tetano
Editor, Senior Moderator
Blood Coagul Fibrinolysis
. 2021 Jan 12.
doi: 10.1097/MBC.0000000000001007. Online ahead of print.
Vascular activation is a strong predictor of mortality in coronavirus disease 2019 patients on the ICU
Raf De Jongh[SUP] 1 [/SUP], Marisa Ninivaggi, Dieter Mesotten, Cui Bai, Berend Marcus, Dana Huskens, Hendrik Stragier, Adam Miszta, Jasmine Verbruggen, Romy M W de Laat-Kremers, Jef Grieten, Bas de Laat
Affiliations
Abstract
Respiratory failure in coronavirus disease 2019 (COVID-19) patients is one of the most frequent causes for referral to the ICU. A significant percentage of these patients does not survive the infection due to thromboembolic complications. Furthermore, the vascular system seems also to be involved in the pathogenesis. To investigate the role of hemostasis and endothelium on the outcome of COVID-19 patients admitted to the ICU. Blood was drawn from 16 ICU COVID-19 patients for hemostatic analysis. Patients were followed-up till discharge (n = 11) or death (n = 5). Parameters related to both coagulation and fibrinolysis, though disturbed, were not associated with mortality. Contrarily, activated Von Willebrand factor was increased and ADAMTS13 levels were decreased by two-fold in nonsurvivors compared with survivors. Our data established the involvement of the Von Willebrand factor-ADAMTS13 axis in the COVID-19 pathogenesis, thereby demonstrating that these plasma proteins seem to be strong predictors for ICU mortality.
. 2021 Jan 12.
doi: 10.1097/MBC.0000000000001007. Online ahead of print.
Vascular activation is a strong predictor of mortality in coronavirus disease 2019 patients on the ICU
Raf De Jongh[SUP] 1 [/SUP], Marisa Ninivaggi, Dieter Mesotten, Cui Bai, Berend Marcus, Dana Huskens, Hendrik Stragier, Adam Miszta, Jasmine Verbruggen, Romy M W de Laat-Kremers, Jef Grieten, Bas de Laat
Affiliations
- PMID: 33443932
- DOI: 10.1097/MBC.0000000000001007
Abstract
Respiratory failure in coronavirus disease 2019 (COVID-19) patients is one of the most frequent causes for referral to the ICU. A significant percentage of these patients does not survive the infection due to thromboembolic complications. Furthermore, the vascular system seems also to be involved in the pathogenesis. To investigate the role of hemostasis and endothelium on the outcome of COVID-19 patients admitted to the ICU. Blood was drawn from 16 ICU COVID-19 patients for hemostatic analysis. Patients were followed-up till discharge (n = 11) or death (n = 5). Parameters related to both coagulation and fibrinolysis, though disturbed, were not associated with mortality. Contrarily, activated Von Willebrand factor was increased and ADAMTS13 levels were decreased by two-fold in nonsurvivors compared with survivors. Our data established the involvement of the Von Willebrand factor-ADAMTS13 axis in the COVID-19 pathogenesis, thereby demonstrating that these plasma proteins seem to be strong predictors for ICU mortality.