Snowy Owl
Retired in 2010, In Memoriam
The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
BMC Infectious Diseases 2006, 6:82 doi:10.1186/1471-2334-6-82
<table class="smalltext" cellpadding="0" cellspacing="0"><tbody><tr> <td>Published</td> <td width="25">
</td> <td>4 May 2006</td> </tr> </tbody></table>
Abstract (provisional)
Background
Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma, TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).
Methods
A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma, TNF-alpha and IL-10 for their associations with SARS.
Results
IFN-gamma +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P<0.001). Individuals with IFN-gamma +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-alpha were not associated with SARS susceptibility.
Conclusions
IFN-gamma +874A allele was shown to be a risk factor in SARS susceptibility.
http://www.biomedcentral.com/1471-2334/6/82/abstract
Wai Po Chong, WK Eddie Ip, Gloria Hoi Wan Tso, Man Wai Ng, Wilfred Hing Sang Wong, Helen Ka Wai Law, Raymond WH Yung, Eudora Y Chow, Kl Au, Eric YT Chan, Wilina Lim, JS Malik Peiris and Yu Lung Lau
BMC Infectious Diseases 2006, 6:82 doi:10.1186/1471-2334-6-82
<table class="smalltext" cellpadding="0" cellspacing="0"><tbody><tr> <td>Published</td> <td width="25">
</td> <td>4 May 2006</td> </tr> </tbody></table>
Abstract (provisional)
Background
Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma, TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).
Methods
A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma, TNF-alpha and IL-10 for their associations with SARS.
Results
IFN-gamma +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P<0.001). Individuals with IFN-gamma +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-alpha were not associated with SARS susceptibility.
Conclusions
IFN-gamma +874A allele was shown to be a risk factor in SARS susceptibility.
http://www.biomedcentral.com/1471-2334/6/82/abstract
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