tetano
Editor, Senior Moderator
BMC Psychiatry
. 2025 Apr 8;25(1):351.
doi: 10.1186/s12888-025-06789-1. Case report: post COVID-19 encephalopathy and oral cenesthopathy
Ju-I Wu[SUP] 1 [/SUP], Shwu-Hua Lee[SUP] 1 2 [/SUP], Pei-Jung Chen[SUP] 3 4 [/SUP]
Affiliations
Post-COVID-19 encephalopathy is a neurological complication characterized by cognitive impairment, memory loss, and other neuropsychiatric symptoms in COVID-19 survivors. Oral cenesthopathy, a rare somatic delusion characterized by unusual oral sensations without physical findings, is typically associated with affective disorders and schizophrenia. This case report describes a 73-year-old female who developed post-COVID-19 encephalopathy, presenting initially with cognitive decline, followed by major depression and oral cenesthopathy 16 months after the infection. Comprehensive investigations excluded autoimmune encephalitis, Creutzfeldt-Jakob disease, and other structural or vascular abnormalities. Treatment with Aripiprazole and Carbamazepine resulted in partial improvement, though symptom control was limited by medication side effects. This case represents a rare presentation of long COVID syndrome, highlighting the complex neuropsychiatric sequelae of COVID-19. Further research is needed to explore the pathophysiology, treatment strategies, and long-term impacts of such manifestations.
Keywords: Case report; Delusional disorder somatic type; Long COVID syndrome; Oral cenesthopathy; Post COVID-19 encephalopathy.
. 2025 Apr 8;25(1):351.
doi: 10.1186/s12888-025-06789-1. Case report: post COVID-19 encephalopathy and oral cenesthopathy
Ju-I Wu[SUP] 1 [/SUP], Shwu-Hua Lee[SUP] 1 2 [/SUP], Pei-Jung Chen[SUP] 3 4 [/SUP]
Affiliations
- PMID: 40200197
- PMCID: PMC11980331
- DOI: 10.1186/s12888-025-06789-1
Post-COVID-19 encephalopathy is a neurological complication characterized by cognitive impairment, memory loss, and other neuropsychiatric symptoms in COVID-19 survivors. Oral cenesthopathy, a rare somatic delusion characterized by unusual oral sensations without physical findings, is typically associated with affective disorders and schizophrenia. This case report describes a 73-year-old female who developed post-COVID-19 encephalopathy, presenting initially with cognitive decline, followed by major depression and oral cenesthopathy 16 months after the infection. Comprehensive investigations excluded autoimmune encephalitis, Creutzfeldt-Jakob disease, and other structural or vascular abnormalities. Treatment with Aripiprazole and Carbamazepine resulted in partial improvement, though symptom control was limited by medication side effects. This case represents a rare presentation of long COVID syndrome, highlighting the complex neuropsychiatric sequelae of COVID-19. Further research is needed to explore the pathophysiology, treatment strategies, and long-term impacts of such manifestations.
Keywords: Case report; Delusional disorder somatic type; Long COVID syndrome; Oral cenesthopathy; Post COVID-19 encephalopathy.