tetano
Editor, Senior Moderator
BMC Infect Dis
. 2020 Sep 22;20(1):698.
doi: 10.1186/s12879-020-05419-3.
COVID-19 confirmed patients with negative antibodies results
Jian Wang[SUP] 1 2 [/SUP], Chong Chen[SUP] 3 [/SUP], Qilin Li[SUP] 1 2 [/SUP], Pengcheng Cai[SUP] 1 [/SUP], Zheng Wang[SUP] 4 5 [/SUP], Lin Wang[SUP] 6 7 [/SUP]
Affiliations
Abstract
Background: A new coronavirus disease 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of patients may have difficulty in generating IgM or IgG antibodies against SARS-CoV-2, and little attention has been paid to them.
Case presentations: We present two cases of confirmed COVID-19 patients and characterize their initial symptoms, chest CT results, medication, and laboratory test results in detail (including RT-PCR, IgM/ IgG, cytokine and blood cell counts).
Conclusion: Both of patients with confirmed COVID-19 pneumonia failed to produce either IgM or IgG even 40 to 50 days after their symptoms onset. This work provides evidence demonstrating that at least a small proportion of patients may have difficulty in rapidly gaining immunity against SARS-CoV-2.
Keywords: COVID-19; Case report; IgG; IgM; Negative antibodies results.
. 2020 Sep 22;20(1):698.
doi: 10.1186/s12879-020-05419-3.
COVID-19 confirmed patients with negative antibodies results
Jian Wang[SUP] 1 2 [/SUP], Chong Chen[SUP] 3 [/SUP], Qilin Li[SUP] 1 2 [/SUP], Pengcheng Cai[SUP] 1 [/SUP], Zheng Wang[SUP] 4 5 [/SUP], Lin Wang[SUP] 6 7 [/SUP]
Affiliations
- PMID: 32962655
- DOI: 10.1186/s12879-020-05419-3
Abstract
Background: A new coronavirus disease 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of patients may have difficulty in generating IgM or IgG antibodies against SARS-CoV-2, and little attention has been paid to them.
Case presentations: We present two cases of confirmed COVID-19 patients and characterize their initial symptoms, chest CT results, medication, and laboratory test results in detail (including RT-PCR, IgM/ IgG, cytokine and blood cell counts).
Conclusion: Both of patients with confirmed COVID-19 pneumonia failed to produce either IgM or IgG even 40 to 50 days after their symptoms onset. This work provides evidence demonstrating that at least a small proportion of patients may have difficulty in rapidly gaining immunity against SARS-CoV-2.
Keywords: COVID-19; Case report; IgG; IgM; Negative antibodies results.