tetano
Editor, Senior Moderator
BMC Geriatr
. 2020 Nov 30;20(1):514.
doi: 10.1186/s12877-020-01921-0.
Clinical characteristics on admission predict in-hospital fatal outcome in patients aged ≥75 years with novel coronavirus disease (COVID-19): a retrospective cohort study
Zhihua Yu[SUP] 1 2 [/SUP], Yuhe Ke[SUP] 2 [/SUP], Jiang Xie[SUP] 3 [/SUP], Hao Yu[SUP] 2 [/SUP], Wei Zhu[SUP] 2 [/SUP], Liqun He[SUP] 2 [/SUP], Qiongli Zheng[SUP] 2 [/SUP], Chuanwei Li[SUP] 4 [/SUP], Jingya Lu[SUP] 5 [/SUP], Songnan Li[SUP] 1 [/SUP], Songnan Wen[SUP] 1 [/SUP], Sheng Wei[SUP] 5 [/SUP], Nian Liu[SUP] 1 [/SUP], Li Wei[SUP] 2 [/SUP], Rong Bai[SUP] 6 7 8 [/SUP]
Affiliations
Abstract
Background: Novel coronavirus disease 2019 (COVID-19) has become a worldwide pandemic and precise fatality data by age group is needed urgently. This study to delineate the clinical characteristics and outcome of COVID-19 patients aged ≥75 years and identify the risk factors of in-hospital death.
Methods: A total of 141 consecutive patients aged ≥75 years who were admitted to the hospital between 12th and 19th February 2020. In-hospital death, clinical characteristics and laboratory findings on admission were obtained from medical records. The final follow-up observation was on the 31st March 2020.
Results: The median age was 81 years (84 female, 59.6%). Thirty-eight (27%) patients were classified as severe or critical cases. 18 (12.8%) patients had died in hospital and the remaining 123 were discharged. Patients who died were more likely to present with fever (38.9% vs. 7.3%); low percutaneous oxygen saturation (SpO[SUB]2[/SUB]) (55.6% vs. 7.3%); reduced lymphocytes (72.2% vs. 35.8%) and platelets (27.8% vs. 4.1%); and increased D-dimer (94.4% vs. 42.3%), creatinine (50.0% vs. 22.0%), lactic dehydrogenase (LDH) (77.8% vs. 30.1%), high sensitivity troponin I (hs-TnI) (72.2% vs. 14.6%), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (72.2% vs. 6.5%; all P < 0.05) than patients who recovered. Male sex (odds ratio [OR] = 13.1, 95% confidence interval [CI] 1.1 to 160.1, P = 0.044), body temperature > 37.3 ?C (OR = 80.5, 95% CI 4.6 to 1407.6, P = 0.003), SpO[SUB]2[/SUB] ≤ 90% (OR = 70.1, 95% CI 4.6 to 1060.4, P = 0.002), and NT-proBNP> 1800 ng/L (OR = 273.5, 95% CI 14.7 to 5104.8, P < 0.0001) were independent risk factors of in-hospital death.
Conclusions: In-hospital fatality among elderly COVID-19 patients can be estimated by sex and on-admission measurements of body temperature, SpO[SUB]2[/SUB], and NT-proBNP.
Keywords: Coronavirus disease; Death; Elderly; Prediction; SARS-CoV-2.
. 2020 Nov 30;20(1):514.
doi: 10.1186/s12877-020-01921-0.
Clinical characteristics on admission predict in-hospital fatal outcome in patients aged ≥75 years with novel coronavirus disease (COVID-19): a retrospective cohort study
Zhihua Yu[SUP] 1 2 [/SUP], Yuhe Ke[SUP] 2 [/SUP], Jiang Xie[SUP] 3 [/SUP], Hao Yu[SUP] 2 [/SUP], Wei Zhu[SUP] 2 [/SUP], Liqun He[SUP] 2 [/SUP], Qiongli Zheng[SUP] 2 [/SUP], Chuanwei Li[SUP] 4 [/SUP], Jingya Lu[SUP] 5 [/SUP], Songnan Li[SUP] 1 [/SUP], Songnan Wen[SUP] 1 [/SUP], Sheng Wei[SUP] 5 [/SUP], Nian Liu[SUP] 1 [/SUP], Li Wei[SUP] 2 [/SUP], Rong Bai[SUP] 6 7 8 [/SUP]
Affiliations
- PMID: 33256640
- DOI: 10.1186/s12877-020-01921-0
Abstract
Background: Novel coronavirus disease 2019 (COVID-19) has become a worldwide pandemic and precise fatality data by age group is needed urgently. This study to delineate the clinical characteristics and outcome of COVID-19 patients aged ≥75 years and identify the risk factors of in-hospital death.
Methods: A total of 141 consecutive patients aged ≥75 years who were admitted to the hospital between 12th and 19th February 2020. In-hospital death, clinical characteristics and laboratory findings on admission were obtained from medical records. The final follow-up observation was on the 31st March 2020.
Results: The median age was 81 years (84 female, 59.6%). Thirty-eight (27%) patients were classified as severe or critical cases. 18 (12.8%) patients had died in hospital and the remaining 123 were discharged. Patients who died were more likely to present with fever (38.9% vs. 7.3%); low percutaneous oxygen saturation (SpO[SUB]2[/SUB]) (55.6% vs. 7.3%); reduced lymphocytes (72.2% vs. 35.8%) and platelets (27.8% vs. 4.1%); and increased D-dimer (94.4% vs. 42.3%), creatinine (50.0% vs. 22.0%), lactic dehydrogenase (LDH) (77.8% vs. 30.1%), high sensitivity troponin I (hs-TnI) (72.2% vs. 14.6%), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (72.2% vs. 6.5%; all P < 0.05) than patients who recovered. Male sex (odds ratio [OR] = 13.1, 95% confidence interval [CI] 1.1 to 160.1, P = 0.044), body temperature > 37.3 ?C (OR = 80.5, 95% CI 4.6 to 1407.6, P = 0.003), SpO[SUB]2[/SUB] ≤ 90% (OR = 70.1, 95% CI 4.6 to 1060.4, P = 0.002), and NT-proBNP> 1800 ng/L (OR = 273.5, 95% CI 14.7 to 5104.8, P < 0.0001) were independent risk factors of in-hospital death.
Conclusions: In-hospital fatality among elderly COVID-19 patients can be estimated by sex and on-admission measurements of body temperature, SpO[SUB]2[/SUB], and NT-proBNP.
Keywords: Coronavirus disease; Death; Elderly; Prediction; SARS-CoV-2.