tetano
Editor, Senior Moderator
BMC Infect Dis
. 2020 Oct 19;20(1):777.
doi: 10.1186/s12879-020-05511-8.
The first consecutive 5000 patients with Coronavirus Disease 2019 from Qatar; a nation-wide cohort study
Ali S Omrani[SUP] 1 [/SUP], Muna A Almaslamani[SUP] 2 [/SUP], Joanne Daghfal[SUP] 2 [/SUP], Rand A Alattar[SUP] 2 [/SUP], Mohamed Elgara[SUP] 3 [/SUP], Shahd H Shaar[SUP] 2 [/SUP], Tawheeda B H Ibrahim[SUP] 2 [/SUP], Ahmed Zaqout[SUP] 2 [/SUP], Dana Bakdach[SUP] 4 [/SUP], Abdelrauof M Akkari[SUP] 4 [/SUP], Anas Baiou[SUP] 4 [/SUP], Bassem Alhariri[SUP] 5 [/SUP], Reem Elajez[SUP] 6 [/SUP], Ahmed A M Husain[SUP] 2 [/SUP], Mohamed N Badawi[SUP] 2 [/SUP], Fatma Ben Abid[SUP] 2 [/SUP], Sulieman H Abu Jarir[SUP] 2 [/SUP], Shiema Abdalla[SUP] 2 [/SUP], Anvar Kaleeckal[SUP] 7 [/SUP], Kris Choda[SUP] 7 [/SUP], Venkateswara R Chinta[SUP] 7 [/SUP], Mohamed A Sherbash[SUP] 8 [/SUP], Khalil Al-Ismail[SUP] 2 [/SUP], Mohammed Abukhattab[SUP] 2 [/SUP], Ali Ait Hssain[SUP] 4 [/SUP], Peter V Coyle[SUP] 9 [/SUP], Roberto Bertollini[SUP] 10 [/SUP], Michael P Frenneaux[SUP] 11 [/SUP], Abdullatif Alkhal[SUP] 2 [/SUP], Hanan M Al-Kuwari[SUP] 10 [/SUP]
Affiliations
Abstract
Background: There are limited data on Coronavirus Disease 2019 (COVID-19) outcomes at a national level, and none after 60 days of follow up. The aim of this study was to describe national, 60-day all-cause mortality associated with COVID-19, and to identify risk factors associated with admission to an intensive care unit (ICU).
Methods: This was a retrospective cohort study including the first consecutive 5000 patients with COVID-19 in Qatar who completed 60 days of follow up by June 17, 2020. The primary outcome was all-cause mortality at 60 days after COVID-19 diagnosis. In addition, we explored risk factors for admission to ICU.
Results: Included patients were diagnosed with COVID-19 between February 28 and April 17, 2020. The majority (4436, 88.7%) were males and the median age was 35 years [interquartile range (IQR) 28-43]. By 60 days after COVID-19 diagnosis, 14 patients (0.28%) had died, 10 (0.2%) were still in hospital, and two (0.04%) were still in ICU. Fatal COVID-19 cases had a median age of 59.5 years (IQR 55.8-68), and were mostly males (13, 92.9%). All included pregnant women (26, 0.5%), children (131, 2.6%), and healthcare workers (135, 2.7%) were alive and not hospitalized at the end of follow up. A total of 1424 patients (28.5%) required hospitalization, out of which 108 (7.6%) were admitted to ICU. Most frequent co-morbidities in hospitalized adults were diabetes (23.2%), and hypertension (20.7%). Multivariable logistic regression showed that older age [adjusted odds ratio (aOR) 1.041, 95% confidence interval (CI) 1.022-1.061 per year increase; P < 0.001], male sex (aOR 4.375, 95% CI 1.964-9.744; P < 0.001), diabetes (aOR 1.698, 95% CI 1.050-2.746; P 0.031), chronic kidney disease (aOR 3.590, 95% CI 1.596-8.079, P 0.002), and higher BMI (aOR 1.067, 95% CI 1.027-1.108 per unit increase; P 0.001), were all independently associated with increased risk of ICU admission.
Conclusions: In a relatively younger national cohort with a low co-morbidity burden, COVID-19 was associated with low all-cause mortality. Independent risk factors for ICU admission included older age, male sex, higher BMI, and co-existing diabetes or chronic kidney disease.
Keywords: COVID-19; Coronavirus; Mortality; Qatar; SARS-CoV-2.
