tetano
Editor, Senior Moderator
BMB Rep
. 2020 Jul 31;5079.
Online ahead of print.
Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment
Kaavya Jayaramayya, Iyer Mahalaxmi, Mohana Devi Subramaniam, Neethu Raj, Ahmed Abdal Dayem, Kyung Min Lim, Se Jong Kim, Jong Yub An, Yoonjoo Lee, Yujin Choi, Arthi Kirubhakaran, Ssang-Goo Cho[SUP] 1 [/SUP], Balachandar Vellingiri[SUP] 2 [/SUP]
Affiliations
Abstract
The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Sincethe immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The useof stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSC-Exos have immunomodulatory functions; theycan be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19.
. 2020 Jul 31;5079.
Online ahead of print.
Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment
Kaavya Jayaramayya, Iyer Mahalaxmi, Mohana Devi Subramaniam, Neethu Raj, Ahmed Abdal Dayem, Kyung Min Lim, Se Jong Kim, Jong Yub An, Yoonjoo Lee, Yujin Choi, Arthi Kirubhakaran, Ssang-Goo Cho[SUP] 1 [/SUP], Balachandar Vellingiri[SUP] 2 [/SUP]
Affiliations
- PMID: 32731913
Abstract
The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Sincethe immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The useof stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSC-Exos have immunomodulatory functions; theycan be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19.