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Blocking of Exchange Proteins Directly Activated by cAMP (Epac) Leads to Reduced Replication of Middle East Respiratory Syndrome-Coronavirus

Shannon Bennett

Shannon Bennett

Well-known member
Blocking of Exchange Proteins Directly Activated by cAMP (Epac) Leads to Reduced Replication of Middle East Respiratory Syndrome-Coronavirus


  1. Xinrong Tao1,
  2. Feng Mei2,
  3. Anurodh Agrawal1,
  4. Clarence J. Peters1,3,5,6,
  5. Thomas G. Ksiazek3,4,5,6,
  6. Xiaodong Cheng2* and
  7. Chien-Te K. Tseng1,3,5,6*
+ Author Affiliations

  1. <ADDRESS>Departments of Microbiology and Immunology<SUP>1</SUP></ADDRESS>
  2. <ADDRESS>Pharmacology and Toxicology<SUP>2</SUP></ADDRESS>
  3. <ADDRESS>Center for Biodefense and Emerging Infectious Disease<SUP>3</SUP></ADDRESS>
  4. <ADDRESS>Pathology<SUP>4</SUP></ADDRESS>
  5. <ADDRESS>Sealy Center for Vaccine Development<SUP>5</SUP></ADDRESS>
  6. <ADDRESS>Center for Tropical Diseases<SUP>6</SUP>, University of Texas Medical Branch, Galveston, Texas, 77555 </ADDRESS>

ABSTRACT

The outbreak of MERS-CoV infection and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cAMP-1 (Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection.

http://jvi.asm.org/content/early/2013/12/20/JVI.03001-13.short
 
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