tetano
Editor, Senior Moderator
BMC Infect Dis
. 2023 Feb 6;23(1):75.
doi: 10.1186/s12879-023-08010-8.
The clinical outcomes of COVID-19 critically ill patients co-infected with other respiratory viruses: a multicenter, cohort study
Khalid Al Sulaiman[SUP] 1 2 3 4 [/SUP], Ohoud Aljuhani[SUP] 5 [/SUP], Hisham A Badreldin[SUP] 6 7 8 [/SUP], Ghazwa B Korayem[SUP] 9 [/SUP], Abeer A Alenazi[SUP] 10 [/SUP], Ahlam H Alharbi[SUP] 11 [/SUP], Albandari Alghamdi[SUP] 9 [/SUP], Alaa Alhubaishi[SUP] 9 [/SUP], Ali F Altebainawi[SUP] 12 [/SUP], Mohammad Bosaeed[SUP] 13 14 [/SUP], Rand Alotaibi[SUP] 9 [/SUP], Ahad Alawad[SUP] 9 [/SUP], Nirvana Alnajjar[SUP] 9 [/SUP], Khalid Bin Saleh[SUP] 6 7 8 [/SUP], Walaa A Sait[SUP] 15 [/SUP], Samiah Alsohimi[SUP] 16 17 [/SUP], Meshari M Alanizy[SUP] 7 [/SUP], Sarah A Almuqbil[SUP] 11 [/SUP], Ibrahim Al Sulaihim[SUP] 18 [/SUP], Ramesh Vishwakarma[SUP] 19 [/SUP], Mai Alalawi[SUP] 20 [/SUP], Fatimah Alhassan[SUP] 6 8 [/SUP], Suliman Alghnam[SUP] 21 [/SUP]
Affiliations
Abstract
Background: Previous studies have shown that non-critically ill COVID-19 patients co-infected with other respiratory viruses have poor clinical outcomes. However, limited studies focused on this co-infections in critically ill patients. This study aims to evaluate the clinical outcomes of critically ill patients infected with COVID-19 and co-infected by other respiratory viruses.
Methods: A multicenter retrospective cohort study was conducted for all adult patients with COVID-19 who were hospitalized in the ICUs between March, 2020 and July, 2021. Eligible patients were sub-categorized into two groups based on simultaneous co-infection with other respiratory viruses throughout their ICU stay. Influenza A or B, Human Adenovirus (AdV), Human Coronavirus (i.e., 229E, HKU1, NL63, or OC43), Human Metapneumovirus, Human Rhinovirus/Enterovirus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Parainfluenza virus, and Respiratory Syncytial Virus (RSV) were among the respiratory viral infections screened. Patients were followed until discharge from the hospital or in-hospital death.
Results: A total of 836 patients were included in the final analysis. Eleven patients (1.3%) were infected concomitantly with other respiratory viruses. Rhinovirus/Enterovirus (38.5%) was the most commonly reported co-infection. No difference was observed between the two groups regarding the 30-day mortality (HR 0.39, 95% CI 0.13, 1.20; p = 0.10). The in-hospital mortality was significantly lower among co-infected patients with other respiratory viruses compared with patients who were infected with COVID-19 alone (HR 0.32 95% CI 0.10, 0.97; p = 0.04). Patients concomitantly infected with other respiratory viruses had longer median mechanical ventilation (MV) duration and hospital length of stay (LOS).
Conclusion: Critically ill patients with COVID-19 who were concomitantly infected with other respiratory viruses had comparable 30-day mortality to those not concomitantly infected. Further proactive testing and care may be required in the case of co-infection with respiratory viruses and COVID-19. The results of our study need to be confirmed by larger studies.
Keywords: COVID19; Coinfection; Coronavirus disease; Critically ill; MV duration; Mortality; Outcomes; Respiratory viruses.
. 2023 Feb 6;23(1):75.
doi: 10.1186/s12879-023-08010-8.
The clinical outcomes of COVID-19 critically ill patients co-infected with other respiratory viruses: a multicenter, cohort study
Khalid Al Sulaiman[SUP] 1 2 3 4 [/SUP], Ohoud Aljuhani[SUP] 5 [/SUP], Hisham A Badreldin[SUP] 6 7 8 [/SUP], Ghazwa B Korayem[SUP] 9 [/SUP], Abeer A Alenazi[SUP] 10 [/SUP], Ahlam H Alharbi[SUP] 11 [/SUP], Albandari Alghamdi[SUP] 9 [/SUP], Alaa Alhubaishi[SUP] 9 [/SUP], Ali F Altebainawi[SUP] 12 [/SUP], Mohammad Bosaeed[SUP] 13 14 [/SUP], Rand Alotaibi[SUP] 9 [/SUP], Ahad Alawad[SUP] 9 [/SUP], Nirvana Alnajjar[SUP] 9 [/SUP], Khalid Bin Saleh[SUP] 6 7 8 [/SUP], Walaa A Sait[SUP] 15 [/SUP], Samiah Alsohimi[SUP] 16 17 [/SUP], Meshari M Alanizy[SUP] 7 [/SUP], Sarah A Almuqbil[SUP] 11 [/SUP], Ibrahim Al Sulaihim[SUP] 18 [/SUP], Ramesh Vishwakarma[SUP] 19 [/SUP], Mai Alalawi[SUP] 20 [/SUP], Fatimah Alhassan[SUP] 6 8 [/SUP], Suliman Alghnam[SUP] 21 [/SUP]
Affiliations
- PMID: 36747136
- PMCID: PMC9901824
- DOI: 10.1186/s12879-023-08010-8
Abstract
Background: Previous studies have shown that non-critically ill COVID-19 patients co-infected with other respiratory viruses have poor clinical outcomes. However, limited studies focused on this co-infections in critically ill patients. This study aims to evaluate the clinical outcomes of critically ill patients infected with COVID-19 and co-infected by other respiratory viruses.
Methods: A multicenter retrospective cohort study was conducted for all adult patients with COVID-19 who were hospitalized in the ICUs between March, 2020 and July, 2021. Eligible patients were sub-categorized into two groups based on simultaneous co-infection with other respiratory viruses throughout their ICU stay. Influenza A or B, Human Adenovirus (AdV), Human Coronavirus (i.e., 229E, HKU1, NL63, or OC43), Human Metapneumovirus, Human Rhinovirus/Enterovirus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Parainfluenza virus, and Respiratory Syncytial Virus (RSV) were among the respiratory viral infections screened. Patients were followed until discharge from the hospital or in-hospital death.
Results: A total of 836 patients were included in the final analysis. Eleven patients (1.3%) were infected concomitantly with other respiratory viruses. Rhinovirus/Enterovirus (38.5%) was the most commonly reported co-infection. No difference was observed between the two groups regarding the 30-day mortality (HR 0.39, 95% CI 0.13, 1.20; p = 0.10). The in-hospital mortality was significantly lower among co-infected patients with other respiratory viruses compared with patients who were infected with COVID-19 alone (HR 0.32 95% CI 0.10, 0.97; p = 0.04). Patients concomitantly infected with other respiratory viruses had longer median mechanical ventilation (MV) duration and hospital length of stay (LOS).
Conclusion: Critically ill patients with COVID-19 who were concomitantly infected with other respiratory viruses had comparable 30-day mortality to those not concomitantly infected. Further proactive testing and care may be required in the case of co-infection with respiratory viruses and COVID-19. The results of our study need to be confirmed by larger studies.
Keywords: COVID19; Coinfection; Coronavirus disease; Critically ill; MV duration; Mortality; Outcomes; Respiratory viruses.