tetano
Editor, Senior Moderator
BMC Infect Dis
. 2021 Apr 20;21(1):371.
doi: 10.1186/s12879-021-06057-z.
The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
Liulin Wang[SUP] 1 2 [/SUP], Xiaobin Cheng[SUP] 1 2 [/SUP], Qiufen Dong[SUP] 1 2 [/SUP], Chenliang Zhou[SUP] 3 [/SUP], Yeming Wang[SUP] 4 [/SUP], Bin Song[SUP] 5 [/SUP], Weinan Li[SUP] 2 6 [/SUP], Min Wang[SUP] 1 2 [/SUP], Rui Qin[SUP] 1 2 [/SUP], Qi Long[SUP] 1 2 [/SUP], Juan Liu[SUP] 1 2 [/SUP], Jing Li[SUP] 1 2 [/SUP], Dan Li[SUP] 1 2 [/SUP], Gang Li[SUP] 7 8 [/SUP], Yuanming Ba[SUP] 9 10 [/SUP]
Affiliations
Abstract
Background: The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients.
Methods: We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression.
Results: In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 ? 10[SUP]9[/SUP]/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality.
Conclusions: COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.
Keywords: COVID-19; Cox proportional hazards model; Laboratory tests; Risk factors.
. 2021 Apr 20;21(1):371.
doi: 10.1186/s12879-021-06057-z.
The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
Liulin Wang[SUP] 1 2 [/SUP], Xiaobin Cheng[SUP] 1 2 [/SUP], Qiufen Dong[SUP] 1 2 [/SUP], Chenliang Zhou[SUP] 3 [/SUP], Yeming Wang[SUP] 4 [/SUP], Bin Song[SUP] 5 [/SUP], Weinan Li[SUP] 2 6 [/SUP], Min Wang[SUP] 1 2 [/SUP], Rui Qin[SUP] 1 2 [/SUP], Qi Long[SUP] 1 2 [/SUP], Juan Liu[SUP] 1 2 [/SUP], Jing Li[SUP] 1 2 [/SUP], Dan Li[SUP] 1 2 [/SUP], Gang Li[SUP] 7 8 [/SUP], Yuanming Ba[SUP] 9 10 [/SUP]
Affiliations
- PMID: 33879073
- DOI: 10.1186/s12879-021-06057-z
Abstract
Background: The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients.
Methods: We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression.
Results: In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 ? 10[SUP]9[/SUP]/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality.
Conclusions: COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.
Keywords: COVID-19; Cox proportional hazards model; Laboratory tests; Risk factors.