Mary Wilson
Well-known member
Published: 06 June 2023
https://doi.org/10.1093/infdis/jiad111
Wei Wang, Emilie Goguet, Stephanie Paz Padilla, Russell Vassell, Simon Pollett, Edward Mitre, Carol D Weiss
Abstract
We compared neutralizing antibody responses to BA.4/5, BQ.1.1, XBB, and XBB.1.5 Omicron SARS-CoV-2 variants after a bivalent or ancestral COVID-19 mRNA booster vaccine or post-vaccination infection. We found that the bivalent booster elicited moderately high antibody titers against BA.4/5 that were approximately two-fold higher against all Omicron variants than titers elicited by the monovalent booster. The bivalent booster elicited low but similar titers against both XBB and XBB.1.5 variants. These findings inform risk assessments for future COVID-19 vaccine recommendations and suggest that updated COVID-19 vaccines containing matched vaccine antigens to circulating divergent variants may be needed.
https://watermark.silverchair.com/j...6Ma3NetTN7d38AAUxEeQ59N5uncluHibOSr--F-LDCrb4
https://doi.org/10.1093/infdis/jiad111
Wei Wang, Emilie Goguet, Stephanie Paz Padilla, Russell Vassell, Simon Pollett, Edward Mitre, Carol D Weiss
Abstract
We compared neutralizing antibody responses to BA.4/5, BQ.1.1, XBB, and XBB.1.5 Omicron SARS-CoV-2 variants after a bivalent or ancestral COVID-19 mRNA booster vaccine or post-vaccination infection. We found that the bivalent booster elicited moderately high antibody titers against BA.4/5 that were approximately two-fold higher against all Omicron variants than titers elicited by the monovalent booster. The bivalent booster elicited low but similar titers against both XBB and XBB.1.5 variants. These findings inform risk assessments for future COVID-19 vaccine recommendations and suggest that updated COVID-19 vaccines containing matched vaccine antigens to circulating divergent variants may be needed.
https://watermark.silverchair.com/j...6Ma3NetTN7d38AAUxEeQ59N5uncluHibOSr--F-LDCrb4