tetano
Editor, Senior Moderator
BMC Infect Dis
. 2021 Sep 25;21(1):1002.
doi: 10.1186/s12879-021-06485-x.
A comparison of demographic, epidemiological and clinical characteristics of hospital influenza-related viral pneumonia patients
Bin Fu[SUP] 1 [/SUP], Zhengjie Wu[SUP] 2 [/SUP], Lingtong Huang[SUP] 3 [/SUP], Zhaohui Chai[SUP] 4 [/SUP], Peidong Zheng[SUP] 4 [/SUP], Qinmiao Sun[SUP] 5 [/SUP], Silan Gu[SUP] 2 [/SUP], Qiaomai Xu[SUP] 2 [/SUP], Haiting Feng[SUP] 6 [/SUP], Lingling Tang[SUP] 7 8 [/SUP]
Affiliations
Abstract
Background: Through the comparison of the demographic, epidemiological, and clinical characteristics of hospital human influenza (influenza A (H1N1) pdm09, H3N2, and B)-related and hospitalized avian-origin influenza A (H7N9)-related viral pneumonia patients, find the different between them.
Methods: A retrospective study was conducted in hospitalized influenza-related viral pneumonia patients.
Results: Human influenza A-related patients in the 35-49-year-old group were more than those with B pneumonia patients (p = 0.027), and relatively less in the ≥ 65-year-old group than B pneumonia patients (p = 0.079). The proportion of comorbid condition to human influenza A pneumonia was 58%, lower than B pneumonia and H7N9 pneumonia patients (78% vs. 77.8%; p = 0.013). The proportion of invasive mechanical ventilation (IMV), lymphocytopenia, elevated lactate dehydrogenase to hospitalized human influenza A-related viral pneumonia patients was higher than B pneumonia patients (p < 0.05), but lower than H7N9 pneumonia patients (p < 0.05). In the multivariate analysis, pulmonary consolidation (odds ratio (OR): 13.67; 95% confidence interval (CI) 1.54-121.12; p = 0.019) and positive bacterial culture (sputum) (OR: 7.71; 95% CI 2.48-24.03; p < 0.001) were independently associated with IMV, while shock (OR: 13.16; 95% CI 2.06-84.07; p = 0.006), white blood cell count > 10,000/mm[SUP]3[/SUP] (OR: 7.22; 95% CI 1.47-35.58; p = 0.015) and positive bacterial culture(blood or sputum) (OR: 6.27; 95% CI 1.36-28.85; p = 0.018) were independently associated with death in the three types hospitalized influenza-related viral pneumonia patients.
Conclusions: Hospital influenza B-related viral pneumonia mainly affects the elderly and people with underlying diseases, while human influenza A pneumonia mainly affects the young adults; however, the mortality was similar. The hospitalized human influenza A-related viral pneumonia patients was severer than B pneumonia patients, but milder than H7N9 pneumonia patients. Pulmonary consolidation and positive bacterial culture (sputum) were independently associated with IMV, while shock, white blood cell count > 10,000/mm[SUP]3[/SUP], and positive bacterial culture (blood or sputum) were independently associated with death to three types hospitalized influenza-related viral pneumonia patients.
Keywords: Avian-origin influenza H7N9; Human influenza A; Influenza B; Severe cases; Viral pneumonia.
. 2021 Sep 25;21(1):1002.
doi: 10.1186/s12879-021-06485-x.
A comparison of demographic, epidemiological and clinical characteristics of hospital influenza-related viral pneumonia patients
Bin Fu[SUP] 1 [/SUP], Zhengjie Wu[SUP] 2 [/SUP], Lingtong Huang[SUP] 3 [/SUP], Zhaohui Chai[SUP] 4 [/SUP], Peidong Zheng[SUP] 4 [/SUP], Qinmiao Sun[SUP] 5 [/SUP], Silan Gu[SUP] 2 [/SUP], Qiaomai Xu[SUP] 2 [/SUP], Haiting Feng[SUP] 6 [/SUP], Lingling Tang[SUP] 7 8 [/SUP]
Affiliations
- PMID: 34563110
- DOI: 10.1186/s12879-021-06485-x
Abstract
Background: Through the comparison of the demographic, epidemiological, and clinical characteristics of hospital human influenza (influenza A (H1N1) pdm09, H3N2, and B)-related and hospitalized avian-origin influenza A (H7N9)-related viral pneumonia patients, find the different between them.
Methods: A retrospective study was conducted in hospitalized influenza-related viral pneumonia patients.
Results: Human influenza A-related patients in the 35-49-year-old group were more than those with B pneumonia patients (p = 0.027), and relatively less in the ≥ 65-year-old group than B pneumonia patients (p = 0.079). The proportion of comorbid condition to human influenza A pneumonia was 58%, lower than B pneumonia and H7N9 pneumonia patients (78% vs. 77.8%; p = 0.013). The proportion of invasive mechanical ventilation (IMV), lymphocytopenia, elevated lactate dehydrogenase to hospitalized human influenza A-related viral pneumonia patients was higher than B pneumonia patients (p < 0.05), but lower than H7N9 pneumonia patients (p < 0.05). In the multivariate analysis, pulmonary consolidation (odds ratio (OR): 13.67; 95% confidence interval (CI) 1.54-121.12; p = 0.019) and positive bacterial culture (sputum) (OR: 7.71; 95% CI 2.48-24.03; p < 0.001) were independently associated with IMV, while shock (OR: 13.16; 95% CI 2.06-84.07; p = 0.006), white blood cell count > 10,000/mm[SUP]3[/SUP] (OR: 7.22; 95% CI 1.47-35.58; p = 0.015) and positive bacterial culture(blood or sputum) (OR: 6.27; 95% CI 1.36-28.85; p = 0.018) were independently associated with death in the three types hospitalized influenza-related viral pneumonia patients.
Conclusions: Hospital influenza B-related viral pneumonia mainly affects the elderly and people with underlying diseases, while human influenza A pneumonia mainly affects the young adults; however, the mortality was similar. The hospitalized human influenza A-related viral pneumonia patients was severer than B pneumonia patients, but milder than H7N9 pneumonia patients. Pulmonary consolidation and positive bacterial culture (sputum) were independently associated with IMV, while shock, white blood cell count > 10,000/mm[SUP]3[/SUP], and positive bacterial culture (blood or sputum) were independently associated with death to three types hospitalized influenza-related viral pneumonia patients.
Keywords: Avian-origin influenza H7N9; Human influenza A; Influenza B; Severe cases; Viral pneumonia.