. 2020 Oct 19;20(1):777.
doi: 10.1186/s12879-020-05511-8.
The first consecutive 5000 patients with Coronavirus Disease 2019 from Qatar; a nation-wide cohort study
Ali S Omrani[SUP] 1 [/SUP], Muna A Almaslamani[SUP] 2 [/SUP], Joanne Daghfal[SUP] 2 [/SUP], Rand A Alattar[SUP] 2 [/SUP], Mohamed Elgara[SUP] 3 [/SUP], Shahd H Shaar[SUP] 2 [/SUP], Tawheeda B H Ibrahim[SUP] 2 [/SUP], Ahmed Zaqout[SUP] 2 [/SUP], Dana Bakdach[SUP] 4 [/SUP], Abdelrauof M Akkari[SUP] 4 [/SUP], Anas Baiou[SUP] 4 [/SUP], Bassem Alhariri[SUP] 5 [/SUP], Reem Elajez[SUP] 6 [/SUP], Ahmed A M Husain[SUP] 2 [/SUP], Mohamed N Badawi[SUP] 2 [/SUP], Fatma Ben Abid[SUP] 2 [/SUP], Sulieman H Abu Jarir[SUP] 2 [/SUP], Shiema Abdalla[SUP] 2 [/SUP], Anvar Kaleeckal[SUP] 7 [/SUP], Kris Choda[SUP] 7 [/SUP], Venkateswara R Chinta[SUP] 7 [/SUP], Mohamed A Sherbash[SUP] 8 [/SUP], Khalil Al-Ismail[SUP] 2 [/SUP], Mohammed Abukhattab[SUP] 2 [/SUP], Ali Ait Hssain[SUP] 4 [/SUP], Peter V Coyle[SUP] 9 [/SUP], Roberto Bertollini[SUP] 10 [/SUP], Michael P Frenneaux[SUP] 11 [/SUP], Abdullatif Alkhal[SUP] 2 [/SUP], Hanan M Al-Kuwari[SUP] 10 [/SUP]
Affiliations
- PMID: 33076848
- DOI: 10.1186/s12879-020-05511-8
Abstract
Background: There are limited data on Coronavirus Disease 2019 (COVID-19) outcomes at a national level, and none after 60 days of follow up. The aim of this study was to describe national, 60-day all-cause mortality associated with COVID-19, and to identify risk factors associated with admission to an intensive care unit (ICU).
Methods: This was a retrospective cohort study including the first consecutive 5000 patients with COVID-19 in Qatar who completed 60 days of follow up by June 17, 2020. The primary outcome was all-cause mortality at 60 days after COVID-19 diagnosis. In addition, we explored risk factors for admission to ICU.
Results: Included patients were diagnosed with COVID-19 between February 28 and April 17, 2020. The majority (4436, 88.7%) were males and the median age was 35 years [interquartile range (IQR) 28-43]. By 60 days after COVID-19 diagnosis, 14 patients (0.28%) had died, 10 (0.2%) were still in hospital, and two (0.04%) were still in ICU. Fatal COVID-19 cases had a median age of 59.5 years (IQR 55.8-68), and were mostly males (13, 92.9%). All included pregnant women (26, 0.5%), children (131, 2.6%), and healthcare workers (135, 2.7%) were alive and not hospitalized at the end of follow up. A total of 1424 patients (28.5%) required hospitalization, out of which 108 (7.6%) were admitted to ICU. Most frequent co-morbidities in hospitalized adults were diabetes (23.2%), and hypertension (20.7%). Multivariable logistic regression showed that older age [adjusted odds ratio (aOR) 1.041, 95% confidence interval (CI) 1.022-1.061 per year increase; P < 0.001], male sex (aOR 4.375, 95% CI 1.964-9.744; P < 0.001), diabetes (aOR 1.698, 95% CI 1.050-2.746; P 0.031), chronic kidney disease (aOR 3.590, 95% CI 1.596-8.079, P 0.002), and higher BMI (aOR 1.067, 95% CI 1.027-1.108 per unit increase; P 0.001), were all independently associated with increased risk of ICU admission.
Conclusions: In a relatively younger national cohort with a low co-morbidity burden, COVID-19 was associated with low all-cause mortality. Independent risk factors for ICU admission included older age, male sex, higher BMI, and co-existing diabetes or chronic kidney disease.
Keywords: COVID-19; Coronavirus; Mortality; Qatar; SARS-CoV-2.