tetano
Editor, Senior Moderator
BJOG. 2020 May 5. doi: 10.1111/1471-0528.16276. [Epub ahead of print]
Coronavirus disease 2019 among pregnant Chinese women: Case series data on the safety of vaginal birth and breastfeeding.
Wu Y[SUP]1[/SUP], Liu C[SUP]2[/SUP], Dong L[SUP]3[/SUP], Zhang C[SUP]1[/SUP], Chen Y[SUP]4[/SUP], Liu J[SUP]3,[/SUP][SUP]4[/SUP], Zhang C[SUP]1[/SUP], Duan C[SUP]1[/SUP], Zhang H[SUP]1[/SUP], Mol BW[SUP]5[/SUP], Dennis CL[SUP]6[/SUP], Yin T[SUP]3[/SUP], Yang J[SUP]3[/SUP], Huang H[SUP]1[/SUP].
Author information
Abstract
OBJECTIVE:
To assess whether vaginal secretions and breast milk of COVID-19 patients contain SARS-CoV-2 virus.
DESIGN:
Single center cohort study.
SETTING:
Renmin Hospital of Wuhan University, Wuhan, Hubei province, China.
POPULATION OR SAMPLE:
We studied 13 COVID-19 infected pregnant women diagnosed between January 31 and March 9, 2020.
METHODS:
We collected clinical data, vaginal secretions and stool specimens, breast milk from COVID-19 infected women during different stages of pregnancy and neonatal throat, anal swabs.
MAIN OUTCOME(S) AND MEASURE(S):
We assessed viral presence in different biosamples.
RESULTS:
Of the 13 women with COVID-19, 5 were in their first trimester, 3 in their second trimester, and 5 in their third trimester. Of the 5 women during their third trimester who gave birth, all delivered live newborns. Among these 5 deliveries, the primary adverse perinatal outcomes included premature delivery (n = 2) and neonatal pneumonia (n = 2). One of 9 stool samples was positive; and all 13 vaginal secretion samples, and 5 throat swabs and 4 anal swabs collected from newborns were negative for the novel coronavirus. However, 1 of 3 samples of breast milk was positive by viral nucleic acid testing.
CONCLUSIONS:
In this case series of 13 pregnant women with COVID-19, we observed negative viral test results in vaginal secretion specimens, suggesting that a vaginal delivery may be a safe delivery option. However, additional research is urgently needed to examine breast milk and the potential risk for viral contamination.
This article is protected by copyright. All rights reserved.
KEYWORDS:
COVID-19; breast milk; vaginal secretions
PMID:32369656DOI:10.1111/1471-0528.16276
Coronavirus disease 2019 among pregnant Chinese women: Case series data on the safety of vaginal birth and breastfeeding.
Wu Y[SUP]1[/SUP], Liu C[SUP]2[/SUP], Dong L[SUP]3[/SUP], Zhang C[SUP]1[/SUP], Chen Y[SUP]4[/SUP], Liu J[SUP]3,[/SUP][SUP]4[/SUP], Zhang C[SUP]1[/SUP], Duan C[SUP]1[/SUP], Zhang H[SUP]1[/SUP], Mol BW[SUP]5[/SUP], Dennis CL[SUP]6[/SUP], Yin T[SUP]3[/SUP], Yang J[SUP]3[/SUP], Huang H[SUP]1[/SUP].
Author information
Abstract
OBJECTIVE:
To assess whether vaginal secretions and breast milk of COVID-19 patients contain SARS-CoV-2 virus.
DESIGN:
Single center cohort study.
SETTING:
Renmin Hospital of Wuhan University, Wuhan, Hubei province, China.
POPULATION OR SAMPLE:
We studied 13 COVID-19 infected pregnant women diagnosed between January 31 and March 9, 2020.
METHODS:
We collected clinical data, vaginal secretions and stool specimens, breast milk from COVID-19 infected women during different stages of pregnancy and neonatal throat, anal swabs.
MAIN OUTCOME(S) AND MEASURE(S):
We assessed viral presence in different biosamples.
RESULTS:
Of the 13 women with COVID-19, 5 were in their first trimester, 3 in their second trimester, and 5 in their third trimester. Of the 5 women during their third trimester who gave birth, all delivered live newborns. Among these 5 deliveries, the primary adverse perinatal outcomes included premature delivery (n = 2) and neonatal pneumonia (n = 2). One of 9 stool samples was positive; and all 13 vaginal secretion samples, and 5 throat swabs and 4 anal swabs collected from newborns were negative for the novel coronavirus. However, 1 of 3 samples of breast milk was positive by viral nucleic acid testing.
CONCLUSIONS:
In this case series of 13 pregnant women with COVID-19, we observed negative viral test results in vaginal secretion specimens, suggesting that a vaginal delivery may be a safe delivery option. However, additional research is urgently needed to examine breast milk and the potential risk for viral contamination.
This article is protected by copyright. All rights reserved.
KEYWORDS:
COVID-19; breast milk; vaginal secretions
PMID:32369656DOI:10.1111/1471-0528.16276