tetano
Editor, Senior Moderator
Biomedicines
. 2022 Jun 28;10(7):1526.
doi: 10.3390/biomedicines10071526.
Assessment of the Humoral Immune Response Following COVID-19 Vaccination in Healthcare Workers: A One Year Longitudinal Study
Mihaela Chivu-Economescu[SUP] 1 [/SUP], Teodora Vremera[SUP] 2 3 [/SUP], Simona Maria Ruta[SUP] 4 [/SUP], Camelia Grancea[SUP] 1 [/SUP], Mihaela Leustean[SUP] 2 [/SUP], Daniela Chiriac[SUP] 1 [/SUP], Adina David[SUP] 2 [/SUP], Lilia Matei[SUP] 1 [/SUP], Carmen C Diaconu[SUP] 1 [/SUP], Adina Gatea[SUP] 2 [/SUP], Ciprian Ilie[SUP] 2 [/SUP], Iuliana Radu[SUP] 2 [/SUP], Ana Maria Cornienco[SUP] 2 [/SUP], Luminita Smaranda Iancu[SUP] 5 6 [/SUP], Catalin Cirstoiu[SUP] 4 7 [/SUP], Corina Silvia Pop[SUP] 4 7 [/SUP], Radu Petru[SUP] 4 8 [/SUP], Victor Strambu[SUP] 4 8 [/SUP], Stefan Malciolu[SUP] 9 [/SUP], Corneliu Petru Popescu[SUP] 4 9 [/SUP], Simin Aysel Florescu[SUP] 4 9 [/SUP], Alexandru Rafila[SUP] 4 10 [/SUP], Florentina Ligia Furtunescu[SUP] 4 [/SUP], Adriana Pistol[SUP] 4 [/SUP]
Affiliations
Abstract
The continuous variability of SARS-CoV-2 and the rapid waning of specific antibodies threatens the efficacy of COVID-19 vaccines. We aimed to evaluate antibody kinetics one year after SARS-CoV-2 vaccination with an mRNA vaccine in healthcare workers (HCW), with or without a booster. A marked decline in anti-Spike(S)/Receptor Binding Domain (RBD) antibody levels was registered during the first eight months post-vaccination, followed by a transitory increase after the booster. At three months post-booster an increased antibody level was maintained only in HCW vaccinated after a prior infection, who also developed a higher and long-lasting level of anti-S IgA antibodies. Still, IgG anti-nucleocapsid (NCP) fades five months post-SARS-CoV-2 infection. Despite the decline in antibodies one-year post-vaccination, 68.2% of HCW preserved the neutralization capacity against the ancestral variant, with a decrease of only 17.08% in the neutralizing capacity against the Omicron variant. Nevertheless, breakthrough infections were present in 6.65% of all participants, without any correlation with the previous level of anti-S/RBD IgG. Protection against the ancestral and Omicron variants is maintained at least three months after a booster in HCW, possibly reflecting a continuous antigenic stimulation in the professional setting.
Keywords: SARS-CoV-2; booster dose; breakthrough infections; healthcare workers; host factors; immune response; vaccination.
. 2022 Jun 28;10(7):1526.
doi: 10.3390/biomedicines10071526.
Assessment of the Humoral Immune Response Following COVID-19 Vaccination in Healthcare Workers: A One Year Longitudinal Study
Mihaela Chivu-Economescu[SUP] 1 [/SUP], Teodora Vremera[SUP] 2 3 [/SUP], Simona Maria Ruta[SUP] 4 [/SUP], Camelia Grancea[SUP] 1 [/SUP], Mihaela Leustean[SUP] 2 [/SUP], Daniela Chiriac[SUP] 1 [/SUP], Adina David[SUP] 2 [/SUP], Lilia Matei[SUP] 1 [/SUP], Carmen C Diaconu[SUP] 1 [/SUP], Adina Gatea[SUP] 2 [/SUP], Ciprian Ilie[SUP] 2 [/SUP], Iuliana Radu[SUP] 2 [/SUP], Ana Maria Cornienco[SUP] 2 [/SUP], Luminita Smaranda Iancu[SUP] 5 6 [/SUP], Catalin Cirstoiu[SUP] 4 7 [/SUP], Corina Silvia Pop[SUP] 4 7 [/SUP], Radu Petru[SUP] 4 8 [/SUP], Victor Strambu[SUP] 4 8 [/SUP], Stefan Malciolu[SUP] 9 [/SUP], Corneliu Petru Popescu[SUP] 4 9 [/SUP], Simin Aysel Florescu[SUP] 4 9 [/SUP], Alexandru Rafila[SUP] 4 10 [/SUP], Florentina Ligia Furtunescu[SUP] 4 [/SUP], Adriana Pistol[SUP] 4 [/SUP]
Affiliations
- PMID: 35884831
- DOI: 10.3390/biomedicines10071526
Abstract
The continuous variability of SARS-CoV-2 and the rapid waning of specific antibodies threatens the efficacy of COVID-19 vaccines. We aimed to evaluate antibody kinetics one year after SARS-CoV-2 vaccination with an mRNA vaccine in healthcare workers (HCW), with or without a booster. A marked decline in anti-Spike(S)/Receptor Binding Domain (RBD) antibody levels was registered during the first eight months post-vaccination, followed by a transitory increase after the booster. At three months post-booster an increased antibody level was maintained only in HCW vaccinated after a prior infection, who also developed a higher and long-lasting level of anti-S IgA antibodies. Still, IgG anti-nucleocapsid (NCP) fades five months post-SARS-CoV-2 infection. Despite the decline in antibodies one-year post-vaccination, 68.2% of HCW preserved the neutralization capacity against the ancestral variant, with a decrease of only 17.08% in the neutralizing capacity against the Omicron variant. Nevertheless, breakthrough infections were present in 6.65% of all participants, without any correlation with the previous level of anti-S/RBD IgG. Protection against the ancestral and Omicron variants is maintained at least three months after a booster in HCW, possibly reflecting a continuous antigenic stimulation in the professional setting.
Keywords: SARS-CoV-2; booster dose; breakthrough infections; healthcare workers; host factors; immune response; vaccination.