tetano
Editor, Senior Moderator
BMC Nephrol
. 2025 Jun 23;26(1):290.
doi: 10.1186/s12882-025-04264-3. Chronic heart failure and hypoalbuminemia are risk factors of poorer mRNA SARS-CoV-2 vaccine response in maintenance Hemodialysis patients (the COVaccinDia study)
Pierre Laurent[SUP] 1 [/SUP], Marianne Renou[SUP] 1 [/SUP], Najeh El Esper[SUP] 1 [/SUP], Gabriel Choukroun[SUP] 1 2 [/SUP], Pierre Pommerolle[SUP] 1 [/SUP], Sébastien Laburthe[SUP] 3 [/SUP], Pauline Caillard[SUP] 4 5 [/SUP]
Affiliations
Background: Chronic kidney disease represents an immunocompromising condition and a cause of a lower vaccine efficacy, even in patients undergoing maintenance dialysis. Recent SARS-CoV-2 outbreaks have prompted clinicians to better understand the underlying mechanisms and establish more suitable vaccination schedules.
Methods: In a single-center, retrospective, observational study of patients undergoing maintenance dialysis in France, we studied the factors associated with the intensity of the humoral response to a SARS-CoV-2 vaccine in this population, including specific dialysis-related variables.
Results: After having received three doses of SARS-CoV-2 mRNA vaccine, a cohort of 80 patients was divided into low-responders (28 patients with an anti-SARS-CoV-2 antibody level of 50-1830 AU/mL) and responders (52 patients with an antibody level > 1830 AU/mL). We found that chronic heart failure (p < 0.00001), higher performance status (p = 0.004), hypoalbuminemia (p < 0.001), lymphopenia (p = 0.003), Rhesus status positivity (p = 0.02), and absence of response to a hepatitis B virus vaccine (p = 0.02) were associated with a poor response to a third dose of SARS-CoV-2 vaccine. In contrast, none of the dialysis-related variables were associated with the vaccine response. In multivariate logistic regression, chronic heart failure (p < 0.0001) and hypoalbuminemia (p = 0.0004) remained associated with a lower humoral response to SARS-CoV-2 vaccine.
Conclusions: Our results showed that chronic heart failure and hypoalbuminemia were factors associated with a poor humoral response after three doses of SARS-CoV-2 vaccine. However, we found no association between specific dialysis-related variables and the anti-SARS-CoV-2 antibody titer.
Keywords: COVID-19; Hemodialysis; Humoral response; SARS-CoV-2; Vaccines.
. 2025 Jun 23;26(1):290.
doi: 10.1186/s12882-025-04264-3. Chronic heart failure and hypoalbuminemia are risk factors of poorer mRNA SARS-CoV-2 vaccine response in maintenance Hemodialysis patients (the COVaccinDia study)
Pierre Laurent[SUP] 1 [/SUP], Marianne Renou[SUP] 1 [/SUP], Najeh El Esper[SUP] 1 [/SUP], Gabriel Choukroun[SUP] 1 2 [/SUP], Pierre Pommerolle[SUP] 1 [/SUP], Sébastien Laburthe[SUP] 3 [/SUP], Pauline Caillard[SUP] 4 5 [/SUP]
Affiliations
- PMID: 40551111
- PMCID: PMC12186387
- DOI: 10.1186/s12882-025-04264-3
Background: Chronic kidney disease represents an immunocompromising condition and a cause of a lower vaccine efficacy, even in patients undergoing maintenance dialysis. Recent SARS-CoV-2 outbreaks have prompted clinicians to better understand the underlying mechanisms and establish more suitable vaccination schedules.
Methods: In a single-center, retrospective, observational study of patients undergoing maintenance dialysis in France, we studied the factors associated with the intensity of the humoral response to a SARS-CoV-2 vaccine in this population, including specific dialysis-related variables.
Results: After having received three doses of SARS-CoV-2 mRNA vaccine, a cohort of 80 patients was divided into low-responders (28 patients with an anti-SARS-CoV-2 antibody level of 50-1830 AU/mL) and responders (52 patients with an antibody level > 1830 AU/mL). We found that chronic heart failure (p < 0.00001), higher performance status (p = 0.004), hypoalbuminemia (p < 0.001), lymphopenia (p = 0.003), Rhesus status positivity (p = 0.02), and absence of response to a hepatitis B virus vaccine (p = 0.02) were associated with a poor response to a third dose of SARS-CoV-2 vaccine. In contrast, none of the dialysis-related variables were associated with the vaccine response. In multivariate logistic regression, chronic heart failure (p < 0.0001) and hypoalbuminemia (p = 0.0004) remained associated with a lower humoral response to SARS-CoV-2 vaccine.
Conclusions: Our results showed that chronic heart failure and hypoalbuminemia were factors associated with a poor humoral response after three doses of SARS-CoV-2 vaccine. However, we found no association between specific dialysis-related variables and the anti-SARS-CoV-2 antibody titer.
Keywords: COVID-19; Hemodialysis; Humoral response; SARS-CoV-2; Vaccines.