tetano
Editor, Senior Moderator
BMC Infect Dis
. 2022 Jul 15;22(1):618.
doi: 10.1186/s12879-022-07555-4.
Comparison of clinical characteristics and outcomes of hospitalized patients with seasonal coronavirus infection and COVID-19: a retrospective cohort study
Guillermo Rodriguez-Nava[SUP] 1 [/SUP], Goar Egoryan[SUP] 2 [/SUP], Tianyu Dong[SUP] 2 [/SUP], Qishuo Zhang[SUP] 2 [/SUP], Elise Hyser[SUP] 2 [/SUP], Bidhya Poudel[SUP] 2 [/SUP], Maria Adriana Yanez-Bello[SUP] 2 [/SUP], Daniela Patricia Trelles-Garcia[SUP] 2 [/SUP], Chul Won Chung[SUP] 2 [/SUP], Bimatshu Pyakuryal[SUP] 2 [/SUP], Taraz Imani-Ramos[SUP] 3 [/SUP], Valeria Patricia Trelles-Garcia[SUP] 4 [/SUP], Daniel Sebastian Bustamante-Soliz[SUP] 5 [/SUP], Jonathan J Stake[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Unlike SARS-CoV and MERS-C0V, SARS-CoV-2 has the potential to become a recurrent seasonal infection; hence, it is essential to compare the clinical spectrum of COVID-19 to the existent endemic coronaviruses. We conducted a retrospective cohort study of hospitalized patients with seasonal coronavirus (sCoV) infection and COVID-19 to compare their clinical characteristics and outcomes.
Methods: A total of 190 patients hospitalized with any documented respiratory tract infection and a positive respiratory viral panel for sCoV from January 1, 2011, to March 31, 2020, were included. Those patients were compared with 190 hospitalized adult patients with molecularly confirmed symptomatic COVID-19 admitted from March 1, 2020, to May 25, 2020.
Results: Among 190 patients with sCoV infection, the Human Coronavirus-OC93 was the most common coronavirus with 47.4% of the cases. When comparing demographics and baseline characteristics, both groups were of similar age (sCoV: 74 years vs. COVID-19: 69 years) and presented similar proportions of two or more comorbidities (sCoV: 85.8% vs. COVID-19: 81.6%). More patients with COVID-19 presented with severe disease (78.4% vs. 67.9%), sepsis (36.3% vs. 20.5%), and developed ARDS (15.8% vs. 2.6%) compared to patients with sCoV infection. Patients with COVID-19 had an almost fourfold increased risk of in-hospital death than patients with sCoV infection (OR 3.86, CI 1.99-7.49; p < .001).
Conclusion: Hospitalized patients with COVID-19 had similar demographics and baseline characteristics to hospitalized patients with sCoV infection; however, patients with COVID-19 presented with higher disease severity, had a higher case-fatality rate, and increased risk of death than patients with sCoV. Clinical findings alone may not help confirm or exclude the diagnosis of COVID-19 during high acute respiratory illness seasons. The respiratory multiplex panel by PCR that includes SARS-CoV-2 in conjunction with local epidemiological data may be a valuable tool to assist clinicians with management decisions.
Keywords: COVID-19; Human coronavirus; MERS; SARS; Seasonal coronavirus.
. 2022 Jul 15;22(1):618.
doi: 10.1186/s12879-022-07555-4.
Comparison of clinical characteristics and outcomes of hospitalized patients with seasonal coronavirus infection and COVID-19: a retrospective cohort study
Guillermo Rodriguez-Nava[SUP] 1 [/SUP], Goar Egoryan[SUP] 2 [/SUP], Tianyu Dong[SUP] 2 [/SUP], Qishuo Zhang[SUP] 2 [/SUP], Elise Hyser[SUP] 2 [/SUP], Bidhya Poudel[SUP] 2 [/SUP], Maria Adriana Yanez-Bello[SUP] 2 [/SUP], Daniela Patricia Trelles-Garcia[SUP] 2 [/SUP], Chul Won Chung[SUP] 2 [/SUP], Bimatshu Pyakuryal[SUP] 2 [/SUP], Taraz Imani-Ramos[SUP] 3 [/SUP], Valeria Patricia Trelles-Garcia[SUP] 4 [/SUP], Daniel Sebastian Bustamante-Soliz[SUP] 5 [/SUP], Jonathan J Stake[SUP] 6 [/SUP]
Affiliations
- PMID: 35840902
- DOI: 10.1186/s12879-022-07555-4
Abstract
Background: Unlike SARS-CoV and MERS-C0V, SARS-CoV-2 has the potential to become a recurrent seasonal infection; hence, it is essential to compare the clinical spectrum of COVID-19 to the existent endemic coronaviruses. We conducted a retrospective cohort study of hospitalized patients with seasonal coronavirus (sCoV) infection and COVID-19 to compare their clinical characteristics and outcomes.
Methods: A total of 190 patients hospitalized with any documented respiratory tract infection and a positive respiratory viral panel for sCoV from January 1, 2011, to March 31, 2020, were included. Those patients were compared with 190 hospitalized adult patients with molecularly confirmed symptomatic COVID-19 admitted from March 1, 2020, to May 25, 2020.
Results: Among 190 patients with sCoV infection, the Human Coronavirus-OC93 was the most common coronavirus with 47.4% of the cases. When comparing demographics and baseline characteristics, both groups were of similar age (sCoV: 74 years vs. COVID-19: 69 years) and presented similar proportions of two or more comorbidities (sCoV: 85.8% vs. COVID-19: 81.6%). More patients with COVID-19 presented with severe disease (78.4% vs. 67.9%), sepsis (36.3% vs. 20.5%), and developed ARDS (15.8% vs. 2.6%) compared to patients with sCoV infection. Patients with COVID-19 had an almost fourfold increased risk of in-hospital death than patients with sCoV infection (OR 3.86, CI 1.99-7.49; p < .001).
Conclusion: Hospitalized patients with COVID-19 had similar demographics and baseline characteristics to hospitalized patients with sCoV infection; however, patients with COVID-19 presented with higher disease severity, had a higher case-fatality rate, and increased risk of death than patients with sCoV. Clinical findings alone may not help confirm or exclude the diagnosis of COVID-19 during high acute respiratory illness seasons. The respiratory multiplex panel by PCR that includes SARS-CoV-2 in conjunction with local epidemiological data may be a valuable tool to assist clinicians with management decisions.
Keywords: COVID-19; Human coronavirus; MERS; SARS; Seasonal coronavirus.