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Bird flu virus strain in Vietnam mutates

AlaskaDenise

AlaskaDenise

In Memoriam
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2007-10-10 12:32:40 </TD><TD class=hui12 align=middle width="26%"> </TD><TD class=hui12 align=middle width="12%">http://news.xinhuanet.com/english/2007-10/10/content_6857409.htm#
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HANOI, Oct. 10 (Xinhua) -- Bird flu virus strain in Vietnam has mutated, becoming more dangerous, local newspaper Pioneer reported Wednesday.

However, the mutation is not big enough for the virus to transmit among humans, the paper quoted Vietnamese Minister of Agriculture and Rural Development Cao Duc Phat as saying at a meeting of the country's Anti-bird flu Central Steering Committee on Tuesday.

The vaccination among poultry is still effective in preventing the disease due to the high compatibly between the vaccine and the virus, he said.

Vietnam is encountering high risk of bird flu reoccurrence late this year, when cold weather condition is more favorable for the development of viruses, he said.

The minister has asked local relevant agencies to focus on intensifying disease surveillance, monitoring of poultry raising, transporting and trading, and vaccination among fowls nationwide.

Vietnam has detected seven bird flu patients from the five northern provinces of Vinh Phuc, Thai Nguyen, Thanh Hoa, Ha Nam and Ha Tay since May 10, of whom four died, according to the Preventive Medicine Department under the Vietnamese Health Ministry. Bird flu outbreaks in Vietnam, starting in December 2003, have killed and led to the forced culling of dozens of millions of fowls in the country, according to the Department of Animal Health under the Ministry of Agriculture and Rural Development.

http://news.xinhuanet.com/english/2007-10/10/content_6857409.htm

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Re: Bird flu virus strain in Vietnam mutates

could be just another version about the recent Kawaoka paper,
and the mutation was E627K(PB2) from 2004 ?
 
Re: Bird flu virus strain in Vietnam mutates

gsgs said:
could be just another version about the recent Kawaoka paper,
and the mutation was E627K(PB2) from 2004 ?
Click to expand...

Could be, however this article is referring just to Vietnam & the PB2/627 mutation is not new. I've read papers about it dated 1993.

.
 
Re: Bird flu virus strain in Vietnam mutates

gsgs said:
could be just another version about the recent Kawaoka paper,
and the mutation was E627K(PB2) from 2004 ?
Click to expand...
Please. E627K is in Qinghai. Human H5N1 with E627K go back to 1997 in Hong Kong.
 
Re: Bird flu virus strain in Vietnam mutates

I mean, the Kawaoka paper was mainly about E627K tested in mice
with strains
A/Vietnam/1203/2004(H5N1)
and
A/Vietnam/1204/2004(H5N1)

so, that could be why Xinhua speaks about the Vietnam mutation
 
Re: Bird flu virus strain in Vietnam mutates

niman said:
Please. E627K is in Qinghai. Human H5N1 with E627K go back to 1997 in Hong Kong.
Click to expand...

The resultant bird deaths at Qinghai (Spring 2005) vs. the same species that survived, says what about E627K? Did those birds who died have the strain with 627 set to avian, while those birds who lived have the strain with 627 set to mammalian?

.
 
Re: Bird flu virus strain in Vietnam mutates

gsgs said:
I mean, the Kawaoka paper was mainly about E627K tested in mice
with strains
A/Vietnam/1203/2004(H5N1)
and
A/Vietnam/1204/2004(H5N1)

so, that could be why Xinhua speaks about the Vietnam mutation
Click to expand...

The ariticle says "...in Vietnam..." while I would presume Kawaoka mice were "...in the lab..." Now whether it was his lab in Tokyo or Wisconsin, I don't know. :D

.
 
Re: Bird flu virus strain in Vietnam mutates

AlaskaDenise said:
The resultant bird deaths at Qinghai (Spring 2005) vs. the same species that survived, says what about E627K? Did those birds who died have the strain with 627 set to avian, while those birds who lived have the strain with 627 set to mammalian?

.
Click to expand...
Although waterfowl do better with H5N1 than terrestrial birds, virtually all Qinghai H5N1 has E627K, including dead and dying waterfowl.
 
Re: Bird flu virus strain in Vietnam mutates

gsgs said:
I mean, the Kawaoka paper was mainly about E627K tested in mice
with strains
A/Vietnam/1203/2004(H5N1)
and
A/Vietnam/1204/2004(H5N1)

so, that could be why Xinhua speaks about the Vietnam mutation
Click to expand...
No, the E627K in human cases has been a concern since 1997. It has been known since 2004 that it was alos in a large subset of human cases in Vietnam and Thailand (and Indonesia),

Contrary to message board postings, there distinction between bird and human PB2 has been known for years and has been VERY obvious. All seasonal flu (going back to 1918) has E627K.
 
Re: Bird flu virus strain in Vietnam mutates

gsgs said:
I mean, the Kawaoka paper was mainly about E627K tested in mice
with strains
A/Vietnam/1203/2004(H5N1)
and
A/Vietnam/1204/2004(H5N1)

so, that could be why Xinhua speaks about the Vietnam mutation
Click to expand...
The change is from Clade 1 to Clade 2.3 (Fujian). The 2007 bird isolates from Vietnam were Fujian, which has nothing to do with PB2 E627K..
 
