tetano
Editor, Senior Moderator
BMC Infect Dis
. 2022 Dec 12;22(1):935.
doi: 10.1186/s12879-022-07927-w.
Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
Ho Lee[SUP] 1 [/SUP], Shotaro Chubachi[SUP] 2 [/SUP], Ho Namkoong[SUP] 3 [/SUP], Takanori Asakura[SUP] 1 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Atsuho Morita[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Mayuko Watase[SUP] 1 [/SUP], Tatsuya Kusumoto[SUP] 1 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 [/SUP], Naoki Hasegawa[SUP] 4 [/SUP], Norihiro Harada[SUP] 5 [/SUP], Tetsuya Ueda[SUP] 6 [/SUP], Soichiro Ueda[SUP] 7 [/SUP], Takashi Ishiguro[SUP] 8 [/SUP], Ken Arimura[SUP] 9 [/SUP], Fukuki Saito[SUP] 10 [/SUP], Takashi Yoshiyama[SUP] 11 [/SUP], Yasushi Nakano[SUP] 12 [/SUP], Yoshikazu Mutoh[SUP] 13 [/SUP], Yusuke Suzuki[SUP] 14 [/SUP], Koji Murakami[SUP] 15 [/SUP], Yukinori Okada[SUP] 16 17 18 [/SUP], Ryuji Koike[SUP] 19 [/SUP], Yuko Kitagawa[SUP] 20 [/SUP], Akinori Kimura[SUP] 21 [/SUP], Seiya Imoto[SUP] 22 [/SUP], Satoru Miyano[SUP] 23 [/SUP], Seishi Ogawa[SUP] 24 [/SUP], Takanori Kanai[SUP] 25 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP], Japan COVID-19 Task Force
Collaborators, Affiliations
Abstract
Background: We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant.
Methods: We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged ≥ 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021.
Results: Patients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, ± 18.9]) and fifth (mean age, 50.7 years [SD ± 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD ± 21.5], p < 0.0001), and post-hospitalization complications, such as bacterial infections (21.3%, p < 0.0001), were also noticeable. In addition, there was an increase in the use of drugs such as remdesivir/baricitinib/tocilizumab/steroids during the latter COVID-19 waves. In the fifth COVID-19 wave, patients exhibited a greater number of presenting symptoms, and a higher percentage of patients required oxygen therapy at the time of admission. However, the percentage of patients requiring invasive mechanical ventilation was the highest in the first COVID-19 wave and the mortality rate was the highest in the third COVID-19 wave.
Conclusions: We identified differences in clinical characteristics of hospitalized patients with COVID-19 in each COVID-19 wave up to the fifth COVID-19 wave in Japan. The fifth COVID-19 wave was associated with greater disease severity on admission, the third COVID-19 wave had the highest mortality rate, and the first COVID-19 wave had the highest percentage of patients requiring mechanical ventilation.
Keywords: COVID-19; Hospitalization; Respiratory infection; Wave of infection.
. 2022 Dec 12;22(1):935.
doi: 10.1186/s12879-022-07927-w.
Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
Ho Lee[SUP] 1 [/SUP], Shotaro Chubachi[SUP] 2 [/SUP], Ho Namkoong[SUP] 3 [/SUP], Takanori Asakura[SUP] 1 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Atsuho Morita[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Mayuko Watase[SUP] 1 [/SUP], Tatsuya Kusumoto[SUP] 1 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 [/SUP], Naoki Hasegawa[SUP] 4 [/SUP], Norihiro Harada[SUP] 5 [/SUP], Tetsuya Ueda[SUP] 6 [/SUP], Soichiro Ueda[SUP] 7 [/SUP], Takashi Ishiguro[SUP] 8 [/SUP], Ken Arimura[SUP] 9 [/SUP], Fukuki Saito[SUP] 10 [/SUP], Takashi Yoshiyama[SUP] 11 [/SUP], Yasushi Nakano[SUP] 12 [/SUP], Yoshikazu Mutoh[SUP] 13 [/SUP], Yusuke Suzuki[SUP] 14 [/SUP], Koji Murakami[SUP] 15 [/SUP], Yukinori Okada[SUP] 16 17 18 [/SUP], Ryuji Koike[SUP] 19 [/SUP], Yuko Kitagawa[SUP] 20 [/SUP], Akinori Kimura[SUP] 21 [/SUP], Seiya Imoto[SUP] 22 [/SUP], Satoru Miyano[SUP] 23 [/SUP], Seishi Ogawa[SUP] 24 [/SUP], Takanori Kanai[SUP] 25 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP], Japan COVID-19 Task Force
Collaborators, Affiliations
- PMID: 36510172
- DOI: 10.1186/s12879-022-07927-w
Abstract
Background: We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant.
Methods: We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged ≥ 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021.
Results: Patients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, ± 18.9]) and fifth (mean age, 50.7 years [SD ± 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD ± 21.5], p < 0.0001), and post-hospitalization complications, such as bacterial infections (21.3%, p < 0.0001), were also noticeable. In addition, there was an increase in the use of drugs such as remdesivir/baricitinib/tocilizumab/steroids during the latter COVID-19 waves. In the fifth COVID-19 wave, patients exhibited a greater number of presenting symptoms, and a higher percentage of patients required oxygen therapy at the time of admission. However, the percentage of patients requiring invasive mechanical ventilation was the highest in the first COVID-19 wave and the mortality rate was the highest in the third COVID-19 wave.
Conclusions: We identified differences in clinical characteristics of hospitalized patients with COVID-19 in each COVID-19 wave up to the fifth COVID-19 wave in Japan. The fifth COVID-19 wave was associated with greater disease severity on admission, the third COVID-19 wave had the highest mortality rate, and the first COVID-19 wave had the highest percentage of patients requiring mechanical ventilation.
Keywords: COVID-19; Hospitalization; Respiratory infection; Wave of infection.