tetano
Editor, Senior Moderator
BMC Infect Dis
. 2022 Jan 28;22(1):97.
doi: 10.1186/s12879-022-07083-1.
Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine
Andrea Lombardi[SUP] 1 2 3 [/SUP], Giulia Renisi[SUP] 4 [/SUP], Dario Consonni[SUP] 5 [/SUP], Massimo Oggioni[SUP] 6 [/SUP], Patrizia Bono[SUP] 6 [/SUP], Sara Uceda Renteria[SUP] 6 [/SUP], Alessandra Piatti[SUP] 7 [/SUP], Angela Cecilia Pesatori[SUP] 5 8 [/SUP], Silvana Castaldi[SUP] 9 10 [/SUP], Antonio Muscatello[SUP] 4 [/SUP], Luciano Riboldi[SUP] 11 [/SUP], Ferruccio Ceriotti[SUP] 6 [/SUP], Andrea Gori[SUP] 4 12 13 [/SUP], Alessandra Bandera[SUP] 4 12 13 [/SUP]
Affiliations
Abstract
Background: The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had a significant impact worldwide. Vaccines against COVID-19 appear as a tool able to curb out mortality and reduce the circulation of the virus. Little is known so far about the clinical characteristics of individuals who developed SARS-CoV-2 infection after having received the vaccination, as well as the temporal relationship between vaccine administration and symptoms onset.
Methods: Retrospective cohort study among the 3219 healthcare workers (HCWs) of the Fondazione IRCCS Ospedale Maggiore Policlinico of Milano who received a full immunization with the BNT162b2 vaccine and who developed SARS-CoV-2 infection (documented through positive RT-PCR on nasopharyngeal swab) in March-April 2021.
Results: Overall, we have identified 15 HCWs with SARS-CoV-2 infection after vaccination, 7 (46.7%) of them were male and the mean age was 38.4 years (SD 14). In 4 of them, the presence of SARS-CoV-2 anti-nucleocapsid (anti-N) antibodies was assessed before vaccination and resulted positive in 1 case. In all HCWs the presence of SARS-CoV-2 anti-spike (anti-S1) antibodies was assessed, on average 42.2 days after the completion of vaccination, with a mean value of 2055 U/mL (SD 1927.3). SARS-CoV-2 infection was ascertained on average 56.2 days after vaccination. The mean cycle threshold (Ct) of SARS-CoV-2 PCR was 26.4, the lineage was characterized in 9 HCWs. None of the HCWs reported a primary or secondary immunodeficiency. Regarding symptoms, they were reported only by 7 (46.7%) HCWs and appeared on average 55 days after the second dose of vaccination. Of those who reported symptoms, one (14.3%) had fever, 7 (100%) rhinitis/conjunctivitis, 4 (57.1%) taste and smell alterations, none had respiratory symptoms, 4 headache/arthralgia (57.1%) and 1 gastrointestinal symptom (14.3%). All symptoms disappeared in a few days and no other unclassified symptoms were reported.
Conclusions: Infections occurring after vaccination with the BNT162b2 vaccine are mostly asymptomatic and are not associated with the serum titre of anti-S1 antibodies. We did not find a predominance of specific viral variants, with several lineages represented.
Keywords: BNT162b2; COVID-19; SARS-CoV-2; Symptoms; Vaccination.
. 2022 Jan 28;22(1):97.
doi: 10.1186/s12879-022-07083-1.
Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine
Andrea Lombardi[SUP] 1 2 3 [/SUP], Giulia Renisi[SUP] 4 [/SUP], Dario Consonni[SUP] 5 [/SUP], Massimo Oggioni[SUP] 6 [/SUP], Patrizia Bono[SUP] 6 [/SUP], Sara Uceda Renteria[SUP] 6 [/SUP], Alessandra Piatti[SUP] 7 [/SUP], Angela Cecilia Pesatori[SUP] 5 8 [/SUP], Silvana Castaldi[SUP] 9 10 [/SUP], Antonio Muscatello[SUP] 4 [/SUP], Luciano Riboldi[SUP] 11 [/SUP], Ferruccio Ceriotti[SUP] 6 [/SUP], Andrea Gori[SUP] 4 12 13 [/SUP], Alessandra Bandera[SUP] 4 12 13 [/SUP]
Affiliations
- PMID: 35090388
- DOI: 10.1186/s12879-022-07083-1
Abstract
Background: The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had a significant impact worldwide. Vaccines against COVID-19 appear as a tool able to curb out mortality and reduce the circulation of the virus. Little is known so far about the clinical characteristics of individuals who developed SARS-CoV-2 infection after having received the vaccination, as well as the temporal relationship between vaccine administration and symptoms onset.
Methods: Retrospective cohort study among the 3219 healthcare workers (HCWs) of the Fondazione IRCCS Ospedale Maggiore Policlinico of Milano who received a full immunization with the BNT162b2 vaccine and who developed SARS-CoV-2 infection (documented through positive RT-PCR on nasopharyngeal swab) in March-April 2021.
Results: Overall, we have identified 15 HCWs with SARS-CoV-2 infection after vaccination, 7 (46.7%) of them were male and the mean age was 38.4 years (SD 14). In 4 of them, the presence of SARS-CoV-2 anti-nucleocapsid (anti-N) antibodies was assessed before vaccination and resulted positive in 1 case. In all HCWs the presence of SARS-CoV-2 anti-spike (anti-S1) antibodies was assessed, on average 42.2 days after the completion of vaccination, with a mean value of 2055 U/mL (SD 1927.3). SARS-CoV-2 infection was ascertained on average 56.2 days after vaccination. The mean cycle threshold (Ct) of SARS-CoV-2 PCR was 26.4, the lineage was characterized in 9 HCWs. None of the HCWs reported a primary or secondary immunodeficiency. Regarding symptoms, they were reported only by 7 (46.7%) HCWs and appeared on average 55 days after the second dose of vaccination. Of those who reported symptoms, one (14.3%) had fever, 7 (100%) rhinitis/conjunctivitis, 4 (57.1%) taste and smell alterations, none had respiratory symptoms, 4 headache/arthralgia (57.1%) and 1 gastrointestinal symptom (14.3%). All symptoms disappeared in a few days and no other unclassified symptoms were reported.
Conclusions: Infections occurring after vaccination with the BNT162b2 vaccine are mostly asymptomatic and are not associated with the serum titre of anti-S1 antibodies. We did not find a predominance of specific viral variants, with several lineages represented.
Keywords: BNT162b2; COVID-19; SARS-CoV-2; Symptoms; Vaccination.