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Bird flu pandemic is inevitable, expert says after new outbreak

Treyfish

Moderator
From The Times
May 25, 2007


Bird flu pandemic is inevitable, expert says after new outbreak



<!-- END: Module - Main Heading --><!--CMA user Call Diffrenet Variation Of Image --><!-- BEGIN: Module - M24 Article Headline with no image (a) --><!-- getting the section url from article. This has been done so that correct url isgenerated if we are coming from a section or topic --><!-- Print Author name associated with the article --><!-- Print Author name from By Line associated with the article -->Melanie Reid


<!-- END: Module - M24 Article Headline with no image --><!-- Article Copy module --><!-- BEGIN: Module - Main Article --><!-- Check the Article Type and display accordingly--><!-- Print Author image associated with the Author--><!-- Print the body of the article--><!-- Pagination -->The director of Britain?s new centre for avian flu research said yesterday that it was a question of ?not if but when? the disease would cause a pandemic.
Professor Tony Nash was speaking on the day that an outbreak of the flu was confirmed on a farm in North Wales, the third incidence in Britain. Professor Nash heads a ?4.3 million research hub at the University of Edinburgh that will be at the forefront of global efforts to combat the growing threat to health.
The chief vet of Wales has confirmed that the death of 15 chickens on a farm in Conwy was caused by a less virulent strain of avian flu ? H7N2 as opposed to H5N1. Two adults associated with the farm have shown flu symptoms and are being treated as a precaution.
The source of the infection is being investigated and a one-kilometre restriction zone is in force around the small farm. Officials said that the strain of the disease presented a low risk to humans.
<!--#include file="m63-article-related-attachements.html"-->Professor Nash said: ?There were three flu pandemics in the 20th century, and we are somewhat overdue for another.?
The new research centre, the first of its kind in Britain, intends to develop new drugs against avian flu. By drawing together experts from the universities of Edinburgh, Glasgow and St Andrews, it hopes to plot the spread of the disease and explore its causes.
In February 159,000 birds were slaughtered on a Suffolk farm belonging to Bernard Matthews after the H5N1 virus was discovered.In April 2006, a dead swan was found on the slipway of the harbour at Cellardyke in Fife. It was the first incidence of H5N1 in Britain and was an isolated case.
The new Interdisciplinary Centre for Human and Avian Influenza Research, which has received ?2 million from the Scottish Funding Council and ?2.3 million from the collaborating universities, will open officially on September 1.
One of the scientists? most important tasks will be to develop a range of ?novel? antivirals (which can block virus replication) and construct a new generation of flu vaccines.
As well as seeking to tackle avian flu, biologists, virologists and epidemiologists will also work together on new treatments for human flu.
Professor Nash said: ?This new centre will be unique in terms of influenza research with a variety of specialists working together with a common aim. Our ultimate hope is that we can achieve new ways of predicting and controlling major flu outbreaks, as well as discovering new therapies that quickly translate into products for humans and animals.?
Vaccines against H5N1 are still in the experimental stage and there are no published studies showing them to be effective.:tiphat: http://www.timesonline.co.uk/tol/news/uk/health/article1838562.ece
<!-- End of pagination -->
 
Re: Bird flu pandemic is inevitable, expert says after new outbreak

if the danger were as big as he wants to make us think, then they would
invest more than 6e6$.
Is another Cholera pandemic also "not if but when" ?
Is the flu-danger currently larger than it was 20 years ago ?

Many published studies show H5N1-vaccines to be effective
in birds and ferrets, see below for ferrets.
Unfortunately we can't so well test it in humans
for ethical reasons.




1: Lipatov AS, Hoffmann E, Salomon R, Yen HL, Webster RG.Related Articles, Links
Cross-protectiveness and immunogenicity of influenza A/Duck/Singapore/3/97(H5) vaccines against infection with A/Vietnam/1203/04(H5N1) virus in ferrets.
J Infect Dis. 2006 Oct 15;194(8):1040-3. Epub 2006 Sep 12.
PMID: 16991078 [PubMed - indexed for MEDLINE]
2: Suguitan AL Jr, McAuliffe J, Mills KL, Jin H, Duke G, Lu B, Luke CJ, Murphy B, Swayne DE, Kemble G, Subbarao K.Related Articles, Links
Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets.
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3: Govorkova EA, Webby RJ, Humberd J, Seiler JP, Webster RG.Related Articles, Links
Immunization with reverse-genetics-produced H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge.
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4: Hampson AW.Related Articles, Links
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5: Webster RG, Peiris M, Chen H, Guan Y.Related Articles, Links
H5N1 outbreaks and enzootic influenza.
Emerg Infect Dis. 2006 Jan;12(1):3-8.
PMID: 16494709 [PubMed - indexed for MEDLINE]
6: Hoffmann E, Lipatov AS, Webby RJ, Govorkova EA, Webster RG.Related Articles, Links
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PMID: 16118277 [PubMed - indexed for MEDLINE]
7: Fan J, Liang X, Horton MS, Perry HC, Citron MP, Heidecker GJ, Fu TM, Joyce J, Przysiecki CT, Keller PM, Garsky VM, Ionescu R, Rippeon Y, Shi L, Chastain MA, Condra JH, Davies ME, Liao J, Emini EA, Shiver JW.Related Articles, Links
Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys.
Vaccine. 2004 Aug 13;22(23-24):2993-3003.
PMID: 15297047 [PubMed - indexed for MEDLINE]
8: Webby RJ, Perez DR, Coleman JS, Guan Y, Knight JH, Govorkova EA, McClain-Moss LR, Peiris JS, Rehg JE, Tuomanen EI, Webster RG.Related Articles, Links
Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines.
Lancet. 2004 Apr 3;363(9415):1099-103.
PMID: 15064027 [PubMed - indexed for MEDLINE]
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Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics.
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10: Subbarao K, Chen H, Swayne D, Mingay L, Fodor E, Brownlee G, Xu X, Lu X, Katz J, Cox N, Matsuoka Y.Related Articles, Links
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11: Wood JM, Major D, Daly J, Newman RW, Dunleavy U, Nicolson C, Robertson JS, Schild GC, Lee-Lin YN.Related Articles, Links
Vaccines against H5N1 influenza.
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12: Li S, Liu C, Klimov A, Subbarao K, Perdue ML, Mo D, Ji Y, Woods L, Hietala S, Bryant M.Related Articles, Links
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