tetano
Editor, Senior Moderator
Biomed Res Int
. 2020 May 30;2020:4389089.
doi: 10.1155/2020/4389089. eCollection 2020.
Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
Martina Bianchi[SUP] 1 [/SUP], Domenico Benvenuto[SUP] 2 [/SUP], Marta Giovanetti[SUP] 3 [/SUP], Silvia Angeletti[SUP] 4 [/SUP], Massimo Ciccozzi[SUP] 2 [/SUP], Stefano Pascarella[SUP] 1 [/SUP]
AffiliationsExpand
Abstract
The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.
. 2020 May 30;2020:4389089.
doi: 10.1155/2020/4389089. eCollection 2020.
Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
Martina Bianchi[SUP] 1 [/SUP], Domenico Benvenuto[SUP] 2 [/SUP], Marta Giovanetti[SUP] 3 [/SUP], Silvia Angeletti[SUP] 4 [/SUP], Massimo Ciccozzi[SUP] 2 [/SUP], Stefano Pascarella[SUP] 1 [/SUP]
AffiliationsExpand
- PMID: 32596311
- PMCID: PMC7261327
- DOI: 10.1155/2020/4389089
Abstract
The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.