tetano
Editor, Senior Moderator
BMC Cardiovasc Disord
. 2020 Nov 10;20(1):479.
doi: 10.1186/s12872-020-01758-w.
Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19)
Jing Li[SUP] 1 [/SUP], Yinghua Zhang[SUP] 2 [/SUP], Fang Wang[SUP] 3 [/SUP], Bing Liu[SUP] 3 [/SUP], Hui Li[SUP] 3 [/SUP], Guodong Tang[SUP] 3 [/SUP], Zhigang Chang[SUP] 4 [/SUP], Aihua Liu[SUP] 5 [/SUP], Chunyi Fu[SUP] 6 [/SUP], You Lv[SUP] 3 [/SUP], Jing Gao[SUP] 7 [/SUP], Jing Li[SUP] 8 9 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic. Studies showed COVID-19 affected not only the lung but also other organs. In this study, we aimed to explore the cardiac damage in patients with COVID-19.
Methods: We collected data of 100 patients diagnosed as severe type of COVID-19 from February 8 to April 10, 2020, including demographics, illness history, physical examination, laboratory test, and treatment. In-hospital mortality were observed. Cardiac damage was defined as plasma hypersensitive troponin I (hsTnI) over 34.2 pg/ml and/or N-terminal-pro brain natriuretic peptide (NTproBNP) above 450 pg/ml at the age < 50, above 900 pg/ml at the age < 75, or above 1800 pg/ml at the age ≥ 75.
Results: The median age of the patients was 62.0 years old. 69 (69.0%) had comorbidities, mainly presenting hypertension, diabetes, and cardiovascular disease. Fever (69 [69.0%]), cough (63 [63.0%]), chest distress (13 [13.0%]), and fatigue (12 [12.0%]) were the common initial symptoms. Cardiac damage occurred in 25 patients. In the subgroups, hsTnI was significantly higher in elder patients (≥ 60 years) than in the young (median [IQR], 5.2 [2.2-12.8] vs. 1.9 [1.9-6.2], p = 0.018) and was higher in men than in women (4.2 [1.9-12.8] vs. 2.9 [1.9-7.4], p = 0.018). The prevalence of increased NTproBNP was significantly higher in men than in women (32.1% vs. 9.1%, p = 0.006), but was similar between the elder and young patients (20.0% vs. 25.0%, p = 0.554). After multivariable analysis, male and hypertension were the risk factors of cardiac damage. The mortality was 4.0%.
Conclusions: Cardiac damage exists in patients with the severe type of COVID-19, especially in male patients with hypertension. Clinicians should pay more attention to cardiac damage.
Keywords: Cardiac damage; Coronavirus; Severe pneumonia.
. 2020 Nov 10;20(1):479.
doi: 10.1186/s12872-020-01758-w.
Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19)
Jing Li[SUP] 1 [/SUP], Yinghua Zhang[SUP] 2 [/SUP], Fang Wang[SUP] 3 [/SUP], Bing Liu[SUP] 3 [/SUP], Hui Li[SUP] 3 [/SUP], Guodong Tang[SUP] 3 [/SUP], Zhigang Chang[SUP] 4 [/SUP], Aihua Liu[SUP] 5 [/SUP], Chunyi Fu[SUP] 6 [/SUP], You Lv[SUP] 3 [/SUP], Jing Gao[SUP] 7 [/SUP], Jing Li[SUP] 8 9 [/SUP]
Affiliations
- PMID: 33167876
- DOI: 10.1186/s12872-020-01758-w
Abstract
Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic. Studies showed COVID-19 affected not only the lung but also other organs. In this study, we aimed to explore the cardiac damage in patients with COVID-19.
Methods: We collected data of 100 patients diagnosed as severe type of COVID-19 from February 8 to April 10, 2020, including demographics, illness history, physical examination, laboratory test, and treatment. In-hospital mortality were observed. Cardiac damage was defined as plasma hypersensitive troponin I (hsTnI) over 34.2 pg/ml and/or N-terminal-pro brain natriuretic peptide (NTproBNP) above 450 pg/ml at the age < 50, above 900 pg/ml at the age < 75, or above 1800 pg/ml at the age ≥ 75.
Results: The median age of the patients was 62.0 years old. 69 (69.0%) had comorbidities, mainly presenting hypertension, diabetes, and cardiovascular disease. Fever (69 [69.0%]), cough (63 [63.0%]), chest distress (13 [13.0%]), and fatigue (12 [12.0%]) were the common initial symptoms. Cardiac damage occurred in 25 patients. In the subgroups, hsTnI was significantly higher in elder patients (≥ 60 years) than in the young (median [IQR], 5.2 [2.2-12.8] vs. 1.9 [1.9-6.2], p = 0.018) and was higher in men than in women (4.2 [1.9-12.8] vs. 2.9 [1.9-7.4], p = 0.018). The prevalence of increased NTproBNP was significantly higher in men than in women (32.1% vs. 9.1%, p = 0.006), but was similar between the elder and young patients (20.0% vs. 25.0%, p = 0.554). After multivariable analysis, male and hypertension were the risk factors of cardiac damage. The mortality was 4.0%.
Conclusions: Cardiac damage exists in patients with the severe type of COVID-19, especially in male patients with hypertension. Clinicians should pay more attention to cardiac damage.
Keywords: Cardiac damage; Coronavirus; Severe pneumonia.