tetano
Editor, Senior Moderator
BMC Infect Dis
. 2024 Jan 2;24(1):3.
doi: 10.1186/s12879-023-08859-9. Propensity score matched analysis for the safety and effectiveness of remdesivir in COVID-19 patients with renal impairment
Eunmi Yang[SUP] 1 [/SUP], Han Zo Choi[SUP] 2 [/SUP], Subin Kim[SUP] 1 [/SUP], Dong Hyun Oh[SUP] 1 [/SUP], Mi Young Ahn[SUP] 1 [/SUP], Sinyoung Ham[SUP] 3 [/SUP], Eunyoung Lee[SUP] 4 [/SUP], Jaehyun Jeon[SUP] 5 [/SUP], Min-Kyung Kim[SUP] 5 [/SUP], Hee-Chang Jang[SUP] 6 [/SUP], Sang-Won Park[SUP] #[/SUP][SUP] 7 [/SUP], Jae-Phil Choi[SUP] #[/SUP][SUP] 8 [/SUP]
Affiliations
Backgrounds: Remdesivir (RDV) is an antiviral agent approved for the treatment of coronavirus disease 2019 (COVID-19); however, is not recommended for patients with renal impairment. Due to limitations associated with prospective clinical trials, real-world data on the safety and efficacy of RDV in patients with renal impairment are necessary.
Methods: Propensity score-matched (PSM) retrospective analysis was conducted between March 2020 and September 2022 in COVID-19 patients with an eGFR < 30 mL/min in four Korean hospitals. The RDV treatment group was matched to the untreated control group. The safety and clinical outcomes in patients who received RDV were analyzed.
Results: A total of 564 patients were enrolled; 229 patients received RDV either for treatment or prophylaxis. On day 5, no difference in nephrotoxicity was observed between the two groups, and liver enzyme levels were within the normal range. In multivariate analysis for new dialysis, RDV treatment was not a risk factor for new dialysis. Among the 564 patients, 417 were indicated for a 5-day course of RDV treatment and 211 patients were treated with RDV. After PSM, no differences in the clinical outcomes were observed between the two groups.
Conclusion: RDV use in COVID-19 patients with renal impairment did not result in significant nephrotoxicity or hepatotoxicity.
Keywords: COVID-19; Propensity Score; Remdesivir; Renal insufficiency; Safety.
. 2024 Jan 2;24(1):3.
doi: 10.1186/s12879-023-08859-9. Propensity score matched analysis for the safety and effectiveness of remdesivir in COVID-19 patients with renal impairment
Eunmi Yang[SUP] 1 [/SUP], Han Zo Choi[SUP] 2 [/SUP], Subin Kim[SUP] 1 [/SUP], Dong Hyun Oh[SUP] 1 [/SUP], Mi Young Ahn[SUP] 1 [/SUP], Sinyoung Ham[SUP] 3 [/SUP], Eunyoung Lee[SUP] 4 [/SUP], Jaehyun Jeon[SUP] 5 [/SUP], Min-Kyung Kim[SUP] 5 [/SUP], Hee-Chang Jang[SUP] 6 [/SUP], Sang-Won Park[SUP] #[/SUP][SUP] 7 [/SUP], Jae-Phil Choi[SUP] #[/SUP][SUP] 8 [/SUP]
Affiliations
- PMID: 38166787
- DOI: 10.1186/s12879-023-08859-9
Backgrounds: Remdesivir (RDV) is an antiviral agent approved for the treatment of coronavirus disease 2019 (COVID-19); however, is not recommended for patients with renal impairment. Due to limitations associated with prospective clinical trials, real-world data on the safety and efficacy of RDV in patients with renal impairment are necessary.
Methods: Propensity score-matched (PSM) retrospective analysis was conducted between March 2020 and September 2022 in COVID-19 patients with an eGFR < 30 mL/min in four Korean hospitals. The RDV treatment group was matched to the untreated control group. The safety and clinical outcomes in patients who received RDV were analyzed.
Results: A total of 564 patients were enrolled; 229 patients received RDV either for treatment or prophylaxis. On day 5, no difference in nephrotoxicity was observed between the two groups, and liver enzyme levels were within the normal range. In multivariate analysis for new dialysis, RDV treatment was not a risk factor for new dialysis. Among the 564 patients, 417 were indicated for a 5-day course of RDV treatment and 211 patients were treated with RDV. After PSM, no differences in the clinical outcomes were observed between the two groups.
Conclusion: RDV use in COVID-19 patients with renal impairment did not result in significant nephrotoxicity or hepatotoxicity.
Keywords: COVID-19; Propensity Score; Remdesivir; Renal insufficiency; Safety.