Yu[SUP] 1 [/SUP], Hongcui Cao[SUP] 8 9 [/SUP], Lanjuan Li[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The recurrence of positive SARS-CoV-2 nucleic acid test results in patients with COVID-19 is becoming more important and warrants more attention.
Case presentation: This study reports 2 cases, a child with mild COVID-19 and an adult female with moderate COVID-19, who were discharged after three consecutive negative nucleic acid tests and were later readmitted to the hospital for recurrence of SARS-CoV-2 nucleic acid positivity. By tracking the patients' symptoms, serum antibodies, and imaging manifestations after readmission, we found that they showed a trend of gradual improvement and recovery throughout treatment. They were cured without additional treatment, with the appearance of antibodies and the recovery of immune functions.
Conclusions: It is deemed extremely necessary to improve the discharge standard of care. At the same time, nucleic acid detection is recommended to increase the dynamic monitoring of serum antibodies and imaging, strengthen the management of discharged patients, and appropriately extend the home or centralized isolation time.
Keywords: Coronavirus disease-19 (COVID-19); Nucleic acid test; Recurrence; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2020 Nov 23;20(1):308.
doi: 10.1186/s12890-020-01348-8.
Recurrence of SARS-CoV-2 nucleic acid positive test in patients with COVID-19: a report of two cases
Jian Wu[SUP] 1 2 [/SUP], Juan Cheng[SUP] 3 [/SUP], Xiaowei Shi[SUP] 1 [/SUP], Jun Liu[SUP] 4 [/SUP], Biao Huang[SUP] 5 [/SUP], Xinguo Zhao[SUP] 6 [/SUP], Yuanwang Qiu[SUP] 7 [/SUP], Jiong Yu[SUP] 1 [/SUP], Hongcui Cao[SUP] 8 9 [/SUP], Lanjuan Li[SUP] 1 [/SUP]
Affiliations
- PMID: 33225932
- DOI: 10.1186/s12890-020-01348-8
Abstract
Background: The recurrence of positive SARS-CoV-2 nucleic acid test results in patients with COVID-19 is becoming more important and warrants more attention.
Case presentation: This study reports 2 cases, a child with mild COVID-19 and an adult female with moderate COVID-19, who were discharged after three consecutive negative nucleic acid tests and were later readmitted to the hospital for recurrence of SARS-CoV-2 nucleic acid positivity. By tracking the patients' symptoms, serum antibodies, and imaging manifestations after readmission, we found that they showed a trend of gradual improvement and recovery throughout treatment. They were cured without additional treatment, with the appearance of antibodies and the recovery of immune functions.
Conclusions: It is deemed extremely necessary to improve the discharge standard of care. At the same time, nucleic acid detection is recommended to increase the dynamic monitoring of serum antibodies and imaging, strengthen the management of discharged patients, and appropriately extend the home or centralized isolation time.
Keywords: Coronavirus disease-19 (COVID-19); Nucleic acid test; Recurrence; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).