tetano
Editor, Senior Moderator
BMC Infect Dis
. 2024 Mar 8;24(1):300.
doi: 10.1186/s12879-024-09108-3. Post-recovery health domain scores among outpatients by SARS-CoV-2 testing status during the pre-Delta period
Jennifer P King[SUP] 1 [/SUP], Jessie R Chung[SUP] 2 [/SUP], James G Donahue[SUP] 3 [/SUP], Emily T Martin[SUP] 4 [/SUP], Aleda M Leis[SUP] 4 [/SUP], Arnold S Monto[SUP] 4 [/SUP], Manjusha Gaglani[SUP] 5 6 [/SUP], Kayan Dunnigan[SUP] 7 [/SUP], Chandni Raiyani[SUP] 7 [/SUP], Sharon Saydah[SUP] 8 [/SUP], Brendan Flannery[SUP] 9 [/SUP], Edward A Belongia[SUP] 3 [/SUP]
Affiliations
Background: Symptoms of COVID-19 including fatigue and dyspnea, may persist for weeks to months after SARS-CoV-2 infection. This study compared self-reported disability among SARS-CoV-2-positive and negative persons with mild to moderate COVID-19-like illness who presented for outpatient care before widespread COVID-19 vaccination.
Methods: Unvaccinated adults with COVID-19-like illness enrolled within 10 days of illness onset at three US Flu Vaccine Effectiveness Network sites were tested for SARS-CoV-2 by molecular assay. Enrollees completed an enrollment questionnaire and two follow-up surveys (7-24 days and 2-7 months after illness onset) online or by phone to assess illness characteristics and health status. The second follow-up survey included questions measuring global health, physical function, fatigue, and dyspnea. Scores in the four domains were compared by participants' SARS-CoV-2 test results in univariate analysis and multivariable Gamma regression.
Results: During September 22, 2020 - February 13, 2021, 2712 eligible adults were enrolled, 1541 completed the first follow-up survey, and 650 completed the second follow-up survey. SARS-CoV-2-positive participants were more likely to report fever at acute illness but were otherwise comparable to SARS-CoV-2-negative participants. At first follow-up, SARS-CoV-2-positive participants were less likely to have reported fully or mostly recovered from their illness compared to SARS-CoV-2-negative participants. At second follow-up, no differences by SARS-CoV-2 test results were detected in the four domains in the multivariable model.
Conclusion: Self-reported disability was similar among outpatient SARS-CoV-2-positive and -negative adults 2-7 months after illness onset.
Keywords: COVID-19; Long COVID; Post-COVID-19 condition.
. 2024 Mar 8;24(1):300.
doi: 10.1186/s12879-024-09108-3. Post-recovery health domain scores among outpatients by SARS-CoV-2 testing status during the pre-Delta period
Jennifer P King[SUP] 1 [/SUP], Jessie R Chung[SUP] 2 [/SUP], James G Donahue[SUP] 3 [/SUP], Emily T Martin[SUP] 4 [/SUP], Aleda M Leis[SUP] 4 [/SUP], Arnold S Monto[SUP] 4 [/SUP], Manjusha Gaglani[SUP] 5 6 [/SUP], Kayan Dunnigan[SUP] 7 [/SUP], Chandni Raiyani[SUP] 7 [/SUP], Sharon Saydah[SUP] 8 [/SUP], Brendan Flannery[SUP] 9 [/SUP], Edward A Belongia[SUP] 3 [/SUP]
Affiliations
- PMID: 38454352
- PMCID: PMC10921777
- DOI: 10.1186/s12879-024-09108-3
Background: Symptoms of COVID-19 including fatigue and dyspnea, may persist for weeks to months after SARS-CoV-2 infection. This study compared self-reported disability among SARS-CoV-2-positive and negative persons with mild to moderate COVID-19-like illness who presented for outpatient care before widespread COVID-19 vaccination.
Methods: Unvaccinated adults with COVID-19-like illness enrolled within 10 days of illness onset at three US Flu Vaccine Effectiveness Network sites were tested for SARS-CoV-2 by molecular assay. Enrollees completed an enrollment questionnaire and two follow-up surveys (7-24 days and 2-7 months after illness onset) online or by phone to assess illness characteristics and health status. The second follow-up survey included questions measuring global health, physical function, fatigue, and dyspnea. Scores in the four domains were compared by participants' SARS-CoV-2 test results in univariate analysis and multivariable Gamma regression.
Results: During September 22, 2020 - February 13, 2021, 2712 eligible adults were enrolled, 1541 completed the first follow-up survey, and 650 completed the second follow-up survey. SARS-CoV-2-positive participants were more likely to report fever at acute illness but were otherwise comparable to SARS-CoV-2-negative participants. At first follow-up, SARS-CoV-2-positive participants were less likely to have reported fully or mostly recovered from their illness compared to SARS-CoV-2-negative participants. At second follow-up, no differences by SARS-CoV-2 test results were detected in the four domains in the multivariable model.
Conclusion: Self-reported disability was similar among outpatient SARS-CoV-2-positive and -negative adults 2-7 months after illness onset.
Keywords: COVID-19; Long COVID; Post-COVID-19 condition.