tetano
Editor, Senior Moderator
BMC Infect Dis
. 2020 Oct 13;20(1):749.
doi: 10.1186/s12879-020-05463-z.
Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study
Tie-Jun Shui[SUP] 1 [/SUP], Chao Li[SUP] 2 [/SUP], Hong-Bing Liu[SUP] 3 [/SUP], Xiaohua Chen[SUP] 4 5 [/SUP], Bi-Ke Zhang[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients.
Methods: The clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China.
Results: In total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/IgM RDT results, respectively.
Conclusions: Some patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation.
Trial registration: Current Controlled Trials ChiCTR2000033580 , Jun 6th 2020. Retrospectively registered.
. 2020 Oct 13;20(1):749.
doi: 10.1186/s12879-020-05463-z.
Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study
Tie-Jun Shui[SUP] 1 [/SUP], Chao Li[SUP] 2 [/SUP], Hong-Bing Liu[SUP] 3 [/SUP], Xiaohua Chen[SUP] 4 5 [/SUP], Bi-Ke Zhang[SUP] 6 [/SUP]
Affiliations
- PMID: 33050892
- PMCID: PMC7552578
- DOI: 10.1186/s12879-020-05463-z
Abstract
Background: Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients.
Methods: The clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China.
Results: In total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/IgM RDT results, respectively.
Conclusions: Some patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation.
Trial registration: Current Controlled Trials ChiCTR2000033580 , Jun 6th 2020. Retrospectively registered.