Re: Bird flu virus strain in Vietnam mutates

AlaskaDenise said:
The ariticle says "...in Vietnam..." while I would presume Kawaoka mice were "...in the lab..." Now whether it was his lab in Tokyo or Wisconsin, I don't know. :D

.
Click to expand...
The Vietnam isolates have been around since 2004. Kawaoka uses them in his lab. He has been focused on E627K for some time (and has previously demonstrated increased virulence in mice using H5N1 from Hong Kong in 1997).

This thread however is on Fujian (clade 2.3) moving into Vietnam and cross reactivity with bird vaccines, which is why Vietnam wants vaccine from China, where Fujian is widespread, especially in southern China, which borders Vietnam.
 
Re: Bird flu virus strain in Vietnam mutates

gsgs said:
could be just another version about the recent Kawaoka paper,
and the mutation was E627K(PB2) from 2004 ?
Click to expand...
Here is a brief summary of Fujian (clade 2.3). It is characterized by a missing amino acid in the HA cleavage site. Instead of RERRRKKR it has RERRRKR (one of the K's was dropped). The dropped K goes back to one of the first H5N1 genotype Z sequences (from ducks smuggled into Taiwan from Fujian province) in late 2003. The Fujian (clade 2.3) was first isolated in mid-2005 from Fujian province. The PNAS paper by Hong Kong described the spread throughout southern China. The Fujian strain was subsequently detected in Laos and Malaysia in early 2006.

The PNAS paper speculated that the Fujian strain was a "third wave" and woudl replace Qinghai, which had spread to all countries west of China. The "third wave" had no scientific basis because Fujian has never been reported outside of China and southeastern Asia (other than exotic birds from Taiwan quarantined in England in early 2006).

Fijian was reported in Thailand in early 2007 and the recent bird sequences from Vietnam from 2007 show that Fujian has also moved in Vietnam.

Since earlier isokates from Vietnam were clade 1, there was concern that the vaccine for clade 1 would not provide protection for clade 2.3 (Fujian). The new "mutation" in Vietnam is the detection of the Fujian strain, which was expected since Fujian had already moved into Laos, Malaysia, and Thailand (from southern China) in 2006 and early 2007.
 
Re: Bird flu virus strain in Vietnam mutates

OK, so it has nothing to do with Kawaoke
and Xinhua should have said "changed" , not "mutated"

these press releases about "mutations" are worrying and sometimes
misleading.
 
Re: Bird flu virus strain in Vietnam mutates

Thanks for the clarification.

Is there any particular reason why clade 2.3 would move in and possibly replace clade 1?

niman said:
....... there was concern that the vaccine for clade 1 would not provide protection for clade 2.3 (Fujian). .......
Click to expand...

What have been the results with dissimilar vaccines in the past?

How does this compare to the use of human prepandemic (?dissimilar) vaccines?

.
 
Re: Bird flu virus strain in Vietnam mutates

AlaskaDenise said:
Thanks for the clarification.

Is there any particular reason why clade 2.3 would move in and possibly replace clade 1?



What have been the results with dissimilar vaccines in the past?

How does this compare to the use of human prepandemic (?dissimilar) vaccines?

.
Click to expand...
There was some speculation that Fujian became dominant in southern China because of a poor match with vaccines in use. Spread to southeast Asia is not a surprise because of proximity.

On the human vaccine front, the first vaccine against the Z gentotype was directed against clade 1 from a case in Vietnam (2004). At the time, all human cases were clade 1 in Vietnam and Thailand. However, when clade 2.1 was identified in human in Indonesia, the first confirmed case in Indoensia was added to the pandemic vaccine target list. The same thing happened when Clade 2.3 (Fujian) was discovered in China in 2005. Clade 2.2 (Qinghai) became a target when it was found in wild birds in 2005 also. Qinghai was subsequently found in patients in Turkey, Iraq, Egypt, Azerbaijan. Djibouti, and Nigeria, although the vaccine targets are wild bird isolates.

Although the vaccine cross protect to a degree, the titers are highest against the immunizing target. Each of the clades is evolving, although new polymorphisms jump from clade to clade because of recombination.
 
Re: Bird flu virus strain in Vietnam mutates

> new polymorphisms jump from clade to clade because of recombination.

no,no,no.

strains are clearly separated in time and space and phylogeny.
Very little intermixing.
No "intermediate" strains, just Fujian,VNM.
 
Re: Bird flu virus strain in Vietnam mutates

gsgs said:
> new polymorphisms jump from clade to clade because of recombination.

no,no,no.

strains are clearly separated in time and space and phylogeny.
Very little intermixing.
No "intermediate" strains, just Fujian,VNM.
Click to expand...
Please. The jumping is VERY obvious (clade 1 in 2004 had new cleavage site in 2005, which matched China).

Please stop posting misleading information.
 
Re: Bird flu virus strain in Vietnam mutates

gsgs said:
OK, so it has nothing to do with Kawaoke
and Xinhua should have said "changed" , not "mutated"

these press releases about "mutations" are worrying and sometimes
misleading.
Click to expand...
Popular press stories on genetic are always dumbed down. Those in the field have no problem understanding the story. Fujian was reported in China in 2005. Movement to southeast Asia in 2006 (including Laos and Malaysia). 2007 sequences from Vietnam were posted last week (and from Thailand earlier this year)

http://www.flutrackers.com/forum/showthread.php?t=37157
 
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