tetano
Editor, Senior Moderator
Biosaf Health
. 2022 May 12.
doi: 10.1016/j.bsheal.2022.04.006. Online ahead of print.
Genomic characteristics of SARS-CoV-2 in Beijing, 2021
Zhaomin Feng[SUP] 1 [/SUP], Shujuan Cui[SUP] 1 [/SUP], Bing Lyu[SUP] 1 [/SUP], Zhichao Liang[SUP] 1 [/SUP], Fu Li[SUP] 1 [/SUP], Lingyu Shen[SUP] 1 [/SUP], Hui Xu[SUP] 1 [/SUP], Peng Yang[SUP] 1 [/SUP], Quanyi Wang[SUP] 1 [/SUP], Daitao Zhang[SUP] 1 [/SUP], Yang Pan[SUP] 1 [/SUP]
Affiliations
Abstract
At present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, which has emerged multiple variants and brought a global threat to public health. To analyze the genomic characteristics and variations of SARS-CoV-2 imported in Beijing, we collected the respiratory tract specimens of 112 cases of coronavirus disease 2019 (COVID-19) from January to September 2021 in Beijing, including 40 local cases and 72 imported cases. The whole-genome sequences of the viruses were sequenced by the next-generation sequencing method. Variant markers and phylogenic features of SARS-CoV-2 were analyzed. Our results showed that in all 112 sequences, the mutations were concentrated in spike protein. D614G was found in all sequences, and mutations including L452R, T478K, P681R/H, and D950N in some cases. Furthermore, 112 sequences belonged to 23 lineages by phylogenetic analysis. B.1.1.7 (Alpha) and B.1.617.2 (Delta) lineages were dominant. Our study drew a variation image of SARS-CoV-2 and could help evaluate the potential risk of COVID-19 for pandemic preparedness and response.
Keywords: Genome; Phylogenetic analysis; Severe acute respiratory syndrome coronavirus 2; Variation.
. 2022 May 12.
doi: 10.1016/j.bsheal.2022.04.006. Online ahead of print.
Genomic characteristics of SARS-CoV-2 in Beijing, 2021
Zhaomin Feng[SUP] 1 [/SUP], Shujuan Cui[SUP] 1 [/SUP], Bing Lyu[SUP] 1 [/SUP], Zhichao Liang[SUP] 1 [/SUP], Fu Li[SUP] 1 [/SUP], Lingyu Shen[SUP] 1 [/SUP], Hui Xu[SUP] 1 [/SUP], Peng Yang[SUP] 1 [/SUP], Quanyi Wang[SUP] 1 [/SUP], Daitao Zhang[SUP] 1 [/SUP], Yang Pan[SUP] 1 [/SUP]
Affiliations
- PMID: 35578696
- PMCID: PMC9095075
- DOI: 10.1016/j.bsheal.2022.04.006
Abstract
At present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, which has emerged multiple variants and brought a global threat to public health. To analyze the genomic characteristics and variations of SARS-CoV-2 imported in Beijing, we collected the respiratory tract specimens of 112 cases of coronavirus disease 2019 (COVID-19) from January to September 2021 in Beijing, including 40 local cases and 72 imported cases. The whole-genome sequences of the viruses were sequenced by the next-generation sequencing method. Variant markers and phylogenic features of SARS-CoV-2 were analyzed. Our results showed that in all 112 sequences, the mutations were concentrated in spike protein. D614G was found in all sequences, and mutations including L452R, T478K, P681R/H, and D950N in some cases. Furthermore, 112 sequences belonged to 23 lineages by phylogenetic analysis. B.1.1.7 (Alpha) and B.1.617.2 (Delta) lineages were dominant. Our study drew a variation image of SARS-CoV-2 and could help evaluate the potential risk of COVID-19 for pandemic preparedness and response.
Keywords: Genome; Phylogenetic analysis; Severe acute respiratory syndrome coronavirus 2; Variation.